CD40/154 blockade and rejection of islet allografts in the streptozotocin and autoimmune diabetic rat

Pediatric Diabetes

Volumn 2, Issue 4, 2001, Pages 178-183

  Kover, Karen L ^a   Geng, Zhaohui ^a   Hess, Donna ^b   Benjamin, Christopher ^b   Moore, Wayne V ^a  

^a CHILDREN S MERCY HOSPITAL   (United States)

^b BIOGEN   (United States)

Author keywords

Anti CD154; Autoimmune diabetes; Islet transplantation

Indexed keywords

AH F 5; CD40 ANTIGEN; CD40 LIGAND MONOCLONAL ANTIBODY; GLUCAGON; STREPTOZOCIN;

ALLOGRAFT; ALLOTRANSPLANTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY BLOOD LEVEL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; DRUG EFFECT; GRAFT REJECTION; HAMSTER; IMMUNOSUPPRESSIVE TREATMENT; ISOGRAFT; KIDNEY CAPSULE; LYMPHOCYTE; LYMPHOCYTIC INFILTRATION; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; RAT; RAT STRAIN; RECURRENT DISEASE; SPLEEN CELL; STREPTOZOCIN DIABETES;

EID: 0035690077     PISSN: 1399543X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-5448.2001.20407.x     Document Type: Article

References (24)

1. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
2. Immune regulation by CD40-CD40-L interactions
3. Anti-CD154 therapy to prevent graft rejection
4. Central role for CD40/CD40 ligand (CD154) interactions in transplant rejection
5. CD40 and CD154 in cell-mediated immunity
6. Anti-CD 154 (CD40L) prevents recurrence of diabetes in islet isografts in the DRBB Rat
7. NOD mice have a generalized defect in their response to transplantation tolerance induction
8. Prolonged islet graft survival in NOD mice by blockade of the CD40-CD154 pathway of T-cell costimulation
9. Islet isolation from rodent pancreas
10. Intrathymic transplantation of allogeneic nonimmunogenic perinatal islet tissue does not induce donor-specific tolerance
11. CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway
12. Long-term acceptance of skin and cardiac allografts after blocking Cd40 and CD28 pathways
13. Costimulatory function and expression of CD40 ligand, CD80 and CD86 in vascularized murine cardiac allograft rejection
14. Blockade of the CD40-Cd40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival
15. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates
16. Treatment with humanized monoclonal antibody against CD154 prevents renal allograft rejection in nonhuman primates
17. Prevention of chronic rejection in mouse aortic allografts by combined treatment with CTLA4-Ig and anti CD40 ligand monoclonal antibody
18. Blockade of CD40 ligand-CD40 interaction impairs CD4+ T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone marrow transplantation
19. Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand
20. Tolerance to islet xenografts induced by dual manipulation of antigen presentation and costimulation
21. Induction of immunological tolerance to islet allografts
22. Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand
23. Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154
24. Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154