In-situ hybridization studies of protein kinase C α and β I isoforms in human diabetic nephropathy

Clinical and Experimental Nephrology

Volumn 5, Issue 4, 2001, Pages 250-256

  Toyoda, M ^a   Suzuki, D ^a   Zhang, S ^a   Umezono, T ^a   Sakai, H ^a  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Diabetic nephropathy (DN); In situ hybridization; Protein kinase C (PKC) ; Protein kinase C (PKC) I

Indexed keywords

DIGOXIGENIN; MESSENGER RNA; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA;

ADULT; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; DIABETIC NEPHROPATHY; ENZYME ACTIVATION; ENZYME ANALYSIS; FEMALE; HUMAN; HUMAN CELL; HYPERGLYCEMIA; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0035702791     PISSN: 13421751     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10157-001-8022-3     Document Type: Article

References (34)

1. Preferential elevation of protein kinase C isoform β II and diacylglycerol levels in the aorta and heart of diabetic rats: Differential reversibility to glycemic control by islet cell transplantation
2. Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation
3. Characterization of protein kinase C β isoform activation on the gene expression of transforming growth factor-β, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats
4. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC β inhibitor
5. Protein kinase C is activated in glomeruli from streptozotocin diabetic rats: Possible mediation by glucose
6. Increase in diacylglycerol mass in isolated glomeruli by glucose from de novo synthesis of glycerolipids
7. Prevention of albuminuria by aminoguanidine or ramipril in streptozotocin-induced diabetic rats is associated with the normalization of glomerular protein kinase C
8. D-α-Tocopherol treatment prevents glomerular dysfunctions in diabetic rats through inhibition of protein kinase C-diacylglycerol pathway
9. Mitogen-activated protein kinase cascade is activated in glomeruli of diabetic rats and glomerular mesangial cells cultured under high glucose conditions
10. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
11. The MAPK signaling cascade
12. The regulation of AP-1 activity by mitogen-activated protein kinases
13. Translocation of protein kinase C α and ζ in rat glomerular mesangial cells cultured under high glucose conditions
14. Modified open renal biopsy: Results in 934 patients
15. In situ hybridization of interleukin 6 in diabetic nephropathy
16. In situ hybridization studies of matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-1 and type IV collagen in diabetic nephropathy
17. The role of protein kinase C in cell surface signal transduction and tumor promotion
18. Studies and perspective of protein kinase C
19. Increased endothelial albumin permeability mediated by protein kinase C activation
20. TPA-induced contraction of isolated rabbit vascular smooth muscle
21. Possible involvement of protein kinase C in platelet-derived growth factorstimulated DNA synthesis in vascular smooth muscle cells
22. Structure of the human type IV collagenase gene
23. Regulation of insulin receptor internalization in vascular endothelial cells by insulin and phorbol ester
24. The mitogenic signaling pathway but not plasminogen activator inducing pathway of basic fibroblast growth factor is mediated through protein kinase C in fetal bovine aortic endothelial cells
25. Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus
26. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
27. Protein kinase C and lipid signaling for sustained cellular responses
28. Protein kinase C activation and the development of diabetic complications
29. Altered expression and subcellular localization of diacylglycerol-sensitive protein kinase C isoforms in diabetic rat glomerular cells
30. Differential expression of protein kinase C isoforms in streptozotocin-induced diabetic rats
31. Expression of protein kinase C isoforms in renal tissue
32. Immunocharacterization of protein kinase C isoenzymes in rat kidney glomeruli, and cultured glomerular epithelial and mesangial cells
33. Immunolocalization of protein kinase C isozymes α, β I and β II in rat kidney
34. Acute hyperglycemia regulates transcription and posttranscriptional stability of PKC β II mRNA in vascular smooth muscle cells