Enteric-release glyceryl trinitrate in active Crohn's disease: A randomized, double-blind, placebo-controlled trial

Alimentary Pharmacology and Therapeutics

Volumn 15, Issue 12, 2001, Pages 1867-1873

  Hawkes, N D ^a   Richardson, C ^a   Ch'Ng, C L ^e   Green, J T ^e   Evans, B K ^b   Williams, J ^c   Rhodes, P ^f   Rhodes, J ^a   Swift, G L ^d   Thomas, G A O ^a   Hawthorne, A B ^a   Kingham, J G C ^e   Mayberry, J F ^g  

^a UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^b St Mary's Pharmaceutical Unit   (United Kingdom)

^c CARDIFF UNIVERSITY   (United Kingdom)

^d LLANDOUGH HOSPITAL   (United Kingdom)

^e SINGLETON HOSPITAL   (United Kingdom)

^f ROYAL CHILDREN'S HOSPITAL   (Australia)

^g LEICESTER GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EUDRAGIT; GELUCIRE; GLYCERYL TRINITRATE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROHN DISEASE; DISEASE ACTIVITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FORMULATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PAIN; PATHOGENESIS; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SUSTAINED RELEASE PREPARATION;

ADMINISTRATION, ORAL; ADULT; CROHN DISEASE; DIZZINESS; DOUBLE-BLIND METHOD; EXANTHEMA; FEMALE; FLUSHING; HEADACHE; HUMANS; MALE; MIDDLE AGED; NAUSEA; NITROGLYCERIN; TABLETS, ENTERIC-COATED; TREATMENT OUTCOME; VASODILATOR AGENTS;

EID: 0035659281     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.2001.01120.x     Document Type: Article

References (19)

1. Pathogenesis of Crohn's disease: Multi-focal gastrointestinal infarction
2. A ferret model of acute multifocal gastrointestinal infarction
3. Crohn's disease and anastomotic recurrence: Microvascular ischaemia and anastomotic healing in an animal model
4. Smoking: Good or bad for inflammatory bowel disease?
5. Impaired endothelium-dependent vasorelaxation in peripheral vasculature of patients with thromboangiitis obliterans (Buerger's disease)
6. Microcirculatory characteristics in patients with Buerger's disease
7. Nitric oxide: Physiology, pathophysiology and pharmacology
8. Differential changes in nitric oxide synthase activity in ulcerative colitis and Crohn's disease
9. Diffusion of nitric oxide and scavenging by blood in the vasculature
10. Low basal and stimulated release of nitric oxide in atherosclerotic epicardial coronary arteries
11. The short inflammatory bowel disease questionnaire: A quality of life instrument for community physicians managing inflammatory bowel disease. CCRPT Investigators. Canadian Crohn's relapse prevention trial
12. Colonic release of 5-aminosalicylic acid from an oral preparation in active ulcerative colitis
13. A pharmacokinetic study of sulphasalazine and two new formulations of mesalazine
14. An oral formulation of nicotine for release and absorption in the colon: Its development and pharmacokinetics
15. Uniformity of content
16. Clinical pharmacokinetics of nitrates
17. Topical glyceryl trinitrate in the treatment of chronic anal fissure
18. A randomised prospective double blind placebo controlled trial of glyceryl trinitrate ointment in the treatment of anal fissure
19. Randomised controlled trial shows that glyceryl trinitrate heals anal fissures, higher doses are not more effective and there is a high recurrence rate