The effect of DFMO induced uptake of [3H] putrescine on human glioma cells

Journal of Neuro-Oncology

Volumn 55, Issue 2, 2001, Pages 71-80

  Redgate, Edward S ^a   Alexander, Dominic ^a   Magra, T Ryan ^a   Henretty, Joseph S ^a   Patrene, Kenneth D ^a   Boggs, Sallie S ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Brain tumors; DFMO; Glioma; Human glioblastoma; Putrescine; Tritium

Indexed keywords

EFLORNITHINE; MD 71782A; POLYAMINE; PROTEIN SYNTHESIS INHIBITOR; PUTRESCINE; RADIOACTIVE MATERIAL; TRITIUM;

ANIMAL CELL; ARTICLE; BRAIN TUMOR; CANCER GROWTH; CANCER INHIBITION; CANCER SURVIVAL; CELL COUNT; CELL CYCLE; CELL KILLING; CELL PROLIFERATION; COLONY FORMING CELL; CONTROLLED STUDY; DRUG EFFECT; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; HYPOTHESIS; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; RADIATION DOSE; RAT; TUMOR CELL; TUMOR CELL LINE;

BIOLOGICAL TRANSPORT; BRAIN NEOPLASMS; CELL ADHESION; CELL DIVISION; COLONY-FORMING UNITS ASSAY; EFLORNITHINE; ENZYME INHIBITORS; GLIOMA; HUMANS; ORNITHINE DECARBOXYLASE; PUTRESCINE; TRITIUM; TUMOR CELLS, CULTURED;

EID: 0035681239     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1013348227892     Document Type: Article

References (20)

1. Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy
2. Effects of (2R, 5R)-6-heptyne-2,5-diamine, a potent inhibitor of L-ornithine decarboxylase, on rat hepatoma cells cultured in vitro
3. Ornithine decarboxylase as an enzyme target for therapy
4. Depletion of 9L rat brain tumor cell polyamine content by treatment with D,L-alpha-difluoromethylornithine inhibits proliferation and the G1 to S transition
5. Tumor selective enhancement of radioactivity uptake in mice treated with alpha-difluoromethylornithine prior to administration of 14C-putrescine
6. Effect of D,L-alpha-difluoromethylornithine (DFMO) enhanced [3H]putrescine uptake on 9L tumor cell growth and colony forming efficiency
7. Difluoromethylornithine enhanced uptake of tritiated putrescine in 9L rat brain tumors
8. Enhanced uptake of [3H] spermidine by 9L rat brain tumors after direct intratumoral infusion of inhibitors of enzymes of the polyamine biosynthetic pathway
9. Polyamines in brain tumor therapy
10. Morphological and immunocytochemical characteristics of human tumor cell lines for use in a disease-oriented anticancer drug screen
11. Potentials and limitations of a clonogenic cell assay for human brain tumors
12. Parameters influencing the efficiency of the thymidine kinase/ganciclovir strategy in human glioblastoma cell lines
13. Morphologic, immunologic, biochemical, and cytogenetic characteristics of the human glioblastoma-derived cell line, SNB-19
14. Optimizing limiting dilution assays: Frequency and 'ability' measurements of haemopoietic progenitor cells
15. Limiting dilution assays for the determination of immunocompetent cell frequencies. III. Validity tests for the single-hit Poisson model
16. Combining D,L-alpha-difluoromethylornithine with [3h] thymidine increases killing of rat gliosarcoma cells in vitro
17. On the subcellular localization of the polyamines
18. Effect of polyamine deprivation on the survival of intracranial glioblastoma bearing rats
19. Polyamines as targets for therapeutic intervention
20. Treatment of recurrent gliomas with eflornithine