A comparison of an anti-gastrin antibody and cytotoxic drugs in the therapy of human gastric ascites in SCID mice

International Journal of Cancer

Volumn 81, Issue 2, 1999, Pages 248-254

  Watson, Sue A ^a   Michaeli, Dov ^c   Grimes, Stephen ^c   Morris, Teresa M ^a   Varro, Andrea ^b   Clarke, Philip A ^a   Smith, Andrew M ^a   Justin, Tim A ^a   Hardcastle, Jack D ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c Aphton Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [[2 [2 [[(2 ADAMANTYLOXY)CARBONYL]AMINO] 3 (1H INDOL 3 YL) 2 METHYLPROPIONAMIDO] 1 PHENYLETHYL]AMINO] 4 OXOBUTYRIC ACID MEGLUMINE; ANTIGEN; CHOLECYSTOKININ B RECEPTOR ANTAGONIST; CYTOTOXIC AGENT; FLUOROURACIL; FOLINIC ACID; GASTRIMMUNE; GASTRIN; GASTRIN ANTAGONIST; PROGASTRIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASCITES CELL; CANCER IMMUNOTHERAPY; CANCER THERAPY; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; DRUG TARGETING; EXPERIMENTAL NEOPLASM; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; STOMACH CANCER; SUBCUTANEOUS DRUG ADMINISTRATION; TREATMENT OUTCOME;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ASCITES; CANCER VACCINES; DIPHTHERIA TOXOID; FLUOROURACIL; GASTRINS; HUMANS; LEUCOVORIN; MICE; MICE, SCID; SEVERE COMBINED IMMUNODEFICIENCY; STOMACH NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0032963832     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19990412)81:2<248::AID-IJC14>3.0.CO;2-G     Document Type: Article

References (32)

1. ASAO, T., SHIBATA, H.R., BATIST, G. and BRODT P., Eradication of hepatic metastases of carcinoma H-59 by combination chemoimmunotherapy with liposomal muramyl tripeptide, 5-fluorouracil and leucovorin. Cancer Res., 52, 6254-6257 (1992).
2. BALDWIN, G.S., Binding of progastrin fragments to the 78kDa gastrin-binding protein. FEBS Lett., 359, 97-100 (1995).
3. FINLEY, G.G., KOSKI, R.A., MELHAM, M.F., PIPAS, J.M. and MEISLER, A.I., Expression of the gastrin gene in the normal human colon and colorectal adenocarcinoma. Cancer Res., 53, 2919-2926 (1993).
4. HUGHES, J., BODEN, P., COSTALL, B., DOMENEY, A., KELLY, E. and HORWELL, D.C., Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity. Proc. nat. Acad. Sci. (Wash.), 87, 6728-6732 (1990).
5. ITO, M., MATSUI, T., TANIGUCHI, T., TSUKAMOTO, T., MURAYAMA, T., ARIMA, N., NAKATA, H., CHIBA, T. and CHIHARA, K., Functional characterisation of a human cholecystokinin-B receptor. J. biol. Chem., 268, 18300-18305 (1993).
6. IWASE, K., EVERS, B.M., HELLMICH, M.R., GUO, Y.S., HIGASHIDE, S., KIM, H.J. and TOWNSEND, C.M., Regulation of growth of human gastric cancer by gastrin and glycine-extended progastrin. Gastroenterology, 113, 782-790 (1997).
7. JESSOP, N.W. and HAY, R.J., Characterisation of two rat pancreatic exocrine cell lines derived from transplantable tumours. In Vitro, 16, 212 (1980).
8. KOBORI, O., VUILLOT, M.T. and MARTIN, F., Growth responses of rat stomach cancer cells to gastroentero pancreatic hormones. Int. J. Cancer, 30, 65-67 (1982).
9. KOPIN, A.S., LEE, Y.M., MCBRIDGE, E.W., MILLER, L.J., LU, M., LIN, H.Y., KOLAKOWSKI, L.F. and BEINBORN, M., Expression cloning and characterization of the canine parietal cell gastrin receptor. Proc. nat. Acad. Sci. (Wash.), 89, 3605-3609 (1992).
10. KUMAMOTO, T., Gastrin receptors in human gastric scirrhous carcinoma. Gastroenterol. Jpn., 23, 384-389 (1988).
11. MAKISHIMA, R., LARKIN, P., MICHAELI, D. and GAGINELLA T.S., Active immunisation against gastrin-17 with an N-terminal derived immunogen inhibits gastric and duodenal lesions in rats. Gastroenterology, 106, a824 (1994).
12. MOYER, M.P., ARMSTRONG, A., BRADLEY,-AUST, J., LEVINE, B.A. and SIRENK, K.R., Effects of gastrin, glutamine and somatostatin on the in vitro growth of normal and malignant human gastric mucosal cells. Arch. Surg., 121, 285-288 (1986).
13. NEMETH, J., TAYLOR, B., PAUWELS, S., VARRO, A. and DOCKRAY, G.J., Identification of progastrin derived peptides in colorectal carcinoma extracts. Gut, 34, 90-95 (1993).
14. NEMETH, J., VARRO, A., BRIDSON, J., WALKER, R. and DOCKRAY, G.J., Increased tissue concentrations of the gastrin precursor in patients treated with omeprazole. Europ. J. Cancer 22, 638-644 (1992).
15. OCHIAI, A., YASUI, W. and TAHARA, E., Growth-promoting effect of gastrin on human gastric carcinoma cell line, TMK-1. Jpn. J. Cancer Res., (Gann) 76, 1064-1071 (1985).
16. REMY-HEINTZ, N., PERRIER-MEISSONNIER, NONOTTE, I., LALIBERTE, M.F., CHEVILLARD, C., LABOISSE, C. and BALI, J.P., Evidence for autocrine growth stimulation by a gastrin/CCK-like peptide of the gastric cancer HGT-1 cell line. Mol. cell. Endocrinol., 303, 834-838 (1993).
17. SEVA, C., DICKINSON, C.J. and YAMADA, T., Growth-promoting effects of glycine-extended progastrin. Science, 265, 410-412 (1994).
18. SINGH, P., XU, Z., DAI, B., RAJARAMAN, S., RUBIN, N. and DHRUVA B., Incomplete processing of progastrin expressed by human colon cancer cells: role of noncarboxyamidated gastrins. Amer. J. Physiol., 266, G459-G468 (1994).
19. SINGH, P., RAE-VENTER, B. and TOWNSEND, C.M., Gastrin receptors in normal and malignant gastrointestinal mucosa: age associated changes. Amer. J. Physiol., 249, G761-G769 (1985).
20. STEPAN, V.M., SAWADA, M., YAMADA, T., and DICKINSON, C.J., Glycine-extended gastrin exerts growth-promoting effects on colon cancer cell lines. (Abstr) Gastroenterology, 110, A1122 (1996).
21. SYKES, R., ROBINSON, G., and WATSON, S.A., Gastrin receptor localisation in normal and neoplastic gastric mucosa. Gut. 35, A1680 (1994).
22. VAN-SOLINGE, W.W., NIELSEN, F.C., FRIIS-HANSEN, L., FALKMER, U.G. and REHFELD, J.F., Expression but incomplete maturation of progastrin in colorectal carcinomas. Gastroenterology, 104, 1099-1107 (1993).
23. VAN-SOLINGE, W.W. and REHFELD, J.F., Co-transcription of the gastrin and cholecystokinin genes with selective translation of gastrin mRNA in a human gastric carcinoma cell line. FEBS Lett., 309, 47-50 (1992).
24. WATSON, S.A., CLARKE, P.A., VARRO, A., MICHAELI, D., GRIMES, S., MCWILLIAMS, D., SETH, R., CAPLIN, M. and HARDCASTLE, J.D., Expression of gastrin/CCKB receptor isoforms in gastrointestinal tumour cells: relationships to gastrin secretion. Proc. AACR (Abstract) (1997).
25. WATSON, S.A., CLIFFORD, T.L. and STEELE, R.J.C., Inhibitory effects of the gastrin receptor antagonist CR2093 on basal, gastrin-stimulated and growth factor-stimulated growth of the rat pancreatic cell line AR42J. Anti-Cancer Drugs, 5, 591-597 (1994).
26. WATSON, S.A., DURRANT, L.G., CROSBIE, J.D. and MORRIS, D.L., The in vitro growth response of primary human colorectal and gastric cancer cells to gastrin. Int. J. Cancer, 43, 692-696 (1989).
27. WATSON, S.A., DURRANT, L.G. and MORRIS, D., Gastrin: Growth-enhancing effects on human gastric and colonic tumour cells. Brit. J. Cancer, 59, 554-558 (1989).
28. WATSON, S.A., DURRANT, L.G., WENCYK, P.M., WATSON, A.L. and MORRIS, D.L., Intracellular gastrin in human gastrointestinal tumour cells. J. nat. Cancer Inst., 83, 866-872 (1991).
29. WATSON S.A., MICHAELI D., GRIMES, S., MORRIS, T.M., CROSBEE, D., WILKINSON, M., ROBINSON, G., ROBERTSON, J.F.R. and STEELE R.J.C., Anti-gastrin antibodies raised by gastrimmune inhibit growth of the human colorectal tumour, AP5. Int. J. Cancer., 61, 233-240 (1995).
30. WATSON, S.A., MICHAELI, D., GRIMES, S., MORRIS, T.M., ROBINSON, G., VARRO, A., JUSTIN, T.A. and HARDCASTLE, J.D., Gastrimmune raises antibodies that neutralize amidated and glycine-extended gastrin-17 and inhibit the growth of colon cancer. Cancer Res., 56, 880-885 (1996).
31. WEINSTOCK, J., and BALDWIN, G.S., Binding of gastrin-17 to human gastric carcinoma cell lines. Cancer Res., 48, 932-937 (1988).
32. WHELAN, S.L., PARKIN, D.M. and MASUYER, E., Trends in cancer incidence and mortality. IARC Scientific Publications 12, Lyon (1993).