New insights in health effects of trans α-linolenic acid isomers in humans

European Journal of Lipid Science and Technology

Volumn 103, Issue 7, 2001, Pages 478-482

  Chardigny, Jean Michel ^a   Bretillon, Lionel ^a   Sébédio, Jean Louis ^a  

^a CEMAGREF   (France)

Author keywords

Health effects; Human; Metabolism; Trans fatty acid

Indexed keywords

EID: 0035536801     PISSN: 14387697     EISSN: None     Source Type: Journal    
DOI: 10.1002/1438-9312(200107)103:7<478::aid-ejlt478>3.0.co;2-a     Document Type: Article

References (25)

1. G. Hénon, P. Y. Vigneron, B. Stoclin, J. Caigniez: Rapeseed oil deodorization study using the response surface methodology. Eur. J. Lipid Sci. Technol. 103 (2001) 467-477.
2. J. L. Sébédio, S. H. F. Vermunt, J. M. Chardigny, B. Beaufrère, R. P. Mensink, R. A. Armstrong, W. W. Christie, J. Niemelä, G. Hénon, R. A. Riemersma: The effect of dietary trans α-linolenic acid on plasma lipids and platelet fatty acid composition: the TransLine study. Eur. J. Clin. Nutr. 54 (2000) 104-113.
3. R. A. Armstrong, J. M. Chardigny, B. Beaufrère, L. Bretillon, S. H. F. Vermunt, R. P. Mensink, A. Macvean, R. A. Elton, J. L. Sébédio, R. A. Riemersma: No effect of dietary trans isomers of α-linolenic acid on platelet aggregation and haemostatic factors in European healthy men: the TRANSLinE study. Thromb. Res. 100 (2000) 133-141.
4. P. Legrand, J. M. Bourre, B. Descomps, G. Durand, S. Renaud: Lipides. In: Apports nutritionnels conseillés pour la population française. Ed. T. Doc, Paris (France) 2001, pp. 63-82.
5. G. Van Poppel: Intake of trans fatty acids in Western Europe: the TRANSFAIR study. Lancet 351 (1998) 1099.
6. R. Freese: Rapeseed oil and platelet function. Eur. J. Lipid Sci. Technol. 103 (2001) 483-489.
7. M. de Lorgeril, P. Salen, F. Laporte, T. Foulon, N. Payen, J. de Leiris: Rapeseed oil and rapeseed oil-based margarine for the prevention and treatment of coronary heart disease. Eur. J. Lipid Sci. Technol. 103 (2001) 490-495.
8. 14C) monotrans isomers of linoleic and α-linolenic acids in the rat. Biochim. Biophys. Acta 1390 (1998) 207-214.
9. L. Bretillon, J. M. Chardigny, J. L. Sébédio, J. P. Noël, C. Scrimgeour, C. Fernie, O. Loreau, P. Gachon, B. Beaufrère: Isomerization increases the post prandial oxidation of linoleic acid but not α-linolenic acid in men. J. Lipid Res. (2001) in press.
10. A. Jonas: Synthetic substrates of lecithin : cholesteryl acyltransferase. J. Lipid Res. 27 (1986) 689-698.
11. 14C mono-trans isomers of linoleic and α-linolenic acids in perfused rat liver. J. Lipid Res. 39 (1998) 2228-2239.
12. A. Grandgirard, A. Piconneaux, J. L. Sébédio, F. Julliard: Trans isomers of long-chain n-3 polyunsaturated fatty acids in tissue lipid classes of rats fed with heated linseed oil. Reprod. Nutr. Dev. 38 (1998) 17-29.
13. C. Loï, J. M. Chardigny, S. Almanza, L. Leclère, C. Giniès, J. L. Sébédio: Incorporation and metabolism of dietary trans isomers of linolenic acid alter the fatty acid profile of rat tissues. J. Nutr. 130 (2000) 2550-2555.
14. J. M. Chardigny, B. Bonhomme, J. L. Sébédio, P. Juanéda, J. M. Vatèle, M. Doly, A. Grandgirard: Effects of dietary trans n-3 polyunsaturated fatty acids on the rat electroretinogram. Nutr. Res. 18 (1998) 1711-1721.
15. J. P. Blond, C. Henchiri, P. Precigou, A. Grandgirard, J. L. Sébédio: Effect of 18:3 n-3 geometrical isomers of heated linseed oil on the biosynthesis of arachidonic acid in the rat. Nutr. Res. 10 (1990) 69-79.
16. C. Scrimgeour, A. Macvean, C. Fernie, J. L. Sébédio, R. A. Riemersma: Dietary trans α-linolenic acid does not inhibit Δ6-desaturation of linoleic acid in man. Eur. J. Lipid Sci. Technol. 103 (2001) 341-349.
17. R. P. Mensink, M. B. Katan: Effect of dietary trans fatty acids on high-density and low-density lipoprotein cholesterol levels in healthy subjects. N. Engl. J. Med. 323 (1990) 439-445.
18. S. H. F. Vermunt, B. Beaufrère, R. A. Riemersma, J. L. Sébédio, J. M. Chardigny, R. P. Mensink: Dietary trans α-linolenic acid from deodorised rapeseed oil and plasma lipids and lipoproteins in healthy men: the TRANSLinE study. Br. J. Nutr. (2001) in press.
19. B. Kinosian, H. Glick, G. Garland: Cholesterol and coronary heart disease: predicting risks by levels and ratios. Ann. Intern. Med. 121 (1994) 641-647.
20. M. J. Stampfer, F. M. Sacks, S. Salvini, W. C. Willett, C. H. Hennekens: A prospective study of cholesterol, apolipoproteins and the risk of myocardial infarction. N. Engl. J. Med. 325 (1991) 373-381.
21. C. Loi, J. M. Chardigny, O. Berdeaux, J. M. Vatèle, D. Poullain, J. P. Noël, J. L. Sébédio: Effects of three isomers of eicosapentaenoic acid on rat platelet aggregation and arachidonic metabolism. Thromb. Haemost. 80 (1998) 656-661.
22. T. Bachetti, L. Morbidelli: Endothelial cells in culture: a model for studying vascular functions. Pharmacol. Res. 42 (2000) 9-19.
23. V. Martinez-Sales, M. J. Gomez-Lechon, J. Gilabert: Characteristics of arachidonic acid metabolism of human endothelial cells in culture. Cytotechnology 3 (1990) 21-29.
24. J. M. Chardigny, J. L. Sébédio, P. Juanéda, J. M. Vatèle, A. Grandgirard: Occurrence of n-3 trans polyunsaturated fatty acids in humans platelets. Nutr. Res. 13 (1993) 1105-1111.
25. C. Loï, J. M. Chardigny, C. Cordelet, L. Leclère, M. Genty, C. Giniès, J. P. Noël, J. L. Sébédio: Incorporation and metabolism of trans 20:5 in endothelial cells. Effect on prostacyclin synthesis. Lipids 35 (2000) 911-918.