Computational 3-D modeling and site-directed mutation of an antibody that binds Neu2en5Ac, a transition state analogue of a sialic acid

Proteins: Structure, Function and Genetics

Volumn 45, Issue 4, 2001, Pages 285-296

  Kamei, Hiroya ^a   Shimazaki, Kazuko ^a   Nishi, Yoshisuke ^a  

^a JAPAN TOBACCO INC   (Japan)

Author keywords

Affinity docking; Catalytic antibody; Cys; Phage display; ScFv; Sialidase; VH CDR3

Indexed keywords

5 ACETAMIDO 2,6 ANHYDRO 3,5 DIDEOXY DEXTRO GLYCERO DEXTRO GALACTONON 2 ENONIC ACID; ACETAMIDE DERIVATIVE; CARBOXYL GROUP; SIALIC ACID DERIVATIVE; SIALIDASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; ENZYME ACTIVE SITE; ENZYME MECHANISM; GENETIC CONSERVATION; MOLECULAR MODEL; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; ANTIBODIES; ANTIBODIES, CATALYTIC; BASE SEQUENCE; EPITOPES; IMMUNOGLOBULIN VARIABLE REGION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; N-ACETYLNEURAMINIC ACID; NEURAMINIDASE; SEQUENCE ANALYSIS, DNA;

EID: 0035576131     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.1149     Document Type: Article

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