New approaches to inducing the death of alloreactive lymphocytes

Clinical and Experimental Immunology

Volumn 126, Issue 3, 2001, Pages 371-373

  Krams, S M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Fas; T cells; Tolerance

Indexed keywords

BISINDOLYLMALEIMIDE; CD3 ANTIGEN; CD40 ANTIGEN; CYCLOSPORIN A; FAS ANTIGEN; FAS LIGAND; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 12; INTERLEUKIN 2; RAPAMYCIN; STAUROSPORINE DERIVATIVE;

ADJUVANT ARTHRITIS; ALLERGIC ENCEPHALITIS; ALLOIMMUNITY; APOPTOSIS; CELL ACTIVATION; CELL DEATH; CELL INFILTRATION; CELL INVASION; CELL POPULATION; EDITORIAL; GRAFT REJECTION; GRAFT SURVIVAL; HOMEOSTASIS; HUMAN; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; LYMPHOCYTE; MAJOR HISTOCOMPATIBILITY COMPLEX; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; FAS LIGAND PROTEIN; HUMANS; IMMUNE TOLERANCE; ISOANTIGENS; LYMPHOCYTES; MEMBRANE GLYCOPROTEINS; TRANSPLANTATION IMMUNOLOGY;

EID: 0035655952     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2001.01737.x     Document Type: Editorial

References (20)

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2. IL-12 antagonism wnhances apoptotic death of T cells within hepatic allografts from Flt3 ligand-trated donors and promotes graft acceptance
3. Apoptosis of T lymphocytes in liver and/or small bowel allografts during tolerance induction
4. Posttransplant administration of donor leukocytes induces long-term acceptance of kidney or liver transplants by an activation-associated immune mechanism
5. Accelerating the induction of Fas-mediated T cell apoptosis: A strategy for transplant tolerance
6. Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases
7. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
8. Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen
9. A role for CD95 ligand in preventing graft rejection
10. Fas ligand-induced apoptosis as a mechanism of immune privilege
11. Cotransplantation of allogeneic islets with allogeneic testicular aggregates allows long-term graft survival without systemic immunosuppression
12. Prevention of allograft rejection with engineered myoblasts expressing FasL in mice
13. Fas Ligand gene transfer to renal allografts in rats, effects on allograft survival
14. Down-regulation of human alloimmune responses by genetically engineered expression of CD95 ligand on stimulatory and target cells
15. Transgeneic expression of CD95 ligand on islet β cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts
16. Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction
17. Accelerated rejection of Fas ligand-expressing heart grafts
18. Soluble Fas ligand is chemotactic for human neutrophilic polymorphonuclear leukocytes
19. Regulation of the proinflammatory effects of Fas ligand
20. Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance