Mapping of natural anti-factor VIII antibodies in plasma pools from healthy donors: Use of rationally designed synthetic peptides

Biologicals

Volumn 29, Issue 3-4, 2001, Pages 229-232

  Di Giambattista, Mario ^a   Branckaert, Theo ^a   Laub, Ruth ^a  

^a Rode Kruis Vlaanderen   (Belgium)

Author keywords

Auto antibodies; FVIII; Inhibitors; Synthetic peptides

Indexed keywords

BLOOD CLOTTING FACTOR 8 ANTIBODY; BLOOD CLOTTING FACTOR 8 ANTIBODY INHIBITOR; IMMUNOGLOBULIN G; IMMUNOGLOBULIN SUBCLASS; SEPHAROSE; SYNTHETIC PEPTIDE; THROMBIN; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ALGORITHM; ANTIBODY PRODUCTION; AUTOIMMUNE DISEASE; B LYMPHOCYTE; BLOOD CLOTTING; BLOOD CLOTTING FACTOR DEFICIENCY; BLOOD COMPONENT THERAPY; CELL PROLIFERATION; CHEMICAL STRUCTURE; COMPUTER PREDICTION; CONFERENCE PAPER; DOSE RESPONSE; DRUG DESIGN; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; GENE MAPPING; HEMOPHILIA; HEMOPHILIA A; HUMAN; HYPOTHESIS; IMMUNOGLOBULIN PRODUCTION; LYMPHOCYTE CLONE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN PURIFICATION; WESTERN BLOTTING;

EID: 0035697614     PISSN: 10451056     EISSN: None     Source Type: Journal    
DOI: 10.1006/biol.2001.0295     Document Type: Conference Paper

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7. Healthy subjects produce both anti-factor VIII and specific anti-idiotypic antibodies
8. Antibodies to the FVIII light chain that neutralize FVIII procoagulant activity are present in plasma of nonresponder patients with severe hemophilia A and in normal polyclonal human IgG
9. A detailed comparison of the performance of the standard versus the Nijmegen modification of the Bethesda assay in detection factor VIII:C inhibitors in the haemophilia A population of Canada
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13. An assessment of prediction methods for locating continuous epitopes in proteins
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15. Hemophilic factor VIII C1- and C2-domain missense mutations and their modelling to the 1.5-angstrom human C2-domain crystal structure