Effect of CpG DNA oligodeoxynucleotides and echinacea on the fungicidal activity of amphotericin B in a disseminated murine candidal infection model

Journal of Infectious Disease Pharmacotherapy

Volumn 4, Issue 4, 2001, Pages 55-66

  Hoffman, Holly L ^a   Ernst, Erika J ^a   Redford, Thomas W ^a   Klepser, Michael E ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Amphotericin; Candida albicans; CpG; Echinacea; Fungal; Immunotherapy; Murine

Indexed keywords

AMPHOTERICIN B; DNA; FUNGISONE; OLIGODEOXYNUCLEOTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFUNGAL ACTIVITY; ARTICLE; BODY BURDEN; CANDIDIASIS; CONTROLLED STUDY; CPG ISLAND; DISEASE ASSOCIATION; DNA SEQUENCE; ECHINACEA; MORTALITY; MOUSE; NEUTROPENIA; NONHUMAN; PROTEIN MOTIF; SURVIVAL;

EID: 0035685941     PISSN: 10687777     EISSN: None     Source Type: Journal    
DOI: 10.1300/J100v04n04_05     Document Type: Article

References (14)

1. Cure of murine candidiasis by recombinant soluble interleukin-4 receptor
2. Neutralization of IL-10 up-regulates nitric oxide production and protects susceptible mice from challenge with Candida albicans
3. Depletion of CD4+ (L3T4+) lymphocytes in vivo impairs murine host defense to Cryptococcus neoformans
4. Cytokine profiles associated with induction of the anticryptococcal cell-mediated immune response
5. Safety and efficacy of recombinant gamma interferon in the treatment of systemic sclerosis
6. Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production
7. Echinacea-induced cytokine production by human macrophages
8. Application of purified polysaccharides from cell cultures of the plant Echinacea purpurea to mice mediates protection against systemic infections with Listeria monocytogenes and Candida albicans
9. Application of purified polysaccharides from cell cultures of the plant Echinacea purpurea to test subjects mediates activation of the phagocyte system
10. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
11. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
12. Toxicity of Echinacea purpurea. Acute, subacute and genotoxicity studies
13. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge