Isoniazid is a mechanism-based inhibitor of cytochrome P450 1A2, 2A6, 2C19 and 3A4 isoforms in human liver microsomes

European Journal of Clinical Pharmacology

Volumn 57, Issue 11, 2002, Pages 799-804

  Wen, Xia ^a   Wang, Jun Sheng ^a   Neuvonen, Pertti J ^a   Backman, Janne T ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Cytochrome P450; Inhibition; Interaction; Isoniazid

Indexed keywords

CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; ISOENZYME; ISONIAZID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG SPECIFICITY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TIME; LIVER MICROSOME; MALE; PRIORITY JOURNAL;

ANTITUBERCULAR AGENTS; ARYL HYDROCARBON HYDROXYLASES; BIOLOGICAL MARKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; HUMANS; ISOENZYMES; ISONIAZID; KINETICS; MALE; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; NADP;

EID: 0035712266     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-001-0396-3     Document Type: Article

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