Gastrimmune-induced antigastrin-17 antibodies inhibit acid secretion in a rat fistula model

Alimentary Pharmacology and Therapeutics

Volumn 15, Issue 12, 2001, Pages 1981-1988

  Smith, A M ^a   Morris, T ^a   Justin, T ^a   Michaeli, D ^b   Watson, S A ^a  

^a NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^b Aphton Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; DIPHTHERIA TOXOID; GASTRIMMUNE; GASTRIN 17; PENTAGASTRIN;

ACID SECRETION; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; IMMUNIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH FISTULA;

ANIMALS; ANTIBODIES; CANCER VACCINES; DIPHTHERIA TOXOID; DISEASE MODELS, ANIMAL; FEMALE; GASTRIC ACID; GASTRIC FISTULA; GASTRINS; GASTROINTESTINAL AGENTS; IMMUNIZATION; MALE; PENTAGASTRIN; RATS; RATS, WISTAR;

EID: 0035663018     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.2001.01081.x     Document Type: Article

References (21)

1. Gastrin
2. A monoclonal antibody to somatostain with potent in vivo immunoneutralising activity
3. Effect of gastrin monoclonal antibody 28.2 on acid response to chemical vagal stimulation in rats
4. Tumour therapy with monoclonal antibodies
5. Gastrimmune inhibits the primary and secondary growth of 2 rat colon carcinomas
6. Active immunisation against gastrin-17 with an N-terminal derived immunogen inhibits gastric and duodenal lesions in rats
7. Glycine-extended gastrin potentiates gastrin-stimulated gastric acid secretion in rats
8. Glycine-extended gastrin synergizes with gastrin 17 to stimulate acid secretion in gastrin-deficient mice
9. Glycine-extended progastrin processing intermediates induce H+,K(+)-ATPase alpha-subunit gene expression through a novel receptor
10. Gastrimmune raises antibodies that neutralise amidated and glycine-extended gastrin-17 and inhibit the growth of colon cancer
11. Gastrimmune reduces lung metastases in a human colorectal model
12. Clinical outcome of advanced colorectal cancer patients treated with the anti-gastrin immunogen, Gastrimmune
13. Evidence for reflex adrenergic inhibition of acid secretion in the conscious rat
14. A comparison of an anti-gastrin antibody and cytotoxic drugs in the therapy of human gastric ascites in SCID mice
15. Pre-clinical evaluation of the Gastrimmune immunogen alone and in combination with 5-fluorouracil/leucovorin in a rat colorectal cancer model
16. Differential kinetics for immunoneutralization of circulating gastrin by gastrin monoclonal antibody and its Fab1 fragment in rats
17. Phase I/II study of G17-DT, an anti-gastrin immunogen, in advanced colorectal cancer
18. Processing and proliferative effects of human progastrin in transgenic mice
19. Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation
20. Gastrin and colorectal cancer: A prospective study