Mutation of the immunodominant CD8+ epitope in the MHV-4 spike protein

Advances in Experimental Medicine and Biology

Volumn 494, Issue , 2001, Pages 121-125

  Ming, Ming Chua ^a   Phillips, Joanna J ^a   Seo, Su Hun ^a   Lavi, Ehud ^a   Weiss, Susan R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; EPITOPE; SPIKE PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CELLULAR IMMUNITY; CENTRAL NERVOUS SYSTEM INFECTION; CONFERENCE PAPER; CONTROLLED STUDY; DEMYELINATION; LD 50; MOUSE; MURINE HEPATITIS CORONAVIRUS; NONHUMAN; PARALYSIS; PRIORITY JOURNAL; STRAIN DIFFERENCE; T LYMPHOCYTE; VIRUS ENCEPHALITIS; VIRUS PATHOGENESIS; VIRUS STRAIN;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CORONAVIRUS INFECTIONS; ENCEPHALOMYELITIS; EPITOPES, T-LYMPHOCYTE; IMMUNODOMINANT EPITOPES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MURINE HEPATITIS VIRUS; MUTATION; RECOMBINATION, GENETIC; VIRAL ENVELOPE PROTEINS;

ANIMALIA; CORONAVIRUS; MURINAE; MURINE HEPATITIS VIRUS; MURINE HEPATITIS VIRUS STRAIN 4;

EID: 0035704306     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (7)

1. Predominance of MHC class II restricted CD4+ T cells against mouse hepatitis virus A59
2. Retargeting of coronavirus by substitution of the spike glycoprotein ectodomain: Crossing the host cell species barrier
3. Altered pathogenesis of a mutant of the murine coronavirus MHV-A59 is associated with a Q159L amino acid substitution in the spike protein
4. Pathogenesis of coronavirus-induced infections. Review of pathological and immunological aspects
5. Cytotoxic T cell-resistant variants are selected in a virus-induced demyelinating disease
6. Pathogenesis of chimeric MHV-4/MHV-A59 recombinant viruses: The murine coronavirus spike protein is a major determinant of neurovirulence