Elevated in vivo frequencies of mutant T cells with altered functional expression of the T-cell receptor or hypoxanthine phosphoribosyltransferase genes in p53-deficient mice

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 483, Issue 1-2, 2001, Pages 13-17

  Suzuki, Takako ^a   Kusunoki, Yoichiro ^a   Tsuyama, Naohiro ^a   Ohnishi, Hisashi ^a   Seyama, Toshio ^a   Kyoizumi, Seishi ^a  

^a RADIATION EFFECTS RESEARCH FOUNDATION   (Japan)

Author keywords

HPRT; Ionizing radiation; p53; Somatic mutation; T cell receptor

Indexed keywords

HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; PROTEIN P53; T LYMPHOCYTE RECEPTOR;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MUTANT; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE MUTATION; GENOTYPE; HETEROZYGOTE; MALE; MOUSE; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; SOMATIC MUTATION; T LYMPHOCYTE; THYMOMA; WHOLE BODY RADIATION; X IRRADIATION;

ANIMALS; DNA DAMAGE; FEMALE; GENES, P53; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES;

EID: 0035500818     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(01)00227-5     Document Type: Article

References (21)

1. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
2. 14-3-3 Sigma is a p53-regulated inhibitor of G2/M progression
3. p53 regulates a G2 checkpoint through cyclin B1
4. p53, the cellular gatekeeper for growth and division
5. p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis
6. p53 mutations in human cancers
7. DNA damage, oncogenesis and the p53 tumour-suppressor gene
8. Mouse models in tumor suppression
9. Enhanced proliferative potential in culture of cells from p53-deficient mice
10. Development of a mouse model for studying in vivo T-cell receptor mutations
11. Measurement of in vivo HGPRT-deficient mutant cell frequency using a modified method for cloning human peripheral blood T-lymphocytes
12. Increased somatic cell mutant frequency in atomic bomb survivors
13. Chromosome instability contributes to loss of heterozygosity in mice lacking p53
14. Radiation-induced mutations at the autosomal thymidine kinase locus are not elevated in p53-null cells
15. Requirement of wild-type p53 protein for maintenance of chromosomal integrity
16. 1 mice exposed to N-ethyl-N-nitrosourea
17. Molecular analysis of hypoxanthine phosphoribosyl transferase mutants induced by glycidyl-1-naphthyl ether in mouse spleen cells in vivo
18. Mutant frequency at the H-2K class 1 and HPRT genes in T lymphocytes from the X-ray-exposed mouse
19. Stimulated rapid expression in vitro for early detection of in vivo T- cell receptor mutations induced by radiation exposure
20. Frequency of mutant T lymphocytes defective in the expression of the T-cell antigen receptor gene among radiation-exposed people
21. NK-mediated elimination of mutant lymphocytes that have lost expression of MHC class I molecules