The interaction of intestinal epithelial cells and intraepithelial lymphocytes in host defense

Immunologic Research

Volumn 20, Issue 2, 1999, Pages 219-235

  Yoshikai, Yasunobu ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

CD4+; CD8+i IEL; Fas Fas L; IL 15; Listeria monocytogenes; MHC class I

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; FAS LIGAND; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTEGRIN; INTERLEUKIN 15; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; T LYMPHOCYTE RECEPTOR; UVOMORULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; BACTERIAL INFECTION; BINDING SITE; CELL ACTIVATION; CELL INTERACTION; CONTROLLED STUDY; HOMEOSTASIS; HOST RESISTANCE; HUMAN; INTESTINE EPITHELIUM CELL; INTESTINE INFECTION; LISTERIA MONOCYTOGENES; LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; REVIEW; T LYMPHOCYTE; TH1 CELL;

EID: 0033508882     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02790405     Document Type: Review

References (102)

1. + intraepithelial lymphocytes. Nature 1988;333: 855-858.
2. 2 Bonneville M, Janeway CA, Ito K, Haser W, Ishida I, Nakanishi N, Tonegawa S: Intestinal intraepithelial lymphocytes are a distinct set of γδ T cells. Nature 1988; 336:479-481.
3. 3 Klein JR: Advances in intestinal T-cell development and function. Immunol Today 1995;16:322-324.
4. + and are thymus dependent. Eur J Immunol 1990;20:1193-1196.
5. - lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood. Eur J Immunol 1990;20:1097-1103.
6. 6 Van Kerckhove C, Russel GJ, Deusch K, Reich K, Bhan AK, DerSimonian H, Brenner MB: Oligoclonality of human intestinal intraepithelial T cells. J Exp Med 1992;175:57-63.
7. - cells and high expression of the RT6 alloantigen. Eur J Immunol 1991; 21:753-760.
8. + intestinal intraepithelial lymphocytes in rats. Eur J Immunol 1992; 22:159-164.
9. 9 Rocha B, Vassalli P, Guy-Grand D: Thymic and extrathymic origins of gut intraepitherial lymphocyte populations in mice. J Exp Med 1994;180:681-686.
10. 10 Lefrançois L, Puddington L: Extrathymic intestinal T-cell development: virtual reality? Immunol Today 1995;16:16-21.
11. 11 Takeuchi M, Miyazaki H, Mirokawa K, Yokokura T, Yoshikai Y: Age-related changes of T cell subsets in intestinal intraepithelial lymphocytes of mice. Eur J Immunol 1993;23:1409-1411.
12. + murine intestinal intraepithelial lymphocyte. Int Immunol 1990;2:361-365.
13. + intestinal intraepithelial lymphocyte specific for DnaK (Escherichia coli HSP70) may be selected by intestinal microflora of rats. Immunobiology 1996-1997;196:550-566.
14. +T-cell clones. Nature 1988; 335:642-644.
15. + T cells: Induction is inhibited by rat recombinant interleukin 4. J Exp Med 1992;176:1551-1559.
16. + T cells migrating into the murine small intestine epithelial layer. Eur J Immunol 1995; 25:1580-1588.
17. 17 Balk SP, Ebert EC, Blumenthal RL, McDermott FV, Wucherpfennig KW, Landau SB, Blumberg RS: Oligoclonal expansion and CD1 recognition by human intestinal intraepithelial lymphocytes. Science 1991;253:1411-1415.
18. 18 Regnault A, Cumano A, Vassalli P, Guy-Grand D, Kourilsky, P: Oligoclonal repertoire of the CD8αα and the CD8αβ TCR-α/β murine intestinal intraepithelial T lymphocytes: evidence for the random emergence of T cells. J Exp Med 1994;180:1345-1358.
19. + lymphocytes reveals a major extrathymic pathway of T cell differentiation. J Exp Med 1991;173:483-486.
20. 20 Murosaki S, Yoshikai Y, Ishida A, Nakamura T, Matsuzaki G, Takimoto H, Yuuki H, Nomoto K: Failure of T cell receptor Vβ negative selection in murine intestinal intra-epithelial lymphocytes. Int Immunol 1991;3: 1005-1013.
21. 21 Regnault A, Levraud JP, Lim A, Moreau C, Cumano A, Kourilsky P: The expansion and selection of T cell receptor αβ intestinal intraepithelial T cell clones. Eur J Immunol 1996;26:914-915.
22. 22 Beagley KW, Fujihashi K, Black CA, Lagoo AS, Yamamoto M, McGhee JR, Kiyono H: The my-cobacterium tuberculosis 71kDa heat-shock protein induces proliferation and cytokine secretion by murine gut intraepithelial lymphocytes. Eur J Immunol 1993;23: 2049-2052.
23. 23 Blumberg RS, Balk SP: Intraepithelial lymphocytes and their recognition of non-classical MHC molecules. Int Rev Immunol 1994; 11:15-30.
24. 24 Nakamura T, Matsuzaki G, Takimoto H, Nomoto K: Age-associated changes in the proliferative response of rat intestinal intraepithelial leukocytes to bacterial antigens. Gastroenterology 1995; 109:748-754.
25. + intestinal intraepithelial lymphocytes. J Immunol 1996;156:4209-4216.
26. 26 Guy-Grand D, Cuenod-Jabri B, Malassis-Seris M, Selz F, Vassalli P: Complexity of the mouse gut T cell immune system: identification of two distinct natural killer T cell intraepithelial lineages. Eur J Immunol 1996;26:2248-2256.
27. 27 Sakai T, Kimuru Y, Inagaki-Ohara K, Kusugami K, Lynch DH, Yoshikai Y: Fas-mediated cytotoxicity by intestinal intraepithelial lymphocytes during acute graft-versus-host disease in mice. Gastroenterology 1997;113:168-174.
28. 28 Inagaki-Ohara K, Nishimura H, Inagaki H, Sakai T, Takano M, Lynch DH, Yoshikai Y: Involvement of fas antigen/fas ligand interaction in apoptosis of epithelial cells by intraepithelial lymphocytes in murine small intestine. Lab Invest 1997;77:421-429.
29. + T cells provide B cell help. J Exp Med 1992;175: 695-707.
30. 30 Komano H, Fujiura Y, Kawaguchi M, Matsumoto S, Hashimoto Y, Obana S, Mombaerts P, Tonegawa S, Yamamoto H, Itohara S, Nanno M, Ishikawa H: Homeostatic regulation of intestinal epithelia by intraepithelial γδ T cells. Proc Natl Acad Sci USA 1995;92:6147-6151.
31. 31 Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL: Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986;136:2348-2357.
32. + T lymphocytes. Immuno Today 1988;9:268-274.
33. 33 Mosmann TR, Coffman RL: Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-173.
34. + T-cell subsets in vivo. Immunol Rev 1991;123:189-207.
35. 35 Kopf M, Le Gros G, Bachmann M, Lamers MC, Bluethmann H, Kohler G: Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 1993; 362:245-248.
36. 36 Chen Y, Inobe J, Marks R, Gonnella P, Kuchroo VK, Weiner HL: Peripheral depletion of antigen-reactive T cell in oral tolerance. Nature 1995;376:177-180.
37. 37 Fukaura H, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL, Hafler DA: Induction of circulating myelin basic protein and proteo-lipid protein-specific transforming growth factor-β1-secreting Th3 cells by oral administration of myelin in multiple sclerosis patients. J Clin Invest 1996;98:70-77.
38. + T cells for helper activity. Int Immunol 1993;5:1473-1481.
39. + T cells, but not natural killer cells. J Exp Med 1996;184:289-293.
40. 40 Maki K, Sunaga S, Komagata Y, Kodaira Y, Mabuchi A, Karasuyama H, Yokomuro K, Miyazaki J, Ikuta K: Interleukin 7 receptor-deficient mice lack γδT cells. Proc Natl Acad Sci USA 1996;93: 7172-7177.
41. 41 Puddington L, Olson S, Lefrançois L: Interactions between stem cell factor and c-Kit are required for intestinal immune system homeostasis. Immunity 1994;1:733-739.
42. 42 Inagaki-Ohara K, Nishimura H, Mitani A, Yoshikai Y: Interleukin-15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing γδ T cell receptor in mice. Eur J Immunol 1997;27:2885-2891.
43. 43 Giri JG, Ahdieh M, Eisenman J, Shanebeck K, Grabstein KH, Kumaki S, Namen A, Park LS, Cosman D, Anderson D: Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J 1994;13:2822-2830.
44. 44 Armitage RJ, Macduff BM, Eisenman J, Paxton R, Grabstein KH: IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. J Immunol 1995;154:483-490.
45. 45 Carson WE, Giri JG, Lindemann MJ, Linett ML, Ahdieh M, Paxton R, Anderson D, Eisenmann J, Grabstein K, Caligiuri MA: Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J Exp Med 1994;180: 1395-1403.
46. 46 Nishimura H, Hiromatsu K, Kobayashi N, Grabstein KH, Paxton R, Sugamura K, Bluestone J A, Yoshikai Y: IL-15 is a novel growth factor for murine γδ T cells induced by Salmonella infection. J Immunol 1996;156:663-669.
47. 47 Grabstein KH, Eisenman J, Shanebeck K, Rauch C, Srinivasan S, Fung V, Beers C, Richardson J, Schoenborn MA, Ahdieh M, Johnson L, Alderson MR, Watson JD, Anderson DM, Giri JG: Utilization of the β and γ chains of a T cell growth factor that interacts with the β chain of the interleukin-2 receptor. Science 1994;264:965-967.
48. 48 Ellis RE, Yuan J, Horvitz HR: Mechanosms and functions of cells death. Annu Rev Cell Biol 1991; 7:663-698
49. 49 Walker NI, Harmon BV, Gobe GC, Kerr J FR: Patterns of cell death. Methods Achiev Exp Pathol 1988; 13:18-54.
50. 50 Iwanaga T, Hoshi O, Han H, Takahashi-Iwanaga H, Uchiyama Y, Fujita T. Lamina propria macrophages involved in cell death(apoptosis) of enterocytes in the small intestine of rats. Arch Histol Cytol. 1994;57:267-276.
51. 51 Pottem CS, Loeffler M: Stem cells: attributes, cycles, spirals, pitfalls, and uncertainties: Lessons for and from the crypt. Development 1990; 110:1001-1020.
52. + lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation. J Exp Med 1991;173:471-481.
53. 53 Lefrançois L: Phenotypic complexity of intraepithelial lymphocytes of the small intestine. J Immunol 1991;147:1746-1750.
54. 54 Barrett TA, Gajewski TF, Danielpour D, Chang EB, Beagley KW, Bluestone JA. Differential function of intestinal intraepithelial lymphocyte subsets. J Immunol 1992;149:1124-1130.
55. 55 Guy-Grand D, Malassis-Seris M, Briottet C, Vassalli P. Cytotoxic differentiation of mouse gut thymodependent and independent intraepithelial T lymphocytes is induced locally. Correlation between functional assays, presence of perforin and granzyme transcripts, and cytoplasmic granules. J Exp Med 1991;173:1549-1552.
56. 56 Itoh N, Yonehara S, Ishii, Yonehara M, Mizushima SI, Sameshima M, Hase A, Seto Y, Nagata S: The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 1991;66:233-243.
57. 57 Oehm A, Behrmann I, Falk W, Pawlita M, Maier G, Klas C, Li-Weker M, Richards S, Dhein J, Trauth BC, Ponstingl H, Krammer PH: Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily: sequence identity with the Fas antigen. J Biol Chem 1992;267: 10709-10715.
58. 58 Watanabe-Fukunaga R, Brannan IC, Itoh N, Yonehara S, Copeland GN, Jenkins AN, Nagata S: The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. J Immunol 1992;148:1274-1279.
59. 59 Suda T, Takahashi T, Golstein P, Nagata S: Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 1993; 75:1169-1178.
60. + thymocyte population associated with intact Fas antigen expression on the target. J Exp Med 1994;180:423-432.
61. 61 Suda T, Okazaki T, Naito Y, Yokota T, Arai N, Ozaki S, Nakao K, Nagata S: Expression of the Fas ligand in cells of T cell lineage. J Immunol 1995;154:3806-3813.
62. 62 Ramsdell F, Seaman MS, Miller RE, Picha KS, Kennedy MK, Lynch DH: Differential ability of Th1 and Th2 T cells to express Fas ligand and to undergo activation-induced cell death. Int Immnuol 1994;6:1545-1553.
63. 63 Cerf-Bensussan, Quaroni NA, Kurnick JT, Bhan AK: Intraepithelial lymphocytes modulate la expression by intestinal epithelial cells. J Immunol 1984; 132:2244-2249.
64. +, granulated subpopulation to natural killer cells and mast cells. Eur J Immunol 1985; 15:211-215.
65. 65 Brunner T, Mogil JR, LaFace D, Yoo JN, Mahboubi A, Echeverri F, Martin JS, Force RW, Lynch HD, Ware FC, Green RD: Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 1995;373: 441-444.
66. 66 Ju TS, Panka JD, Cui H, Ettinger R, El-Khatib M, Sherr HD, Stanger ZB, Marshak-Rothstein A: Fas(CD95)/Fas L interactions required for programmed cell death after T-cell activation. Nature 1995; 373:444-448.
67. 67 Dhein J, Walczak H, Bäumler C, Debatin KM, Krammer PH: Autocrine T-cell suicide mediated by APO-1(Fas/CD95). Nature 1995; 373:438-441.
68. 68 Bamford RN, Grant AJ, Burton JD, Peters C, Kurys G, Goldman CK, Brennan J, Roessler E, Waldmann TA: The interleukin (IL) 2 receptor β chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc Nat Acad Sci USA 1994;91:4940-4944.
69. 69 Washizu J, Nishimura H, Nakamura Y, Yoshikai Y: The NF-κB binding sites is essential for transcriptional activation of the IL-15 gene. Immunogenetics 1998;48:1-7
70. 70 Nishimura H, Washizu J, Nakamura N, Enomoto A, Yoshikai Y: Translational efficiency is up-regulated by alternative exon in murine IL-15 mRNA. J Immunol 1998;160:936-942.
71. 71 Reinecker HC, MacDermott RP, Mirau S, Dignass A, Podolsky DK: Intestinal epithelial cells both express and respond to interleukin 15. Gastroenterology 1996;111: 1706-1713.
72. 72 Doherty TM, Seder RA, Sher A: Induction and regulation of IL-15 expression in murine macrophages. J Immunol 1996;156:735-741.
73. 73 Jullien D, Sieling PA, Uyemura K, Mar ND, Rea TH, Modlin RL: IL-15, an immunomodulator of T cell responses in intracellular infection. J Immunol 1997;158:800-806.
74. 74 Chehimi J, Marshall JD, Salvucci O, Frank I, Chehimi S, Kawecki S, Bacheller D, Rifat S, Chouaib S: IL-15 enhances immune functions during HIV infection. J Immunol 1997;158:5978-5987.
75. + T cell-mediated immunity against Toxoplasma gondii infection in mice. J Immunol 1996;157:2103-2108.
76. 76 Kakumu S, Okumura A, Ishikawa T, Yano M, Enomoto A, Nishimura H, Yoshioka K, Yoshikai Y: Serum levels of IL-10, IL-15 and soluble tumour necrosis factor-alpha (TNF-alpha) receptors in type C chronic liver disease. Clin Exp Immunol 1997;109:458-463.
77. 77 Yamamoto S, Russ F, Teixeira HC, Conradt P, Kaufmann SH: Listeria monocytogenes-induced gamma interferon secretion by intestinal intraepithelial gamma/delta T lymphocytes. Infect Immun 1993;61: 2154-2161.
78. 78 Yamamoto M, Fujihashi K, Beagley KW, McGhee JR, Kiyono H: Cyokine synthesis by intestinal intraepithelial lymphocytes. J Immunol 1993;150:106-114.
79. 79 Baeuerle PA, Henkel T: Function and activation of NF-κB in ths immune system. Annu Rev Immunol 1994;12:141-179.
80. 80 Naumann M, Wessler S, Bartsch C, Wieland B, Meyer TF: Neisseria gonorrhoeae epithelial cell interaction leads to the activation of the transcription factors nuclear factor kappaB and activator protein I and the induction of inflammatory cytokines. J Exp Med 1997;186: 247-258.
81. 81 Mengaud J, Ohayon H, Gounon P, Mege RM, Cossart P: E-cadherin is the receptor for internalin, a surface protein required for entry of L.monocytogenes into epithelial cells. Cell 1996;84:923-932.
82. 82 Boller K, Vestweber D, Kemler R: Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells. J Cell Biol 1985; 100:327-332.
83. 83 Cepek KL, Shaw SK, Parker CM, Russell GJ, Morrow JS, Rimm DL, Brenner MB: Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin. Nature 1994;372:190-193.
84. 84 Hermiston ML, Gordon JI: In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death. J Cell Biol 1995;129:489-506.
85. 85 Kirkpatrick C, Peifer M: Not just glue: cell-cell junctions as cellular signaling centers. Curr Opin Genet Dev 1995;5:56-65.
86. 86 Mason I: Cell signaling. Do adhesion molecules signal via FGF receptors? Curr Biol 1994;4:1158-1161.
87. 87 Carson WE, Ross ME, Baiocchi RA, Marien MJ, Boiani N, Grabstein K, Caligiuri MA: Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro. J Clin Invest 1995;96: 2578-2582.
88. + cell development. J Immunol 1997;159:5931-5935.
89. 89 Warren HS, Kinnear BF, Kastelein RL, Lanier LL: Analysis of the costimulalory role of IL-2 and IL-15 in initiating proliferation of resting (CD56dim) human NK cells. J Immunol 1996;156: 3254-3259.
90. 90 Voss SD, Sondel PM, Robb RJ: Characterization of the interleukin 2 receptors (IL-2R) expressed on human natural killer cells activated in vivo by IL-2: association of the p64 IL-2R gamma chain with the IL-2R beta chain in functional intermediate-affinity IL-2R. J Exp Med 1992;176:531-541.
91. 91 DiSanto JP, Muller W, Guy-Grand D, Fischer A, Rajewsky K: Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc Natl Acad Sci USA 1995;92:377-381.
92. 92 Suzuki H, Duncan GS, Takimoto H, Mak TW: Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor β chain. J Exp Med 1997;185:499-505.
93. 93 Tanaka T, Kitamura F, Nagasaka Y, Kuida K, Suwa H, Miyasaka M: Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor beta chain monoclonal antibody in mice. J Exp Med 1993; 178: 1103-1107.
94. 94 Lodolce JP, Boone DL, Chai S, Swain RE, Dassopoulos T, Trettin S, Ma AIL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 1998; 9:669-676.
95. 95 Hiromatsu K, Yoshikai Y, Matsuzaki G, Ohga S, Muramori K, Matsumoto K, Bluestone JA, Nomoto K: A protective role of 65-kDa heat shock protein-specific γδ T cells in primary infection with Listeria monocytogenes in mice. J Exp Med 1992;175:49-56.
96. 96 Kaufmann SHE, Emoto M, Szalay G, Barsig J, Flesch IEA: Interleukin-4 and listeriosis. Immunol Rev 1997;158:95-105.
97. 97 North RJ, Dunn PL, Conlan JW: Murine listeriosis as a model of antimicrobial defense. Immunol Rev 1997;158:27-36.
98. + intestinal intraepithelial lymphocytes in rats. Int Imunol 1999;11:21-28.
99. 99 Hirose K, Suzuki H, Nishimura H, Mitani A, Washizu J, Matsuguchi T, Yoshikai Y: Interleukin-15 might be responsible early activation of intestinal intraepithelial lymphocytes after oral infection with Listeria monocytogenes in rats. Infect Immun 1998;66:5677-5683.
100. 100 Mitani A, Nishimura H, Hirose K, Washizu J, Kimura Y, Tanaka S, Noguchi T, Yoshikai Y: Interleukin-15 might be responsible for early activation of intestinal intraepithelial lymphocytes after oral infection with Listeria monocytogenes in mice. Immunolgy in press. 1999.
101. 101 Hirose K, Nishimura H, Matsuguchi T, Yoshikai Y: Endogenous IL-15 might be responsible for early protection by natural killer cells against infection with avirulent strain of Salmonella choleraesuis in mice. J Leukocyte Biol in press, 1999.
102. 102 Kimura K, Nishimura H, Kirose K, Matsuguchi T, Nimura Y, Yoshikai Y: Immunogene therapy for murine fibrosarcoma using IL-15 gene with high translation efficiency. Eur J Immunol in press 1999.