Prediction models for eye irritation potential based on endpoints of the HETCAM and neutral red uptake tests

In Vitro and Molecular Toxicology: Journal of Basic and Applied Research

Volumn 14, Issue 3, 2001, Pages 143-156

  Worth, Andrew P ^a   Cronin, Mark T D ^a  

^a JOINT RESEARCH CENTRE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHORIOALLANTOIS; EUROPEAN UNION; EYE IRRITATION; GERMANY; HEN; LOGISTIC REGRESSION ANALYSIS; PREDICTION; RABBIT; REGULATORY MECHANISM; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL; STATISTICS; VALIDATION PROCESS;

ORYCTOLAGUS CUNICULUS;

EID: 0035733789     PISSN: 10979336     EISSN: None     Source Type: Journal    
DOI: 10.1089/109793301753407911     Document Type: Article

References (11)

1. Eye irritation testing: The way forward. The report and recommendations of ECVAM workshop 34
2. Describing the validity of carcinogen screening tests
3. Methods for study of irritation and toxicity of substances applied topically to the skin and mucous membranes
4. Commission Directive 93/21/EEC of 27 April 1993 adapting to technical progress for the 18th time Council Directive 67/548/EEC on the approximation of laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances
5. Validation study of alternatives to the Draize eye irritation test in Germany: Cytotoxicity testing and HET-CAM test with 136 industrial chemicals
6. Results of a validation study in Germany on two in vitro alternatives to the Draize eye irritation test, the HET-CAM test and the 3T3-NRU cytotoxicity test
7. The importance of the prediction model in the validation of alternative tests