In vitro effects of cholesteryl butyrate solid lipid nanospheres as a butyric acid pro-drug on melanoma cells: Evaluation of antiproliferative activity and apoptosis induction

Clinical and Experimental Metastasis

Volumn 18, Issue 8, 2000, Pages 663-673

  Salomone, B ^a   Ponti, R ^a   Gasco, M R ^b   Ugazio, E ^b   Quaglino, P ^a   Osella Abate, S ^a   Bernengo, M G ^a  

^a Department of Medical and Surgical Specialties   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

Apoptosis; Butyrate; Cell cycle; Cholesteryl butyrate; Drug delivery; Melanoma; Solid lipid nanospheres

Indexed keywords

BUTYRIC ACID; BUTYRIC ACID DERIVATIVE; CHOLESTEROL BUTYRATE; CHOLESTEROL ESTER; CYCLINE; FAS ANTIGEN; LIPOCORTIN 5; NANOPARTICLE; PRODRUG; PROPIDIUM IODIDE; PROTEIN BCL 2; REGULATOR PROTEIN; SOLID LIPID NANOPARTICLE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE G0 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG DELIVERY SYSTEM; DRUG MECHANISM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MELANOMA CELL; PHASE TRANSITION;

EID: 0035684864     PISSN: 02620898     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1013186331662     Document Type: Article

References (67)

1. Shorth-chain fatty acids in the human colon
2. Effects of sodium butyrate, a new pharmacological agent, on cells in culture
3. New stable butyrate derivatives alter proliferation and differentiation in human mammary cells
4. Effects of short-chain fatty acids on growth and differentiation in the human colon-cancer cell line HT29
5. Sodium butyrate induces apoptosis in human colonic tumor cell lines in a p53-independent pathway: Implications for the possible role of dietary fiber in the prevention of large-bowel cancer
6. Role of short-chain fatty acid in the prevention of colorectal cancer
7. Differentiating effect of sodium butyrate on human hepatoma coll lines PCL/PRF/5, HCC-T
8. Activity of pivaloyloxymethyl butyrate, a novel anticancer agent, on primary human tumor-colony-forming unit
9. Novel anticancer prodrugs of butyric acid. 2
10. Acetate and propionate potentiate the antiproliferative effect of butyrate on RBL-2H3 growth
11. Antitumor activity of tributyrin in murine melanoma model
12. Suppression of histone deacetylation in vivo and in vitro by sodium butyrate
13. Sodium butyrate inhibits histone deacetylation in culture cell
14. Butyric acid and its monosaccharide ester induce apoptosis in the HL60 cell line
15. Molecular regulation, of apoptosis: Genetic controls on cell death
16. Apoptosis in the pathogenesis and treatment of disease
17. Sodium butyrate inhibits c-myc splicing and interferes with signal trasduction in ovarian carcinoma cells
18. In vivo crypt surface hiper-proliferation is decreased by butyrate and increased by deoxycolate in normal rat colon: Associated in vivo effects on c-fos and c-jun expression
19. Bcl-2 expression regulates sodium butyrate induced apoptosis in human MCF-7 breast cancer cells
20. Butyrate modulates DANN-damage-induced p53 response by induction of p-53 independent differentiation and apoptosis
21. Antagonism of CD95 signaling blocks butyrate induction of apoptosis in young adult mouse colonic cells
22. Cancer cell sensitization to fas-mediated apoptosis by sodium butyrate
23. Clinical pharmacology of sodium butyrate in patients with acute leukemia
24. Effect of polar organic compounds on leukemic cells. Butyrate-induced partial remission of acute myelogenous leukaemia in a child
25. Cellular uptake and cytotoxicity of solid lipid nanospheres (SLN) incorporating doxorubicin or paclitaxel
26. Non-stealth and stealth solid lipid nanoparticles (SLN) carrying doxorubicin: Pharmacokinetics and tissue distribution after i.v. admistration to rats
27. Transmucosal transport of tobramycin incorporated in SLN after duodenal administration to rats-Part I-A pharmacokinetic study
28. Solid lipid nanoparticles in lymph and plasma after duodenal administration to rats
29. Biodistribution of stealth and non-stealth solid lipid nanospheres after intravenous administration to rats
30. Cholesteryl butyrate in solid lipid nanospheres as an alternative approach for butyric acid delivery
31. Solid lipid nanospheres from warm microemulsion
32. Determination of free, total, and esterified cholesterol by high-performance liquid chromatography
33. Annexin V affinity assay: A review on an apoptosis detection system based on phosphatidylserine oxposure
34. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis
35. Flow cytometric assessment of three different methods for the measurement of in vitro apoptosis
36. A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture
37. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
38. Modifications of cell cycle induced by DPR, a new platinum-triamine complex containing procaine
39. Effect of sodium butyrate and other differentiation inducers on poorly differentiated human ovarian adenocarcinoma cell lines
40. Sodium butyrate enhances STAT 1 expression in PLC/PRF/5 hepatoma cells and augments their responsiveness to interferon-alpha
41. Transient vs. prolonged histone hyperacetylation: Effects on colon cancer cell growth, differentiation, and apoptosis
42. Ingermann AR Effects of sodium butyrate on expression of members of the IGF-binding protein superfamily in human mammary epithelial cells
43. Histone deacetylase inhibitors decrease proliferation and modulate cell cycle gene expression in normal mammary epithelial cells
44. Butyrate as a model for 'gene-regulating chemoprevention and chemotherapy'
45. Modulation of cell cyclerelated protein expression by sodium butyrate in human non-small cell lung cancer cell lines
46. Arginine butyrate-induced susceptibility to ganciclovir in an Epstein-Barr virus-associated lymphoma
47. Extended therapy with intravenous arginine butyrate in patients with beta-hemoglobinopathies
48. A short-term trial of butyrate to stimulate fetal-globin-gene expression in the beta-globin disorders
49. Tributyrin, a stable and rapidly absorbed prodrug of butyric acid, enhances antiproliferative effects of dihydroxycholecalciferol in human colon cancer cells
50. Hyaluronic acid as drug delivery for sodium butyrate: Improvement of the anti-proliferative activity on a breast-cancer cell line
51. Prodrugs of butyric acid. Novel derivatives possessing increased aqueous solubility and potential for treating cancer and blood diseases
52. Novel mutual prodrug of retinoic and butyric acids with enhanced anticancer activity
53. Transmucosal transport of tobramycin incorporated in SLN after duodenal administration to rats. Part I - A pharmacokinetic study
54. Synthesis and biological evaluation of butanoate, retinoate, and bis(2,2,2-trichloroethyl)phosphate derivatives of 5-fiuoro-2′-deoxyuridine and 2′,5-difluoro-2′-deoxyuridine as potential dual action anticancer prodrugs
55. Chemotherapy and chemoimmunotherapy in disseminated malignant melanoma
56. Sodium butyrate induces apoptosis in human renal cell carcinoma cells and synergistically enhances their sensitivity to anti-Fas-mediated cytotoxicity
57. Sodium butyrate modulates p53 and Bcl-2 expression in human retinoblastoma cell lines
58. Butyrate and trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: Induction of cyclin D3 and p21 expression
59. Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent
60. Sodium butyrate modulates cell cycle-related proteins in HT29 human colonic adenocarcinoma cells
61. J. Sodium butyrate induces G2 arrest in the human breast cancer cells MDA-MB-231 and renders them competent for DNA rereplication
62. 1 arrest and apoptosis
63. Functional consequences of APO-1/Fas (CD95) antigen expression by normal and neoplastic hematopoietic cells
64. The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry
65. Bcl-2 initiates a new category of oncogenes: Regulator of cell death
66. The Fas death factor
67. Apoptosis cascade proteins are regulated in vivo by high intracolonic butyrate concentration: Correlation with colon cancer inhibition