NAD(P)H:quinone oxidoreductase (NQO1) protects astroglial cells against L-Dopa toxicity

Advances in Experimental Medicine and Biology

Volumn 500, Issue , 2001, Pages 237-240

  Drukarch, Benjamin ^a   Jongenelen, Cornelis A M ^a   Van Muiswinkel, Freek L ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROPTERIDINE REDUCTASE; LEVODOPA; OXIDOREDUCTASE; QUINONE OXIDOREDUCTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ASTROCYTE; CATALYSIS; CELL GROWTH; CELL SURVIVAL; CHEMICAL REACTION; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; LONG TERM EXPOSURE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; REACTION ANALYSIS; SCAVENGING SYSTEM;

ANIMALIA;

EID: 0035699906     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-0667-6_35     Document Type: Conference Paper

References (11)

1. Levodopa, is toxicity a myth?
2. Biochemical and toxicological properties of the oxidation products of catecholamines
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4. Molecular characterization of binding of substrates and inhibitors to DT-diaphorase: Combined approach involving site-directed mutagenesis, inhibitor-binding analysis, and computer modeling
5. Drug treatment of Parkinson's disease: Time for phase II
6. Astrocyte enhanced neuronal survival is mediated by scavenging of extracellular reactive oxygen species
7. L-Dopa up-regulates glutathione and protects mesencephalic cultures against oxidative stress
8. Histochemical detection of quinone reductase activity in situ using LY 83583 reduction and oxidation
9. Distribution of DT diaphorase in the rat brain: Biochemical and immunohistochemical studies
10. Chronic dopamine D2 receptor activation does not affect survival and differentiation of cultured dopaminergic neurons: Morphological and neurochemical observations
11. L-Dopa stimulates expression of the anti-oxidant enzyme NAD(P)H:quinone oxidoreductase (NQO) in cultured astroglial cells