The Effects of Active Ingredients of Standard Debriding Agents - Papain and Collagenase - On Digestion of Native and Denatured Collagenous Substrates, Fibrin and Elastin

Wounds

Volumn 13, Issue 5, 2001, Pages 190-194

  Hebda, Patricia A ^a   Lo, Chia Yee ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0035642917     PISSN: 10447946     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Durham DR. The unique stability of Vibrio proteolyticus neutral protease under alkaline conditions affords a selective step for purification and use in amino acid-coupling reactions. Appl Environ Microbiol 1990;56:2277-81.
2. Durham DR, Fortney DZ, Nanney LB. Preliminary evaluation of Vibriolysin, a novel proteolytic enzyme composition suitable for the debridement of burn wound eschar. J Burn Care Rehabil 1993;14:544-51.
3. Mekkes JR, LePoole IC, Das PK, Kammeyer A, Westerhof W. In vitro tissue-digesting properties of krill enzymes compared with fibrinolysin/DNase, papain and placebo. Int J Biochem Cell Biol 1997;29:703-6.
4. Skrabut EM, Hebda PA, Samuels JA, et al. Removal of necrotic tissue with an Ananain-based enzyme debriding preparation. Wound Rep Regen 1996;4:433-13.
5. Hobson D, White E, Anderson L, Lira L. Development and use of a quantitative method to evaluate the action of enzymatic wound debriding agents in vitro. WOUNDS 1998;10(4):105-10.
6. Mandel I, MacLeman JD, Howes EL, DeBellis RH, Sohler A. Isolation and characterization of proteinase and collagenase from Clostridium histolyticum. J Clin Invest 1953;32:1323-9.
7. Hebda PA, Flynn KJ, Dohar JE. Evaluation of the efficacy of enzymatic debriding agents for the removal of necrotic tissue and promotion of healing in porcine skin wounds. WOUNDS 1998;10(3):83-96.