Reorientational dynamics, hydrogen bonding and hydrophilicity of X-ray contrast agents in solution

Magnetic Resonance in Chemistry

Volumn 39, Issue SPEC. ISS., 2001, Pages

  Van De Bruck, Michael ^a   Dölle, Andreas ^a   Michl, Günter ^b   Radüchel, Bernd ^b  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b BAYER PHARMA AG   (Germany)

Author keywords

13C; Hydrogen bonds; Hydrophilicity; Lipophilicity; NMR; Partition coefficients; Structure activity relationships; X ray contrast agents

Indexed keywords

HYDROPHILICITY; NUCLEAR MAGNETIC RESONANCE;

13C; CONTRAST AGENT; CORRELATION TIME; IOHEXOL; IOPAMIDOL; LIPOPHILICITY; MOLECULAR CORRELATIONS; PARTITION COEFFICIENT; STRUCTURE-ACTIVITY RELATIONSHIPS; X-RAY CONTRAST AGENTS;

HYDROGEN BONDS;

EID: 0035604874     PISSN: 07491581     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrc.936     Document Type: Article

References (18)

1. Silvermann RB. The Organic Chemistry of Drug Design and Drug Action. Academic Press: 1992.
2. Kubinyi H. In Methods and Principles in Medicinal Chemistry, vol. 1, Mannhold R, Kroogsgaard-Larsen P, Timmermann H (eds). VCH: Weinheim, 1993.
3. Tute MS. In Comprehensive Medicinal Chemistry, vol. 4, Hansch C, Sammes PG, Taylor JB (eds). Pergamon Press: Oxford, 1990; 1.
4. Bowden K. In Comprehensive Medicinal Chemistry, vol. 4, Hansch C, Sammes PG, Taylor JB (eds). Pergamon Press: Oxford, 1990; 205.
5. Taylor PJ. In Comprehensive Medicinal Chemistry, vol. 4, Hansch C, Sammes PG, Taylor JB (eds). Pergamon Press: Oxford, 1990; 241.
6. Radiocontrast Agents. In Handbook of Experimental Pharmacology, vol. 73, Sovak M (ed.). Springer-Verlag: Berlin, 1984.
7. Bonnemain B, Meyer D, Schaefer M, Dugast-Zrihen M, Legreneur S, Doucet D. Invest. Radiol. 1990; 25: S104.
8. Violon D. Invest. Radiol. 1996; 31: 569.
9. Gruhlke P, Seipelt CG, Dölle A, Zeidler MD, Zaderenko P, Ballesteros P, Cerdan S. J. Chem. Soc., Perkin Trans. 2 1995; 2191.
10. Lyerla JR, Levy GC. Top. Carbon-13 NMR Spectrosc. 1972; 1: 79.
11. Kluner RP, Dölle A. J. Phys. Chem. A 1997; 101: 1657.
12. Reichardt C. Solvents and Solvent Effects in Organic Chemistry. VCH: Weinheim, 1990.
13. Uedaira H, Ishimura M, Tsuda S, Uedaira H. Bull. Chem. Soc. Jpn. 1990; 63: 3376.
14. Bagno A, Lovato G, Scorrano G, Wijnen JW. J. Phys. Chem. 1993; 97: 4601.
15. Ishihara Y, Okouchi S, Uedaira H. J. Chem. Soc., Faraday Trans. 1997; 93: 3337.
16. Perrin CL, Gipe RK. J. Am. Chem. Soc. 1986; 108: 1088.
17. Dewar MJ, Zoebisch EG, Healy EF, Stewart JJP. J. Am. Chem. Soc. 1985; 107: 3902.
18. HyperChem Version 5. Hypercube, Inc.: Waterloo, 1996.