Upregulation of intraepithelial lymphocyte (IEL) function in the small intestinal mucosa in sepsis

Shock

Volumn 16, Issue 6, 2001, Pages 454-458

  Nüssler, Natascha C ^a   Stange, Barbara ^a   Nussler, Andreas K ^a   Settmacher, Utz ^a   Langrehr, Jan M ^a   Neuhaus, Peter ^a   Hoffman, Rosemary A ^b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

LPS; Mucosal lymphocytes; Nitric oxide; Small intestine

Indexed keywords

GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE SYNTHASE;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL DIVISION; CYTOTOXICITY; DRUG EFFECT; ENDOTOXEMIA; FEMALE; GENETICS; IMMUNOLOGY; IN VITRO STUDY; INTESTINE MUCOSA; LYMPHOCYTE; LYMPHOCYTE SUBPOPULATION; METABOLISM; MOUSE; MOUSE STRAIN; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SEPSIS; SMALL INTESTINE;

ANIMAL; CELL DIVISION; CYTOTOXICITY, IMMUNOLOGIC; ENDOTOXEMIA; FEMALE; IN VITRO; INTERFERON TYPE II; INTESTINAL MUCOSA; INTESTINE, SMALL; LIPOPOLYSACCHARIDES; LYMPHOCYTE SUBSETS; LYMPHOCYTES; MICE; MICE, INBRED C57BL; NITRIC-OXIDE SYNTHASE; RNA, MESSENGER; SEPSIS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0035653723     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-200116060-00009     Document Type: Article

References (33)

1. Berg RD, Garlington AW: Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model. Infect Immun 23:403-411, 1979.
2. Yoshikai Y: The interaction of intestinal epithelial cells and intraepithelial lymphocytes in host defense. Immunol Res 20:219-235, 1999.
3. James SP: The gastrointestinal mucosal immune system. Dig Dis 11:146-156, 1993.
4. Yanamoto S, Russ F, Teixeira HC, Conradt P, Kaufmann SHE: Listeria monocytogenes-induced gamma interferon secretion by intestinal intraepithelial γ/δ T lymphocytes. Infect Immun 61:2154-2161, 1993.
5. Gautreaux MD, Deitch EA, Berg RD: T lymphocytes in host defense against bacterial translocation from the gastrointestinal tract. Infection Immun 62:2874-2884, 1994.
6. Lefrancois L: Phenotypic complexity of intraepithelial lymphocytes of the small intestine. J Immunol 147:1746-1751, 1991.
7. + intraepithelial lymphocytes. Nature 333:855-858, 1988.
8. Gramzinski RA, Adams E, Gross JA, Goodman TG, Allison JP, Lefrancois L: T cell receptor-triggered activation of intraepithelial lymphocytes in vitro. Int Immunol 5:145-153, 1993.
9. Ishikawa H, Li Y, Abeliovich A, Yanamoto S, Kaufmann HSE, Tonegawa S: Cytotoxic and interferon γ-producing activities of γδ T cells in the mouse small intestinal epithelium are strain dependent. Proc Natl Acad Sci USA 90:8204-8208, 1993.
10. Born W, Hall L, Dallas A, Boymel J, Shinnick T, Yound D, Brennan P, O'Brien R: Recognition of a peptide antigen by heat shock reactive γδ T lymphocytes. Science 249:67-69, 1990.
11. Sydora BC, Jamieson BD, Ahmed R, Kronenberg M: Intestinal intraepithelial lymphocytes respond to systemic lymphocytic choriomeningitis virus infection. Cell Immunol 167:161-169, 1996.
12. Barrett TA, Gajewski TF, Danielpour D, Chang EB, Beagley KW, Bluestone JA: Differential function of intestinal intraepithelial lymphocyte subsets. J Immunol 149:1124-1130, 1992.
13. 1 phase of cell cycle produce IFN-γ and IL-5. J Immunol 150:106-114, 1993.
14. Madara JL, Stafford J: Interferon-γ directly affects barrier function of cultured intestinal epithelial monolayers. J Clin Invest 83:724-727, 1989.
15. Taylor CT, Murphy A, Kelleher D, Baird AW: Changes in barrier function of a model intestinal epithelium by intraepithelial lymphocytes require new protein synthesis by epithelial cells. Gut 40:634-640, 1997.
16. Dignass AU, Sturm A, Becker A, Hotz A, Goebell H: Interferon-γ modulates intestinal epithelial cell function in vitro through a TGFβ-dependent mechanism. Z Gastroenterol (Suppl 1):50-57, 1998.
17. Hoffman RA, Zhang G, Nüssler NC, Gleixner SL, Ford HR, Simmons RL, Watkins SC: Constitutive expression of inducible nitric oxide synthase in the mouse ileal mucosa. Am J Physiol 272:G383-G392, 1997.
18. ++-independent nitric oxide synthases. FEBS Lett 291:145-149, 1991.
19. Wolkow PP: Involvement and dual effects of nitric oxide in septic shock. Inflamm res 47:152-166, 1998.
20. Leon LR, Kozak W, Rudolph K, Kluger MJ: An antipyretic role for interleukin-10 in LPS fever in mice. Am J Physiol 276:R81-R89, 1999.
21. Galanos C, Freudenberg MA, Reutter W: Galactosamine-induced sensitization to the lethal effects of endotoxin. Proc Natl Acad Sci USA 76:5939-5943, 1979.
22. Nüssler NC, Hoffman RA, McCarthy SA, Simmons RL: Functional changes of intestinal intraepithelial lymphocytes during acute graft-versus host disease: correlation with phenotype. Int Immunol 8:1767-1777, 1996.
23. Hoffman RA: Intraepithelial lymphocytes coinduce nitric oxide synthase in intestinal epithelial cells. Am J Physiol 278:G886-G894, 2000.
24. Bone RC: Gram-negative sepsis: A dilemma of modern medicine [review] Clin Microbiol Rev 6:57-68, 1993.
25. Deitch EA, Berg R, Specian R: Endotoxin promotes the translocation of bacteria from the gut. Arch Surg 122:185-190, 1987.
26. Sydora BC, Mixter PF, Holcombe HR, Eghtesady P, Williams K, Amaral MC, Nel A, Kronenberg M: Intestinal intraepithelial lymphocytes are activated and cytolytic but do not proliferate as well as other T cells in response to mitogenic signals. J Immunol 150:2179-2191, 1993.
27. Viney JL, MacDonald TT: Lymphokine secretion and proliferation of intraepithelial lymphocytes from murine small intestine. Immunology 77:19-24, 1992.
28. Österberg J, Johnsson C, Gannedahl G, Westlund A, Haglund U: Alterations in mucosal immune cell distribution in septic rats. Shock 7:182-185, 1997.
29. Nüssler NC, Stange B, Hoffman RA, Schraut WH, Bauer AJ, Neuhaus P: Enhanced cytolytic activity of intestinal lymphocytes in patients with Crohn's disease. Langenbeck's Arch Surg 385:218-224, 2000.
30. Nüssler NC, O'Brien J, Stange B, Platz K-P, Neuhaus P, Mμller AR: IL-2 promotes the subset restoration of intraepithelial lymphocytes after ischemia/reperfusion injury. Transplant Proc 32:1305-1306, 2000.
31. Peters M: Action of cytokines on the immune response and viral interactions: an overview. Hepatology 23:909-916, 1996.
32. Gennari R, Alexander W, Eaves-Pyles T: IFN-γ decreases translocation and improves survival follwing transfusion and thermal injury. J Surg Res 56:530-536, 1994.
33. Gregory SH, Wing EJ, Hoffman RA, Simmons RL: Reactive nitrogen intermediates suppress the primary immunologic response to Listeria. J Immunol 150:2901-2909, 1993.