'Slave' metabolites and enzymes. A rapid way of delineating metabolic control

European Journal of Biochemistry

Volumn 267, Issue 7, 2000, Pages 1889-1893

  Teusink, Bas ^a,c   Westerhoff, Hans V ^a,b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c TNO   (Netherlands)

Author keywords

Bioengineering; Glycolysis; Metabolic control analysis; Metabolic regulation; Modeling

Indexed keywords

ENZYME;

ARTICLE; CATALYSIS; CONCENTRATION (PARAMETERS); ENZYME KINETICS; GLYCOLYSIS; MATHEMATICAL MODEL; METABOLIC REGULATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

CATALYSIS; ENZYMES; GLYCOLYSIS; KINETICS; SACCHAROMYCES CEREVISIAE;

EID: 0034105138     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01220.x     Document Type: Article

References (31)

1. Stryer (1988) Biochemistry. Freeman, New York, USA.
2. Kell, D.B. & Westerhoff, H.V. (1986) Metabolic control theory: its role in microbiology and biotechnology. FEMS Microbiol. Rev. 39, 305-320.
3. Fell, D.A. (1992) Metabolic control analysis: a survey of its theoretical and experimental development. Biochem. J. 286, 313-330.
4. Kacser, H., Burns, J.A. & Fell, D.A. (1995) The control of flux. Biochem. Soc. Trans. 23, 341-366.
5. Heinrich, R. & Schuster, S. (1996) The Regulation of Cellular Systems. Chapman & Hall. New York, USA.
6. Teusink, B., Baganz, F., Westerhoff, H.V. & Oliver, S.G. (1998) Metabolic control analysis as a tool in the elucidation of the function of novel genes. In Methods in Microbiol (Tuite, M. F. & Brown, A. J. P., eds), pp. 297-336. Academic Press, New York.
7. Kacser, H. & Burns, J.A. (1973) The control of flux. Symp Soc. Exp. Biol. 27, 65-104.
8. Westerhoff, H.V. & Chen, Y. (1984) How do enzyme activities control metabolite concentrations? Eur. J. Biochem. 142, 425-430.
9. Rohwer, J.M., Schuster, S. & Westerhoff, H.V. (1996) How to recognize monofunctional units in a metabolic system. J. Theor. Biol. 179, 213-228.
10. Kholodenko, B.N., Schuster, S., Rohwer, J.M., Cascante, M. & Westerhoff, H.V. (1995) Composite control of cell function: metabolic pathways behaving as single control units. FEBS Lett. 368, 1-4.
11. Hofmeyr, J.-H.S., Cornish-Bowden, A. & Rohwer, J.M. (1993) Taking enzyme kinetics out of control; putting control into regulation. Eur. J. Biochem. 212, 833-837.
12. Hofmeyr, J.-H.S. & Cornish-Bowden, A. (1996) Co-response analysis: a new experimental strategy for metabolic control analysis. J. Theor. Biol. 182, 371-380.
13. Rapoport, T.A., Heinrich, R., Jacobasch, G. & Rapoport, S. (1974) A linear steady-state treatment on enzymatic chains. A mathematical model of glycolysis of human erythrocytes. Eur. J. Biochem. 42, 107-120.
14. Bakker, B.M., Michels, P.A.M., Opperdoes, F.R. & Westerhoff, H.V. (1997) Glycolysis in bloodstream form Trypanosoma brucei can be understood in terms of the kinetics of the glycolytic enzymes. J. Biol. Chem. 272, 3207-3215.
15. Hofmeyr, J.-H.S. & Cornish-Bowden, A. (1991) Quantitative assesment of regulation in metabolic systems. Eur. J. Biochem. 200, 223-236.
16. Fell, D.A. (1997). Understanding the Control of Metabolism. Portland Press, London, UK.
17. Otto, A., Przybylski, F., Nissler, K., Schellenberger, W. & Hofmann, E. (1986) Kinetic effects of fructose 1,6-bisphosphate on yeast phospho-fructokinase. Biomed. Biochim. Acta 45, 865-875.
18. Thevelein, J.M. & Hohmann, S. (1995) Trehalose synthase: guard to the gate of glycolysis in yeast? Trends Biochem. Sci. 20, 3-10.
19. Teusink, B., Walsh, M.C., Van Dam, K. & Westerhoff, H.V. (1998) The danger of metabolic pathways with turbo design. Trends Biochem. Sci. 23, 162-169.
20. Schaaff, I., Heinisch, J. & Zimmermann, F.K. (1989) Overproduction of glycolytic enzymes in yeast. Yeast 5, 285-290.
21. Galazzo, J.L. & Bailey, J.E. (1990) Fermentation pathway kinetics and metabolic flux control in suspended and immobilized Saccharomyces cerevisiae. Enz. Microb. Technol. 12, 162-172.
22. Cortassa, S. & Aon, M.A. (1994) Metabolic control analysis of glycolysis and branching to ethanol production in chemostat cultures of Saccharomyces cerevisiae under carbon, nitrogen, or phosphate limitations. Enz. Microb. Technol. 16, 761-770.
23. Cortassa, S. & Aon, M.A. (1997) Distributed control of the glycolytic flux in wild-type cells and catabolite repression mutants of Saccharomyces cerevisiae growing in carbon-limited chemostat cultures. Enz. Microb. Technol. 21, 596-602.
24. Teusink, B. (1999) Exposing a complex metabolic system: glycolysis in Saccharomyces cerevisiae. PhD Thesis, University of Amsterdam, Amsterdam, the Netherlands.
25. Kahn, D. & Westerhoff, H.V. (1993) The regulatory strength: how to be precise about regulation and homeostasis. Biotheor. Acta 41, 85-96.
26. Hofmeyr, J.-H.S. (1995) Metabolic regulation: a control analytic perspective. J. Bioenerget. Biomembr. 27, 479-490.
27. Thomas, S. & Fell, D.A. (1998) A control analysis exploration of the role of ATP utilisation in glycolytic-flux control and glycolytic-metabolite-concentration regulation. Eur. J. Biochem. 15, 956-967.
28. Westerhoff, H.V., Teusink, B., Mensonides, F., Reijenga, K.A., Esgalhado, E., Somsen, O.J.G., Van Heeswijk, W.C., Boogerd, F.C., Bruggeman, F.J. & Snoep, J.S. (2000) Metabolic Control from the Back Benches. Biochemistry towards Biocomplexity. In Technological and Medical Implications of Metabolic Control Analysis (Cornish-Bowden, A. & Cardenas, M.L, eds), pp. 235-242. Kluwer Academic Publishers, Dordrecht, the Netherlands.
29. Schuster, S. & Schuster, R. (1992) Decomposition of biochemical reaction systems according to flux control insusceptibility. J. Chim. Phys. 89, 1887-1910.
30. Schuster, S., Kholodenko, B.N. & Westerhoff, H.V. (2000) Cellular information transfer regarded from a stoichiometry and control analysis perspective. Biosystems in press.
31. Cornish-Bowden, A. & Hofmeyr, J.-H.S. (1994) Determination of control coefficients in intact metabolic systems. Biochem. J. 298, 367-375.