Increased expression of angiotensin-converting enzyme in retinas of diabetic rats

Japanese Journal of Ophthalmology

Volumn 45, Issue 6, 2001, Pages 585-591

  Okada, Yuji ^a,b   Yamanaka, Ichiro ^a   Sakamoto, Taiji ^a   Hata, Yasuaki ^a   Sassa, Yukio ^a   Yoshikawa, Hiroshi ^a   Fujisawa, Kimihiko ^a   Ishibashi, Tatsuro ^a   Inomata, Hajime ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b SANTEN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Angiotensin converting enzyme; Diabetic retinopathy; Renin angiotensin system; Retinal vessels; Streptozotocin

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; PHOSPHOTRANSFERASE; STREPTOZOCIN; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE COURSE; ENZYME LOCALIZATION; FROZEN SECTION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RETINA; RETINA BLOOD VESSEL; SIGNAL TRANSDUCTION;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; ENDOTHELIAL GROWTH FACTORS; IMMUNOENZYME TECHNIQUES; LYMPHOKINES; PEPTIDYL-DIPEPTIDASE A; RATS; RATS, WISTAR; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RENIN-ANGIOTENSIN SYSTEM; RETINAL VESSELS; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0035692498     PISSN: 00215155     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-5155(01)00412-9     Document Type: Article

References (28)

1. Local renin-angiotensin system: Especially in coagulating glands of mice
2. The renin-angiotensin system in the rabbit eye
3. The renin-angiotensin system in the human eye
4. Serum angiotensin-converting enzyme: Elevations in diabetes mellitus
5. Angiotensin I converting enzyme (kininase II) in isolated retinal microvessels
6. Angiotensin-converting enzyme activity in retinas of streptozotocin-induced and Zucker diabetic rats
7. Demonstration of renin mRNA, angiotensinogen mRNA, and angiotensin converting enzyme mRNA expression in the human eye: Evidence for an intraocular renin-angiotensin system
8. Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis
9. Vascular endothelial growth factor (VEGF) and its receptors
10. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
11. Vascular endothelial growth factor and its receptors in control and diabetic rat eyes
12. Upregulation of the vascular endothelial growth factor/vascular endothelial growth factor receptor system in experimental background diabetic retinopathy of the rat
13. The relation between expression of vascular endothelial growth factor and breakdown of the blood-retinal barrier in diabetic rat retinas
14. Immunohistochemical study of angiotensin-converting enzyme in human tissues using monoclonal antibodies
15. Cellular distribution of angiotensin-converting enzyme after myocardial infarction
16. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures
17. Localization of angiotensin converting enzyme in the ciliary epithelium of the rat eye
18. Neuromodulatory effects of the renin-angiotensin system on the cat electroretinogram
19. Disruption of blood retinal-barrier in experimental diabetic rats: An electron microscopic study
20. Hypoxia regulates vascular endothelial growth factor receptor KDR/Flk gene expression through adenosine A2 receptors in retinal capillary endothelial cells
21. Comparative analysis of vascular endothelial growth factor receptors on retinal and aortic vascular endothelial cells
22. Basic fibroblast growth factor induces expression of VEGF receptor KDR through a protein kinase C and p44/p42 mitogen-activated protein kinase-dependent pathway
23. Requirements for antihypertensive therapy in diabetic patients: Metabolic aspects
24. Effect of antihypertensive treatment on blood-retinal barrier permeability to fluorescein in hypertensive Type 1 (insulin-dependent) diabetic patients with background retinopathy
25. Protective effect of captopril on the blood-retina barrier in normotensive insulin-dependent diabetic patients with nephropathy and background retinopathy
26. Angiotensin II potentiates vascular endothelial growth factor-induced angiogenic activity in retinal microcapillary endothelial cells
27. Angiotensin II-stimulated vascular endothelial growth factor expression in bovine retinal pericytes
28. Neovascularization produced by angiotensin II