Lack of binding to isolated estrogen or androgen receptors, and inactivity in the immature rat uterotrophic assay, of the ultraviolet sunscreen filters Tinosorb M-active and Tinosorb S

Regulatory Toxicology and Pharmacology

Volumn 34, Issue 3, 2001, Pages 287-291

  Ashby, J ^a   Tinwell, H ^a   Plautz, J ^b   Twomey, K ^a   Lefevre, P A ^a  

^a JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

^b CIBA GEIGY LTD   (Switzerland)

Author keywords

Endocrine disruption; Estrogen androgen receptor binding; Sunscreens; Uterotrophic assay

Indexed keywords

ANDROGEN RECEPTOR; ESTRADIOL; ESTROGEN RECEPTOR; FULVESTRANT; METRIBOLONE; SUNSCREEN; TESTOSTERONE; TINOSORB M ACTIVE; TINOSORB S; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; BIOASSAY; CONTROLLED STUDY; DOSE RESPONSE; DRUG RECEPTOR BINDING; ESTROGEN ACTIVITY; FEMALE; MOLECULAR SIZE; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING; UTEROTROPHIC ASSAY;

EID: 0035702141     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.2001.1511     Document Type: Article

References (13)

1. Uterotrophic activity of bisphenol A in the immature rat
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4. Re-evaluation of the first synthetic estrogen, 1-keto-1,2,3,4-tetrahydrophenanthrene, and bisphenol A, using both the ovariectomised rat model used in 1933 and additional assays
5. Replacement of surgical castration by GnRH inhibition for rat prostate androgen receptor preparations
6. Antarelix (EP 24332) a novel water soluble LHRH antagonist
7. Structure-activity relationships for a large diverse set of natural, synthetic, and environmental estrogens
8. Receptor binding as a tool in the development of new bioactive steroids
9. In vitro and in vivo estrogenicity of UV screens
10. Assessing environmental chemicals for estrogenicity using a combination of in vivo and in vitro assays
11. QSAR models using a large diverse set of estrogens