The tumor cells in nodular lymphocyte-predominant Hodgkin disease are clonally related to the large cell lymphoma occurring in the same individual: Direct demostration by single cell analysis

American Journal of Clinical Pathology

Volumn 116, Issue 4, 2001, Pages 506-511

  Ohno, Toshiyuki ^a   Huang, James Z ^a   Wu, Grant ^a   Park, Kwang Hwa ^a   Weisenburger, Dennis D ^a   Chan, Wing C ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Complementarity determining region; Immunoglobulin heavy chain gene; Large cell lymphoma; Lymphocytic and histiocytic; Micromanipulation; Nodular lymphocyte predominant Hodgkin disease; Polymerase chain reaction; Sequence analysis; Single cell analysis

Indexed keywords

BLEOMYCIN; CHLORMETHINE; DACARBAZINE; DOXORUBICIN; IMMUNOGLOBULIN HEAVY CHAIN; PREDNISONE; PROCARBAZINE; VINCRISTINE;

ADULT; ANALYTIC METHOD; ARTICLE; CASE REPORT; CELL ISOLATION; CHROMOSOME MICRODISSECTION; COMPLEMENTARITY DETERMINING REGION; DISEASE ASSOCIATION; GENE AMPLIFICATION; GERMINAL CENTER; HISTIOCYTOSIS; HODGKIN DISEASE; HUMAN; IMMUNOHISTOCHEMISTRY; LARGE CELL LYMPHOMA; LYMPHOCYTE CLONE; MALE; MICROMANIPULATION; NODULAR LYMPHOMATOSIS; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REED STERNBERG CELL; SEQUENCE ANALYSIS; SINGLE CELL ANALYSIS; TISSUE SECTION;

EID: 0035736317     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/KY8C-LCYN-QHJ6-4C6R     Document Type: Article

References (24)

1. The pathology and nomenclature of Hodgkin's disease
2. Nodular and diffuse types of lymphocyte predominance Hodgkin's disease
3. A comparative study of the nodular and diffuse variants of lymphocyte-predominant Hodgkin's disease
4. Cellular origin of nodular lymphocytic predominance Hodgkin's lymphoma: Immunophenotypic and molecular studies
5. The diversity of the immunohistological staining pattern of Sternberg-Reed cells
6. Reed-Sternberg and Hodgkin cells in lymphocyte-predominant Hodgkin's disease of nodular subtype contain J chain
7. The immunohistology of Hodgkin's disease: Reed-Sternberg cells and their variants
8. Hodgkin's disease, lymphocyte predominance type, nodular: Further evidence for a B cell derivation: L&H variants of Reed-Sternberg cells express L26, a pan B cell marker
9. Expression of the Ig-associated heterodimer (mb-1 and B29) in Hodgkin's disease
10. Hodgkin's disease, lymphocytic predominance nodular: Increased risk for subsequent non-Hodgkin's lymphomas
11. Lymphocyte predominant Hodgkin's disease nodular subtype with coexistent "large cell lymphoma": Histological progression or composite malignancy?
12. Nodular paragranuloma can transform into high-grade malignant lymphoma of B type
13. Further phenotypic evidence that nodular, lymphocyte-predominant Hodgkin's disease is a large B-cell lymphoma in evolution
14. Simultaneous lymphocyte predominant Hodgkin's disease and large-cell lymphoma
15. Clonal relationship between lymphocytic predominance Hodgkin's disease and concurrent or subsequent large-cell lymphoma of B lineage
16. Nodular lymphocyte-predominant Hodgkin's disease associated with large-cell lymphoma: Analysis of Ig gene rearrangements by V-J polymerase chain reaction
17. Molecular studies on single cells harvested by micromanipulation from archival tissue sections previously stained by immunohistochemistry or nonisotopic in situ hybridization
18. Clonality in nodular lymphocyte-predominant Hodgkin's disease
19. Obtaining clone-specific primer and probe for the immunoglobulin heavy-chain gene from paraffin-embedded tissue of B-cell lymphoma: Technical considerations
20. Clonal identification of Burkitt's lymphoma arising from lymphocyte-predominant Hodgkin's disease
21. Combination of Hodgkin's disease and diffuse large cell lymphoma: An in situ hybridization study for immunoglobulin light chain messenger RNA
22. Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells
23. Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells
24. Diffuse large B-cell lymphoma (DLBCL) arising in lymphocyte predominance Hodgkin's disease (LPHD)