Repeated imipramine adminstration ehnances the effects of NMDA receptor ligands on synchromous activity in rat frontal cortex in vitro

Polish Journal of Pharmacology

Volumn 53, Issue 6, 2001, Pages 635-639

  Bobula, Bartosz ^a   Tokarski, Krysztof ^a   Hess, Grzegorz ^a  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

Antidepressant drug; Epileptiform activity; Neocortical slice; Rat

Indexed keywords

2 AMINO 4 METHYL 5 PHOSPHONO 3 PENTENOIC ACID; ANTIDEPRESSANT AGENT; IMIPRAMINE; LIGAND; MAGNESIUM ION; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; 2 AMINO 5 PHOSPHONOVALERIC ACID; 2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID; AMINO ACID RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR STIMULATING AGENT; DRUG DERIVATIVE; N METHYLASPARTIC ACID; TRICYCLIC ANTIDEPRESSANT AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN SLICE; COMPETITIVE INHIBITION; CONTROLLED STUDY; CORTICAL SYNCHRONIZATION; DRUG EFFECT; DRUG MECHANISM; EPILEPTIC DISCHARGE; FRONTAL CORTEX; IN VITRO STUDY; INCUBATION TIME; MALE; NONHUMAN; RAT; ANIMAL; FRONTAL LOBE; METABOLISM; NERVE CELL; NERVE CELL PLASTICITY; PHYSIOLOGY; SYNAPTIC TRANSMISSION; WISTAR RAT;

2-AMINO-5-PHOSPHONOVALERATE; ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; CORTICAL SYNCHRONIZATION; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; FRONTAL LOBE; IMIPRAMINE; LIGANDS; MALE; N-METHYLASPARTATE; NEURONAL PLASTICITY; NEURONS; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPTIC TRANSMISSION;

EID: 0035544160     PISSN: 12306002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. 4 receptors on inhibition in the guinea-pig dentate gyrus in vitro
2. Different receptor subtypes are involved in the serotonin-induced modulation of epileptiform activity in rat frontal cortex in vitro
3. Clinical and biochemical aspects of depressive disorders: II. Transmitter/receptor theories
4. Presynaptic enhancement of excitatory synaptic transmission by beta-adrenergic receptor activation
5. Effect of acute and chronic administration of citalopram on glutamate and aspartate release in the rat prefrontal cortex
6. Synaptic and intrinsic responses of medial entorhinal cortical cells in normal and magnesium-free medium in vitro
7. Effects of MK-801 and antidepressant drugs in the forced swimming
8. The electrophysiology of prefrontal serotonin systems: Therapeutic implications for mood and psychosis
9. Imipramine and phenelzine decrease glutamate overflow in the prefrontal cortex - A possible mechanism of neuroprotection in major depression?
10. The serotonergic and noradrenergic systems of the hippocampus: Their interactions and the effects of antidepressant treatments
11. 1B receptors
12. Functional comparison of neurotransmitter receptor subtypes in mammalian central nervous system
13. Chronic treatment with antidepressants affects glycine/NMDA receptor function: Behavioral evidence
14. Adaptation of N-methyl-D-aspartate (NMDA) receptors following antidepressant treatment: Implications for the pharmacotherapy of depression
15. Functional antagonists at the NMDA receptor complex exhibit antidepressant actions