Effects of phenothiazine neuroleptics on the rate of caffeine demethylation and hydroxylation in the rat liver

Polish Journal of Pharmacology

Volumn 53, Issue 6, 2001, Pages 615-621

  Daniel, Wladyslawa A ^a   Syrek, Maciej ^a   Rylko, Zbigniew ^a   Kot, Marta ^a  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

Caffeine oxidation; Chlorpromazine; Cytochrome P 450 activity; Levomepromazine; Perazine; Rat; Thioridazine

Indexed keywords

CAFFEINE; CHLORPROMAZINE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2B; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; CYTOCHROME P450 3A2; CYTOCHROME P450 ISOENZYME; LEVOMEPROMAZINE; NEUROLEPTIC AGENT; PARAXANTHINE; PERAZINE; PHENOTHIAZINE DERIVATIVE; THEOBROMINE; THEOPHYLLINE; THIORIDAZINE; URIC ACID DERIVATIVE;

ANIMAL TISSUE; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DEMETHYLATION; DRUG METABOLISM; DRUG OXIDATION; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROXYLATION; LIVER MICROSOME; MALE; NONHUMAN; RAT;

ANIMALS; ANTIPSYCHOTIC AGENTS; ARYL HYDROCARBON HYDROXYLASES; CAFFEINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DEALKYLATION; HYDROXYLATION; ISOENZYMES; KINETICS; MALE; MICROSOMES, LIVER; OXIDOREDUCTASES, N-DEMETHYLATING; PHENOTHIAZINES; RATS; RATS, WISTAR; SUBSTRATE SPECIFICITY; THEOBROMINE; THEOPHYLLINE; URIC ACID;

EID: 0035695466     PISSN: 12306002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. On the serum concentrations and antipsychotic effects of thioridazine, thioridazine side-chain sulfoxide and thioridazine side-chain sulfone in chronic psychotic patients
2. Dextromethorphan and mephenytoin phenotyping of patients treated with thioridazine or amitriptyline
3. Caffeine increases its own metabolism through cytochrome P4501A induction in rats
4. Interspecies variations in caffeine metabolism related to cytochrome P4501A enzymes
5. Metabolism of thioridazine by microsomal monooxygenases: Relative roles of P-450 and flavin-containing monooxygenase
6. Accumulation and elimination of a novel metabolite during chronic administration of the phenothiazine drug perazine to rats
7. Prediction and evaluation criteria in perazine therapy of acute schizophrenics. Pharmaco-kinetic data
8. Stereo- and regioselective N- and S-oxidation of tertiary amines and sulfides in the presence of adult human liver microsomes
9. Involvement of CYP3A1, 2B1, and 2E1 in C-8 hydroxylation and CYP1A2 and flavin-containing monooxygenase in N-demethylation of caffeine; identified by using inducer treated rat liver microsomes that are metabolic patterns
10. Disposition of perphenazine is related to the polymorphic hydroxylation in human beings
11. Effects of selective cytochrome P-450 inhibitors on the metabolism of thioridazine
12. Pharmacokinetics and metabolism of thioridazine during co-administration of tricyclic antidepressants
13. Pharmacokinetics of thioridazine and its metabolites in blood plasma and the brain of rats after acute and chronic treatment
14. Effects of antidepressant drugs on the activity of cytochrome P-450 measured by caffeine oxidation in rat liver microsomes
15. Contribution of lysosomal trapping to the total tissue uptake of psychotropic drugs
16. i
17. Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae
18. Biotransformation of caffeine and teophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms
19. Quantitative assessment of caffeine partial clearances in man
20. Clinical implications of slow sulphoxidation of thioridazine in a poor metabolizer of the debrisoquine type
21. Determination of theophylline and its metabolites in human urine and plasma by high-performance liquid chromatography
22. Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP) isoforms in vitro: Preferential inhibition of CYP2D6
23. Cytochrome P-450 enzymes and FMO3 contribute to the disposition of the antipsychotic drug perazine in vitro
24. Caffeine metabolism by human hepatic cytochromes P450: Contributions of 1A2, 2E1 and 3A isoforms
25. Plasma levels of thioridazine and metabolites are influenced by the debrisoquine hydroxylation phenotype
26. Identification of human cytochrome P450 isoforms involved in the 7-hydroxylation of chlorpromazine by human liver microsomes