Human T-cell-porcine endothelial cell interactions induce human Th1 cytokines and porcine activation markers

Journal of Surgical Research

Volumn 97, Issue 2, 2001, Pages 184-191

  Coleman, T S ^a   Pittman, H K ^a   Purser, S M ^a   Haisch, C E ^a   Verbanac, K M ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Cell adhesion molecules; Cytokines; Endothelial cells; IFN ; MHC; Mixed lymphocyte endothelial cell culture; TNF ; VCAM; Xenogeneic responses; Xenotransplantation

Indexed keywords

CYTOKINE; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; AORTA; ARTICLE; CELL INTERACTION; CELL PROLIFERATION; CELL SURFACE; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SWINE; T LYMPHOCYTE; XENOGRAFT; XENOTRANSPLANTATION;

EID: 0035746864     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.2001.6151     Document Type: Article

References (23)

1. Xenotransplantation
2. New directions for organ transplantation
3. Xenotransplantation: Immune barriers beyond hyperacute rejection
4. Barriers to xeno-transplantation
5. Alloantigenicity of human endothelial cells. 1. Frequency and phenotype of human T helper lymphocytes that can react to allogeneic endo-thelial cells
6. Functional interaction of T cells with endothelial cells: The role of CD40L-CD40-mediated signals
7. A comparison of primary endothelial cells and endothelial cell lines for studies of immune interactions
8. Evidence that activation of human T cells by porcine endothelium involves direct recognition of porcine SLA and costimulation by porcine ligands for LFA-1 and CD2
9. Direct recognition of SLA- and HLA-like class II antigens on porcine endothelium by human T cells results in T cell activation and release of interleukin- 2
10. Human anti-porcine xenogeneic T cell response: Evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition
11. Indirect recognition of porcine xenoantigens by human CD4+ T cell clones
12. Recognition of porcine major histocompatibility complex class I antigens by human CD8+ cytolytic T cell clones
13. Human-porcine receptor-ligand compatibility within the immune system: Relevance for xenotransplantation
14. Effect of human cytokines (IFN-γ, TNF-α, IL-1β, IL-4) on porcine endothelial cells: Induction of MHC and adhesion molecules and functional significance of these changes
15. TNF-α, IL-4, and IFN-γ regulate differential expression of P- and E-selectin expression by porcine aortic endothelial cells
16. Novel responses by transgenic pig endothelial cells to stimulation by human cytokines in terms of H-DAF, E-selectin and major histocompatibility complex class II expression
17. Effect of human inflammatory cytokines on porcine endothelial cell MHC molecule expression: Unique role for TNF-α in MHC class-II induction
18. Interleukin-1 increases the production of endothelin-1 by cultured endothelial cells
19. Regulation of monocyte tissue factor activity by allogeneic and xenogeneic endothelial cells
20. Effect of a platelet-activating factor (PAF) receptor antagonist on hyper-acute xenograft rejection; evaluation in a pig kidney-human blood xenoperfusion model
21. Endothelial cell activation by pore-forming structures: Pivotal role for interleukin-1 alpha
22. Pig but not human interferon-γ initiates human cell-mediated rejection of pig tissue in vivo