A topical nitric oxide-generating therapy for cutaneous leishmaniasis

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 94, Issue 3, 2000, Pages 319-322

  Davidson, Robert N ^a   Yardley, Vanessa ^b   Croft, Simon L ^b   Konecny, Pamela ^a   Benjamin, Nigel ^c  

^a NORTHWICK PARK HOSPITAL   (United Kingdom)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

Cutaneous leishmaniasis; Experimental model; Leishmania major; Leishmania tropica; Nitric oxide generating creams; Syria; Topical chemotherapy

Indexed keywords

ASCORBIC ACID; NITRIC OXIDE; NITRITE; SALICYLIC ACID;

ACIDIFICATION; ADOLESCENT; ADULT; AGED; AMASTIGOTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MALE; NONHUMAN; PROMASTIGOTE; SKIN LEISHMANIASIS; SYRIAN ARAB REPUBLIC;

ANIMALIA; LEISHMANIA MAJOR; LEISHMANIA TROPICA; PROTOZOA;

EID: 0034084218     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0035-9203(00)90341-9     Document Type: Article

References (13)

1. Ashford, R. W., Rioux, J.-A., Jalouk, L., Khiami, A. & Dye, C. (1993). Evidence for a long-term increase in the incidence of Leishmania tropica in Aleppo, Syria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 87, 247-249.
2. Bogdan, C., Gessner, A., Solbach, A. & Rollinghoff, M. (1996). Invasion, control, and persistence of Leishmania parasites. Current Opinon in Immunology, 8, 517-525.
3. Bryceson, A. D. M. (1996). Leishmaniasis. In: Manson's Tropical Diseases, 20th edition, Cook, G. C. (editor). London: WB Saunders Ltd, pp. 1213-1245.
4. Desjeux, P. (1996). Leishmaniasis: public health aspects and control. Clinical Dermatology, 14, 417-423.
5. Diefenbach, A., Schindler, H., Rollinghoff, M., Yokoyama, W. M. & Bogdan, C. (1999). Requirement for type 2 NO synthase for IL-12 signaling in innate immunity. Science, 284, 951-955.
6. Douba, M., Mowakeh, A. & Wali, A. (1997). Current status of cutaneous leishmaniasis in Aleppo, Syrian Arab Republic. Bulletin of the World Health Organization, 75, 253-259.
7. Dykhuizen, R. S., Frazer, R., Duncan, C., Smith, C. C., Golden, M., Benjamin, N. & Leifert, C. (1996). Antimicrobial effect of acidified nitrite on gut pathogens: importance of dietary nitrate in host defense. Antimicrobial Agents and Chemotherapy, 40, 1422-1425.
8. El On, J., Halevy, S., Grunwald, M. H. & Weinrauch, L. (1992). Topical treatment of Old World cutaneous leishmaniasis caused by Leishmania major: a double-blind control study. Journal of the American Academy of Dermatology, 27, 227-231.
9. Fang, F. C. (1997). Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity. Journal of Clinical Investigation, 99, 2818-2825.
10. Lopez-Jaramillo, P., Ruano, C., Rivera, J., Teran, E., Salazar Irigoyen, R., Esplugues, J. V. & Moncada, S. (1998). Treatment of cutaneous leishmaniasis with nitric-oxide donor. Lancet, 351, 1176-1177.
11. Proudfoot, L., O'Donnell, C. A. & Liew, F. Y. (1995). Glycoinositolphospholipids of Leishmania major inhibit nitric oxide synthesis and reduce leishmanicidal activity in murine macrophages. European Journal of Immunology, 25, 745-750.
12. Reece, W. H. H., Proudfoot, L., Coombs, G. H. & Liew, F. Y. (1996). Quantification and characterisation of the effect of reactive nitrogen intermediates on Leishmania mexicana. In: The Biology of Nitric Oxide Part 5, Moncada, S., Stamler, J., Gross, S. & Higgs, E. A. (editors). London: Portland Press, p. 169.
13. Soto, J., Hernandez, N., Mejia, H., Grogl, M. & Berman, J. (1995). Successful treatment of New World cutaneous leishmaniasis with a combination of topical paromomycin/ methylbenzethonium chloride and injectable meglumine antimonate. Clinical Infectious Diseases, 20, 47-51.