Use of small animal models for screening immunoisolation approaches to cellular transplantation

Annals of the New York Academy of Sciences

Volumn 944, Issue , 2001, Pages 35-46

  Gill, Ronald G ^a  

^a UNIVERSITY OF COLORADO DENVER   (United States)

Author keywords

Cellular transplantation; Screening immunoisolation; Small animal models

Indexed keywords

ANTIGEN;

ANIMAL CELL; ANTIGEN PURIFICATION; BIOCOMPATIBILITY; CELL CONTACT; CELL ISOLATION; CELL MEMBRANE; CELL TRANSPLANTATION; CONFERENCE PAPER; CONTROLLED STUDY; DONOR; GRAFT REJECTION; HOST; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; NONHUMAN; SCREENING; TECHNOLOGY; TREATMENT PLANNING; XENOGRAFT;

ANIMALIA; RODENTIA;

EID: 0035683838     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2001.tb03821.x     Document Type: Conference Paper

References (44)

1. Bioengineering in development of the hybrid artificial pancreas
2. Effect of microencapsulation on oxygen distribution in islets organs
3. Why do nicroencapsulated islet grafts fail in the absence of fibrotic overgrowth?
4. Host reaction against empty alginate-polylysine microcapsules: Influence of preparation procedure
5. Effect of the alginate composition on the biocompatibility of alginate-polylysine microcapsules
6. Evidence that the effector mechanism of skin allograft rejection is antigen-specific
7. The specificity of rejection and the absence of susceptibility of pancreatic islet β cells to nonspecific immune destruction in mixed strain islets grafted beneath the renal capsule in the rat
8. The function of antigen-presenting cells in mice with severe combined immunodeficiency
9. An expanded population of natural killer cells in mice with severe combined immunodeficiency (SCID) lack rearrangement and expression of T cell receptor genes
10. T cell subsets and the recognition of MHC class
11. Immunobiology of tissue transplantation: A return to the passenger leukocyte concept
12. Role of the CD28 receptor in T-cell activation
13. Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule
14. Costimulation of T lymphocytes: The role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy
15. Direct and indirect pathways of immunity to pancreatic islet transplants
16. Constitutive class I-restricted exogenous presentation of self antigens in vivo
17. Evidence for an antigen-release induced cellular immune response against alginate-polylysine encapsulated islets
18. + helper T cells in the destruction of microencapsulated islet xenografts in NOD mice
19. + T cells and B cells
20. Xenogeneic humoral responses to islets transplanted in biohybrid diffusion chambers
21. Xenotransplantation of canine, bovine, and porcine islets in diabetic rats without immunosuppression
22. Biohybrid artificial pancreas: Long-term function of discordant islet xenografts in streptozotocin diabetic rats
23. Xenotransplantation of porcine and bovine islets without immunosuppression using uncoated alginate microspheres
24. Normalization of diabetes in spontaneously diabetic cynomologus monkeys by xenografts of microencapsulated porcine islets without immunosuppression
25. Parathyroid xenotransplantation without immunosuppression in experimental hypoparathyroidism: Long-term in vivo function following microencapsulation with a clinically suitable alginate
26. Destruction of rat islet cell monolayers by cytokines. Synergistic interactions of interferon-γ, tumor necrosis factor, lymphotoxin, and interleukin1
27. Islet cytotoxicity of interleukin 1. Influence of culture conditions and islet donor characteristics
28. Cytotoxic effects of cytokines on human pancreatic islet cells in monolayer culture
29. Cytotoxicity of human p I 7 interleukin-1 for pancreatic islets of Langerhans
30. Microencapsulated islet grafts in the BB/E rat: A possible role for cytokines in graft failure
31. Cytokine-induced functional suppression of microencapsulated rat pancreatic islets in vitro
32. The alginate-poly-L-lysine-alginate membrane: Evidence of a protective effect on microencapsulated islets of Langerhans following exposure to cytokines
33. CD4 T cells are both necessary and sufficient for islet xenograft rejection
34. Xenograft rejection of porcine islet-like cell clusters in immunoglobulin- or Fc-receptor γ-deficient mice
35. Macrophage-generated nitric oxide as cytotoxic factor in destruction of alginate-encapsulated islets
36. Cytotoxicity of peritoneal murine macrophages against encapsulated pancreatic rat islets: In vivo and in vitro studies
37. Local inflammatory response around diffusion chambers containing xenografts. Nonspecific destruction of tissues and decreased local vascularization
38. Infection by porcine endogenous retrovirus after islet xenotransplantation in SCID mice
39. Productive infection of primary human endothelial cells by pig endogenous retrovirus (PERV)
40. Porcine endogenous retrovirus (PERV) was not transmitted from transplanted porcine endothelial cells to baboons in vivo
41. No evidence of infection with porcine endogenous retrovirus in recipients of porcine islet-cell xenografts
42. Search for cross-species transmission of porcine endogenous retrovirus in patients with living pig tissue
43. No evidence of infection with porcine endogenous retrovirus in recipients of encapsulated porcine islet xenografts
44. Correction of diabetic NOD mice with insulinomas implanted within Baxter immunoisolation devices