Correlation of some geometric parameters derived from molecular models of monomer nonionic contrast medium molecules with their octanol/water partition coefficient

Investigative Radiology

Volumn 31, Issue 9, 1996, Pages 569-576

  Violon, Daniel ^a,b  

^a Stuivenberg General Hospital   (Belgium)

^b NONE   (Belgium)

Author keywords

Contrast media

Indexed keywords

BENZENE DERIVATIVE; IOHEXOL; IOPAMIDOL; IOPROMIDE; IOVERSOL; MONOMERIC NONIONIC CONTRAST MEDIUM; OCTANOL; WATER;

ARTICLE; CHIRALITY; CORRELATION FUNCTION; DRUG DESIGN; GEOMETRY; HYDROPHILICITY; MOLECULAR MODEL; PARTITION COEFFICIENT; PRIORITY JOURNAL;

EID: 0029758827     PISSN: 00209996     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004424-199609000-00005     Document Type: Article

References (10)

1. Katayama H, Yamaguchi K, Kozuka T, Takashima T, Seez P, Matuura K. Adverse reactions to ionic and nonionic contrast media: A report from the Japanese Committee on the Safety of Contrast Media. Radiology 1990;175:621-628.
2. Bonnemain B, Meyer D, Schaefer M, Dugast-Zrihen M, Legreneur S, Doucet D. New iodinated, low-osmolar contrast media: A revised concept of hydrophilicity. Invest Radiol 1990;25:S104-S106.
3. Mezey PG. Shape in chemistry. New York, NY: VCH Publishers, Inc., 1993.
4. Iman RL. A data-based approach to statistics. Belmont, CA: Duxbury Press, Wadsworth Publishing Company, 1994.
5. Lang JH, Lasser EC. Nonspecific inhibition of enzymes by organic contrast media. J Med Chem 1971;14:233-236.
6. Rapoport ST, Levitan H. Neurotoxicity of x-ray contrast media: Relation to lipid solubility and blood-brain barrier permeability. AJR Am J Roentgenol 1974;122:186-193.
7. Sovak M, Ranganathan R, Lang JH, Lasser EC. Concepts in design of improved intravascular contrast agents. Ann Radiol 1978;21(4-5):283-289.
8. Almen T. Relations between chemical structure, animal toxicity, and clinical adverse effects of contrast media. In: Enge I, Edgren J, eds. Patient safety and adverse events in contrast medium examinations. Amsterdam, The Netherlands: Elsevier Science Publishers, 1989.
9. Rekker RF, Mannhold R. Calculation of drug lipophilicity: The hydrophobic fragmental constant approach. Weinheim: VCH Publishers, Inc., 1992.
10. Pitre D, Felder E. Development, chemistry, and physical properties of iopamidol and its analogues. Invest Radiol 1980;15: S301-S309.