Genetic polymorphisms in the promoter and 5′ UTR region of the Fc α receptor (CD89) are not associated with a risk of IgA nephropathy

Journal of Human Genetics

Volumn 46, Issue 12, 2001, Pages 694-698

  Narita, I ^a   Goto, S ^a   Saito, N ^a   Sakatsume, M ^a   Jin, S ^a   Omori, K ^a   Gejyo, F ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

Author keywords

5 UTR region; Fc receptor; Gene polymorphism; Haplotype; IgA nephropathy; Promoter

Indexed keywords

ANTIGEN; CD89 ANTIGEN; DNA; FC RECEPTOR; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA POLYMORPHISM; DNA SCREENING; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENOTYPE; GLOMERULOPATHY; HAPLOTYPE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN A NEPHROPATHY; KIDNEY BIOPSY; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PROMOTER REGION; RISK FACTOR; TRANSCRIPTION INITIATION;

5' UNTRANSLATED REGIONS; ALLELES; ANTIGENS, CD; BASE SEQUENCE; DNA; GENE FREQUENCY; GENOTYPE; GLOMERULONEPHRITIS; GLOMERULONEPHRITIS, IGA; HUMANS; KIDNEY DISEASES; LINKAGE DISEQUILIBRIUM; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); RECEPTORS, FC; RISK FACTORS;

EID: 0035674118     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100380170002     Document Type: Article

References (16)

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4. IgA nephropathy, the most common cause of glomerulonephritis, is linked to 6q22-23
5. Stimulation of Fc(α) receptors induces tyrosine phosphorylation of phospholipase C-γ(1), phosphatidylinositol phosphate hydrolysis, and Ca2+ mobilization in rat and human mesangial cells
6. Down-regulation of FcaR receptors on blood cells of IgA nephropathy patients: Evidence for a negative regulatory role of serum IgA
7. Evidence for genetic factors in the development and progression of IgA nephropathy
8. Fc α R expression on polymorphonuclear leukocyte and superoxide generation in IgA nephropathy
9. Glomerular Fc α R expression and disease activity in IgA nephropathy
10. Fcα receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropathy (Berger's disease). Evidence for pathogenic soluble receptor-Iga complexes in patients and CD89 transgenic mice
11. Dysfunctions of Fc alpha receptors by blood phagocytic cells in IgA nephropathy
12. Familial clustering of IgA nephropathy: Further evidence in an Italian population
13. Identification and characterization of the promotor for the gene encoding the human myeloid IgA Fc receptor (FcaR, CD89)
14. The detection of linkage disequilibrium between closely linked markers: RFLPs at the AI-CIII apolipoprotein genes
15. Polymorphism in promotor region of Fca receptor gene in patients with IgA nephropathy
16. Polymorphism in the Iα germ-line transcript regulatory region and IgA productivity in patients with IgA nephropathy