Stimulated rapid expression in vitro for early detection of in vivo T-cell receptor mutations induced by radiation exposure

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 390, Issue 3, 1997, Pages 269-282

  Ishioka, Nahoko ^a   Umeki, Shigeko ^a,c   Hirai, Yuko ^a   Akiyama, Mitoshi ^a   Kodama, Takashi ^b   Ohama, Kozo ^b   Kyoizumi, Seishi ^a  

^a RADIATION EFFECTS RESEARCH FOUNDATION   (Japan)

^b HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^c Hibino Hospital   (Japan)

Author keywords

Biological dosimetry; In vivo somatic mutation; Radiation exposure; T cell receptor gene

Indexed keywords

INTERLEUKIN 2; PHYTOHEMAGGLUTININ; T LYMPHOCYTE RECEPTOR;

ARTICLE; CONTROLLED STUDY; DOSIMETRY; FEMALE; GYNECOLOGIC CANCER; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LYMPHOCYTE ACTIVATION; MUTATION; MUTATION RATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION EXPOSURE; SOMATIC MUTATION; TECHNIQUE;

EID: 0030942704     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(97)00025-9     Document Type: Article

References (42)

1. Albertini, R.J., K.L. Castle and W.R. Borcherding (1982) T-cell cloning to detect the mutant 6-thioguanine-resistant lymphocytes present in human peripheral blood, Proc. Natl. Acad. Sci. USA, 79, 6617-6621.
2. Morley, A.A., K.J. Trainor, R. Seshadri and R.G. Ryall (1983) Measurement of in vivo mutations in human lymphocytes, Nature, 302, 155-156.
3. Hakoda, M., M. Akiyama, S. Kyoizumi, A.A. Awa, M. Yamakido and M. Otake (1988) Increased somatic cell mutant frequency in atomic bomb survivors, Mutation Res., 201, 39-48.
4. Hirai, Y., Y. Kusunoki, S. Kyoizumi, A.A. Awa., D.J. Pawel, N. Nakamura and M. Akiyama, (1995) Mutant frequency at the HPRT locus in peripheral blood T-lymphocytes of atomic bomb survivors, Mutation Res., 329, 183-196.
5. Janatipour, M., K.J. Trainor, R. Kutlaca, G. Bennett, J. Hay, D.R. Turner and A.A. Morley (1988) Mutations in human lymphocytes studied by an HLA selection system, Mutation Res., 198, 221-226.
6. McCarron, M.A., A. Kutlaca and A.A. Morley (1989) The HLA-A mutation assay: improved technique and normal results, Mutation Res., 225, 189-193.
7. Kushiro, J., Y. Hirai, Y. Kusunoki, S. Kyoizumi, Y. Kodama, A. Wakisaka, A. Jeffreys, J.B. Cologne, K. Dohi, N. Nakamura and M. Akiyama (1992) Development of a flow-cytometric HLA-A locus mutation assay for human peripheral blood lymphocytes, Mutation Res., 272, 17-29.
8. Langlois, R.G., W.L. Bigbee and R.H. Jensen (1986) Measurements of the frequency of human erythrocytes with gene expression loss phenotypes at the glycophorin A locus, Human Genet., 74, 353-362.
9. Langlois, R.G., W.L. Bigbee, S. Kyoizumi, N. Nakamura, M.A. Bean, M. Akiyama and R.H. Jensen (1987) Evidence for increased somatic cell mutations at the glycophorin A locus in atomic bomb survivors, Science, 236, 445-448.
10. Kyoizumi, S., N. Nakamura, M. Hakoda, A.A. Awa, M.A. Bean, R.H. Jensen and M. Akiyama (1989) Detection of somatic mutations at the glycophorin A locus in erythrocytes of atomic bomb survivors using a single beam flow sorter, Cancer Res., 49, 581-588.
11. Cole, J. and T.R. Skopek (1994) Somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo, Mutation Res., 304, 33-105.
12. Akiyama, M., Y. Kusunoki, S. Umeki, Y. Hirai, N. Nakamura and S. Kyoizumi (1992) Evaluation of four somatic mutation assays as biological dosimeter in humans, in: W.C. Dewey, M. Edington, R.J.M. Fry, E.J. Hall and G.F. Whitmore (Eds.), Radiation Research: A Twentieth-Century Perspective. Vol. II: Congress Proceedings, Academic Press, New York, pp. 177-182.
13. Kyoizumi, S., M. Akiyama, Y. Hirai, Y. Kusunoki, K. Tanabe and S. Umeki (1990) Spontaneous loss and alteration of antigen receptor expression in mature CD4+ T cells, J. Exp. Med., 171, 1981-1999.
14. Kyoizumi, S., S. Umeki, M. Akiyama, Y. Hirai, Y. Kusunoki, N. Nakamura, K. Endoh, J. Konishi, M.S. Sasaki, T. Mori, S. Fujita and J.B. Cologne (1992) Frequency of mutant T lymphocytes defective in the expression of the T-cell antigen receptor gene among radiation-exposed people, Mutation Res., 265, 173-180.
15. Akiyama, M., S. Umeki, Y. Kusunoki, S. Kyoizumi, N. Nakamura, T. Mori, Y. Ishikawa, M. Yamakido, K. Ohama, K. Endo and J.B. Cologne (1995) Somatic-cell mutations as a possible predictor of cancer risk, Health Phys., 68, 643-649.
16. Umeki, S., Y. Kusunoki, K. Endo, K. Ohama, T. Kodama, M. Yamakido and M. Akiyama (1992) Somatic mutation at the TCR loci as a biological dosimeter of radiation-exposed people, Proc. Int. Conf. Rad. Effects and Protection, Mito, Japan, Japan Atomic Energy Research Instutute, Tokyo, pp. 151-154.
17. Umeki, S., S. Kyoizumi, Y. Kusunoki, N. Nakamura, M. Sasaki, T. Mori, Y. Ishikawa, J.B. Cologne and M. Akiyama (1991) Flow cytometric measurements of somatic cell mutations in thorotrast patients, Jpn. J. Cancer Res., 82, 1349-1353.
18. Akleyev, A.V., M.M. Kosseno, L.A. Silkina, M.D. Degteva, V.A. Yachmenyov, A.A. Awa, M. Akiyama, G.A. Veremeyeva, A.V. Vozilova, S. Kyoizumi, V.P. Kozeurov and O.V. Vyushkova (1995) Health effects of radiation incidents in the Southern Urals, Stem Cells, 13 (Suppl. 1), 58-68.
19. Iwamoto, K.S., Y. Hirai, S. Umeki, Y. Kusunoki, S. Kyoizumi, T. Kodama, K. Ohama, N. Nakamura and M. Akiyama (1994) A positive correlation between T-cell-receptor mutant frequencies and dicentric chromosome frequencies in lymphocytes from radiotherapy patients, J. Radiat. Res. (Tokyo), 35, 92-103.
20. Iwamoto, K.S., T. Mizuno, T. Itoh, N. Tsuyama, S. Kyoizumi and T. Seyama (1996) Gain-of-function p53 mutations enhance alteration of the T-cell receptor following X-irradiation, independently of the cell cycle and cell survival, Cancer Res., 56, 3862-3865.
21. Akiyama, M., S. Kyoizumi, Y. Hirai, Y. Kusunoki, K.S. Iwamoto and N. Nakamura (1995) Mutation frequency in human blood cells increases with age, Mutation Res., 338, 141-149.
22. Bender, M.A., A.A. Awa, A.L. Brooks, H.J. Evans, P.G. Groer, L.G. Littlefield, C. Pereira and R.J. Preston (1988) Current status of cytogenetic procedures to detect and quantify previous exposures to radiation, Mutation Res., 196, 103-159.
23. Kronenberg, M., G. Sin, L.E. Hood and N. Shastri (1986) The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition, Annu. Rev. Immunol., 4, 529-591.
24. Clevers, H., B. Alarcon, T. Wileman and C. Terhost (1988) The T cell receptor/CD3 complex: a dynamic protein ensemble, Annu. Rev. Immunol., 6, 629-662.
25. Chen, C., J.S. Bonifacino, L.C. Yuan and R.D. Klausner (1988) Selective degradation of T cell antigen receptor chains retained in a pre-Golgi compartment, J. Cell Biol., 107, 2149-2161.
26. Koning, F., A.M. Lew, W.L. Maloy, R. Valas and J.E. Coligan (1988) The biosynthesis and assembly of T cell receptor a- and b-chains with the CD3 complex, J. Immunol., 140, 3126-3134.
27. Saito, T., A. Weiss, K.C. Gunter, E.M. Shevach and R.N. Germain (1987) Cell surface T3 expression requires the presence of both a- and b-chains of the T cell receptor, J. Immunol., 139, 625-628.
28. Saito, T., A. Weiss, J. Miller, M.M. Norcross and R.N. Germain (1987) Specific antigen-Ia activation of transfected human T cells expressing murine Ti-human T3 receptor complexes, Nature, 325, 125-130.
29. Padovan, E., G. Casorati, P. Dellabona, S. Meyer, M. Brockhaus and A. Lanzavecchia (1993) Expression of two T cell receptor a chains: dual receptor T cells, Science, 262, 422-424.
30. Sanderson, B.J.S., J.L. Dempsey and A.A. Morley (1984) Mutation in human lymphocytes: effect of X- and UV-irradiation, Mutation Res., 140, 223-227.
31. Buckton, K.E., P.G. Smith and W.M. Court-Brown (1967) The estimation of lymphocytes lifespan from studies on males treated with X-rays for ankylosing spondylitis, in: H.J. Evans, W.M. Court-Brown and A.S. McLean (Eds), Human Radiation Cytogenetics, North-Holland, Amsterdam, pp. 106-114.
32. Lloyd, D.C., R.J. Purrott and E.J. Reeder (1980) The incidence of unstable chromosome aberrations in peripheral blood lymphocytes from unirradiated and occupationally exposed people, Mutation Res., 72, 523-532.
33. Norman A., S.M. Sasaki, R.E. Ottoman and A.G. Fingerhut (1965) Lymphocyte lifetime in women, Science, 147, 745.
34. Norman A., M.S. Sasaki, R.E. Ottoman and A.G. Fingerhut (1966) Elimination of chromosome aberrations from human lymphocytes, Blood, 27, 706-714.
35. Ramalho, A.T. and C.H. Nascimento (1991) The fate of chromosomal aberrations in 137Cs-exposed individuals in the Goiania radiation accident, Health Phys., 60, 67-70.
36. Leonard, A., G. Decat, E.D. Leonard, A. Wambersie and J. Renard (1987) Chromosome aberrations in patients irradiated for pelvic tumours, Strahlentherapie Onkol., 163, 795-799.
37. Bender, M.A. and J.G. Brewen (1969) Factors influencing chromosome aberration yields in the human peripheral leukocyte system, Mutation Res., 8, 383-399.
38. Lloyd, D.C., R.J. Purrott, G.W. Dolphin, D. Bolton and A.A. Edwards (1975) The relationship between chromosome aberrations and low LET radiation dose to human lymphocytes, Int. J. Radiat. Biol., 28, 75-90.
39. Sasaki, M.S. (1971) Radiation-induced chromosome aberrations in lymphocytes: possible biological dosimeter in man, in: T. Sugahara and O. Hug (Eds.), Biological Aspect of Radiation Protection, Springer, Berlin, pp. 81-91.
40. Dolphin, G.W. (1969) Biological dosimetry with particular reference to chromosome aberration analysis. A review of methods. Handling of Radiation Accidents (Proc. Int. Symp. Vienna, 1969), IAEA, Vienna, pp. 215-224.
41. Ekstrand, K.E., R.L. Dixon, S. Plunkett and M. Raben (1981) The calculation of the dose to lymphocytes in external beam radiation therapy, Radiat. Res., 85, 399-407.
42. Sasaki, M.S., H. Miyata (1968) Biological dosimetry in atomic bomb survivors, Nature, 220, 1189-1193.