NK30424A and B, novel inhibitors of lipopolysaccharide-induced tumour necrosis factor alpha production, produced by Streptomyces sp. NA30424

Journal of Antibiotics

Volumn 54, Issue 12, 2001, Pages 1111-1115

  Takayasu, Yoshiyuki ^a   Tsuchiya, Kouichi ^a   Aoyama, Takayuki ^a   Sukenaga, Yoshikazu ^a  

^a NIPPON KAYAKU CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; BACTERIUM LIPOPOLYSACCHARIDE; BETA GALACTOSIDASE; GLUTARIMIDE DERIVATIVE; I KAPPA B ALPHA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; NEOMYCIN; NK 30424A; NK 30424B; PROTEIN INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY TEST; DRUG CONFORMATION; DRUG EFFECT; DRUG ISOLATION; DRUG SYNTHESIS; FERMENTATION; LETTER; MALE; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PERITONEAL EXUDATE CELL; PERITONITIS; PRIORITY JOURNAL; PROMOTER REGION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; STEREOISOMERISM; STREPTOMYCES; STRUCTURE ACTIVITY RELATION; TARGET CELL DESTRUCTION;

STREPTOMYCES;

EID: 0035700576     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.54.1111     Document Type: Letter

References (5)

1. Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-κB proteins in human monocytic THP-1
2. How NF-κB is activated: The role of the IκB kinase (IKK) complex
3. Aberrant rel/nfkb genes and activity in human cancer
4. Induction of tumour necrosis factor, IFN-γ an acute lethality in mice by toxic and non-toxic forms of lipid A
5. κB-Type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumour necrosis factor-α gene in primary macrophages