Solid phase synthesis of diamino-substituted pyrimidines

European Journal of Organic Chemistry

Volumn , Issue 24, 2001, Pages 4737-4741

  Barillari, Caterina ^a   Barlocco, Daniela ^b   Raveglia, Luca F ^a  

^a GSK   (Italy)

^b Istituto di Chimica e Biochimica GRonzoni   (Italy)

Author keywords

Combinatorial chemistry; Nucleophilic substitution; Solid phase synthesis

Indexed keywords

2 METHYL N (4 PHENYLBUTYL)PYRIMIDINE 4,6 DIAMINE; AMINE; AROMATIC COMPOUND; DIAMINE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; REACTION ANALYSIS; SOLID;

EID: 0035664748     PISSN: 1434193X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-0690(200112)2001:24<4737::AID-EJOC4737>3.0.CO;2-1     Document Type: Article

References (24)

1. A. G. Arvanitis, P. J. Gilligan, R. J. Chorvat, R. S. Cheeseman, T. E. Christos, R. Bakthavatchalam, J. P. Beck, A. J. Cocuzza, F. W. Hobbs, R. G. Wilde, C. Arnold, D. Chidester, M. Curry, L. He, A. Hollis, J. Klaczkiewicz, P. J. Krenitsky, J. P. Rescinito, E. Scholfield, S. Culp, E. B. De Souza, L. Fitzgerald, D. Grigoriadis, S. W. Tam, Y. N. Wong, S.-M. Huang, H. L. Shen, J. Med. Chem. 1999, 42, 805-818.
2. P. Franchetti, L. Cappellacci, G. Abu Sheikha, M. Grifantini, A. G. Loi, A. De Montis, M. G. Spiga, P. La Colla, Nucleosides Nucleotides 1995, 14, 607-610.
3. K. E. Kinnamon, R. R. Engle, B. T. Poon, W. Y. Ellis, J. W. McCall, M. T. Dzimianski, Ann. Trop. Med. Parasitol. 1999, 93, 851-858.
4. H. Vorbrueggen, Adv. Heterocyclic Chem. 1990, 49, 117-192.
5. D. Obrecht, C. Abrecht, A. Grieder, J. M. Villalgordo, Helv. Chim. Acta 1997, 80, 65-72.
6. T. Masquelin, D. Sprenger, R. Baer, F. Gerber, Y. Mercadal, Helv. Chim. Acta 1998, 81, 646-659.
7. C. Zucca, P. Bravo, A. Volonterio, M. Zanda, A. Wagner, C. Mioskowski, Tetrahedron Lett. 2001, 42, 1033-1035.
8. F. Guillier, P. Roussel, H. Moser, P. Kane, M. Bradley, Chem. Eur. J. 1999, 5, 3450-3458.
9. R. Di Lucrezia, I. H. Gilbert, C. D. Floyd, J. Comb. Chem. 2000, 3, 249-253.
10. I. W. James, Tetrahedron 1999, 55, 4855-4946.
11. C. Gibson; H. Kessler, Tetrahedron Lett. 2000, 41, 1725-1728.
12. B. A. Dressman, L. A. Spangle, S. W. Kaldor, Tetrahedron Lett. 1996, 37, 937-940.
13. D. M. Dixit, C. C. Leznoff, Isr. J. Chem. 1978, 17, 248-252.
14. C. Hansch, A. Leo, Substituent Constants for Correlation Analysis in Chemistry and Biology John Wiley & Sons, 1979.
15. Z. Budesinsky, Collect. Czech. Chem. Commun. 1949, 14, 223-235.
16. G. Reginat, E. Grandini, A. Paio, P. Seneci, S. Gehanne, Combinatorial Chemistry 2000. New Horizons for accelerated discovery in the Chemical and Biological Sciences London, UK, 2000, Poster Glaxo-Wellcome.
17. C. W. Whitehead, J. J. Traverso, J. Am. Chem. Soc. 1958, 2185-2189.
18. J. von Braun, Ber. Dtsch. Chem. Ges., 1937, 70B, 979-985.
19. J. C. Schaeffer, A. K. Cho, J. F. Fischer, J. Pharm. Sci. 1976, 65, 122-126.
20. C. A. H. Rasmussen, H. C. Van der Plas, P. Grotenhuis, A. Koudijs, J. Heterocycl. Chem. 1978, 15, 1121-1125.
21. Y. Fumio, S. Fukazawa, J. Chem. Soc., Chem. Commun. 1972, 9, 503-504.
22. S. Takahashi, T. Yatsunami, K. Shudo, T. Okamoto, K. Yamada, Y. Isogai, Chem. Pharm. Bull. 1978, 26, 2286-2287.
23. E. A. Arutyunyan, V. I. Gunar, S. I. Zav'yalov, Ser. Khim. 1970, 4, 904-909.
24. H. C. Van der Plas, B. Zuurdeeg, Recl. Trav. Chim. Pays-Bas 1969, 88, 426-438.