Carbohydrate-based chiral technology: Challenging the petro-chemistry paradigm: Compared with fossil fuel-derived chemicals, carbohydrates can be converted to optically active or chiral forms in fewer steps

Chemical Engineering

Volumn 108, Issue 12, 2001, Pages 66-69

  Hollingsworth, Rawle I ^a,b  

^a Synthon Chiragenics   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0035509778     PISSN: 00092460     EISSN: None     Source Type: Trade Journal    
DOI: None     Document Type: Article

References (9)

1. Process for the preparation of 3,4-dihydroxybutanoic acid and salts thereof. Hollingsworth, R.I., US. patents 5,292, 939 (1994); 5,319,110 (1994); and 5,374,773 plus several European and Canadian and Asian patents.
2. Hollingsworth, R.I., The chemical degradation of starch: Old reactions and new frontiers, Biotechnology Annual Review, 1996, 2, 281-291.
3. Hollingsworth, R.I. and Wang G., Towards a carbohydrate-based chemistry: Progress in the development of general-purpose chiral synthons from carbohydrates, Chemical Reviews, 100, 4267-4282, 2000.
4. Hollingsworth, R.I. and Wang G., Optically-active 3-carbon synthons: Another milestone in the creation of a general carbohydrate chiral technology platform, Chimica Oggi, 9, 40-42, 2000.
5. Hollingsworth, R. I., Carbohydrates for drug development, Specialty Chemicals, September 2000, pp. 242-243.
6. G. Wang and Hollingsworth, R.I., Synthetic Routes to L-Carnitine and L-Gamma-amino-beta-hydroxybutyric acid from (S)-3-hydroxy-butyrolactone by functional group priorities switching, Tetrahedron Asymmetry 10 1895-1901, 1999.
7. 4-cyano-3-hydroxybutanoyl hydrazines, derivatives and process for the preparation thereof, Hollingsworth R.I. and Wang, G., U.S. patent 6,114,566 (2000).
8. Hollingsworth, R. I., Taming carbohydrate complexity: A facile, high-yield route to chiral 3,4-dihydroxybutanoic acids and 4-hydroxytetrahydrofuran-2-ones with very high optical purity from pentose sugars, J. Org. Chem., 64, 7633-7634, 2000.
9. Process for the preparation of 3, 4-dihydroxybutanoic acid and derivatives thereof from substituted pentose sugars. Hollingsworth, R.I., U.S. patents 6,288,244 (2001).