The proportion of Th1 cells, which prevail in gut mucosa, is decreased in inflammatory bowel syndrome

Clinical and Experimental Immunology

Volumn 125, Issue 3, 2001, Pages 383-390

  Van Damme, N ^a   De Keyser, F ^a   Demetter, P ^a   Baeten, D ^a   Mielants, H ^a   Verbruggen, G ^a   Cuvelier, C ^a   Veys, E M ^a   De Vos, M ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Crohn's disease; Mucosal lymphocytes; Th1; Th2; Ulcerative colitis

Indexed keywords

CD3 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; IONOMYCIN;

ADOLESCENT; ADULT; AGED; ARTICLE; BIOPSY; CLINICAL ARTICLE; COLON BIOPSY; CONTROLLED STUDY; CROHN DISEASE; ENTERITIS; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; ILEUM; IMMUNE RESPONSE; INTESTINE MUCOSA; LAMINA PROPRIA; MALE; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ADOLESCENT; ADULT; CELLS, CULTURED; COLITIS, ULCERATIVE; CROHN DISEASE; CYTOKINES; FEMALE; HUMANS; INFLAMMATORY BOWEL DISEASES; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-4; INTESTINAL MUCOSA; MALE; MIDDLE AGED; SYNDROME; TH1 CELLS;

EID: 0035717011     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2001.01638.x     Document Type: Article

References (41)

1. Immunology of ulcerative colitis and Crohn's disease
2. Immunology of inflammatory bowel disease: Summary of the proceedings of the subcommittee on immunosuppressive use in IBD
3. The expanding universe of T-cell subsets: Th1, Th2 and more
4. Cytokines in inflammatory bowel disease
5. Interferon-γ receptor-deficient mice exhibit impaired gut mucosal immune responses but intact oral tolerance
6. The interleukin-2 T-cell system: A new cell growth model
7. Human T-lymphocyte growth factor: Regulation of growth and function of T lymphocytes
8. Homeostasis and self-tolerance in the immune system: Turning lymphocytes off
9. Interleukin-4: A prototypic immunoregulatory lymphokine
10. Lymphocyte response and cytokines
11. 2
12. Coordinated antiinflammatory effect of interleukin 4: Interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist
13. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
14. IL-10 is produced by subsets of human CD4+ T cell clones and perpheral blood T cells
15. Epstein-Barr virus transformation induces B lymphocytes to produce human interleukin 10
16. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells
17. Interleukin 10 inhibits allogeneic proliferative and cytotoxic responses generated in primary mixed lymphocyte cultures
18. Flow cytometric analysis of gut mucosal lymphocytes supports an impaired Th1 cytokine profile in spondyloarthropathy
19. Flow cytometric single-cell analysis of cytokine production by CD4+ T cells in synovial tissue and peripheral blood from patients with rheumatoid arthritis
20. Regulation of CD4 and CD8 expression on mouse T cells. Active removal from the surface by two mechanisms
21. Assessment of cytokines by immunofluorescence and the paraformaldehyde-saponin procedure
22. Detection of intracellular cytokines by flow cytometry
23. Decreased frequency of interferon-γ and interleukin-2 producing cells in patients with atopic diseases measured at the single cell level
24. Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies
25. Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis
26. Interleukin-2- and interferon-γ-secreting cells in normal and diseased human intestinal mucosa
27. Spontaneous release of interferon γ by intestinal lamina propria lymphocytes in Crohn's disease. Kinetics of in vitro response to interferon γ inducers
28. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease
29. Interferon γ production by human intestinal mucosal mononuclear cells: Decreased levels in inflammatory bowel disease
30. Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine
31. Expression of HLA-DR antigens in inflammatory bowel disease mucosa: Role of intestinal lamina propria mononuclear cell-derived interferon-γ
32. Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease
33. Increased concentrations of interleukin 1β, interleukin-2, and soluble interleukin-2 receptors in endoscopical mucosal biopsy specimens with active inflammatory bowel disease
34. Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR)
35. Loss of interleukin-2-producing intestinal CD4+ T cells in inflammatory bowel disease
36. Interleukin 2 activity of human intestinal mucosa mononuclear cells. Decreased levels in inflammatory bowel disease
37. Azathioprine mycophenolate mofetil and methotrexate specifically modulate cytokine production by T cells
38. The evolution of spondyloarthropathies in relation to gut histology. III. Relation between gut and joint
39. Long-term evolution of gut inflammation in patients with spondyloarthropathy
40. A role for TNF-α and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease
41. Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis