High frequency of constitutive alkali-labile sites in mouse major satellite DNA, detected by DNA breakage detection-fluorescence in situ hybridization

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 483, Issue 1-2, 2001, Pages 43-50

  Rivero, M T ^a   Vazquez Gundin F ^a   Goyanes, V ^b   Campos, A ^b   Blasco, M ^c   Gosalvez J ^d   Fernandez J L ^a  

^a Centro Oncologico de Galicia   (Spain)

^b UNIVERSITY OF A CORUÑA   (Spain)

^c CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^d UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Alkali labile sites; DNA breakage detection FISH (DBD FISH); DNA breaks; Major satellite; Satellite DNA

Indexed keywords

SATELLITE DNA; SINGLE STRANDED DNA; SODIUM HYDROXIDE;

ADULT; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA HYBRIDIZATION; DNA PROBE; DNA SEQUENCE; DNA STRAND BREAKAGE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; IMAGE ANALYSIS; LEUKOCYTE; MALE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; SPLEEN CELL;

EID: 0035500464     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(01)00218-4     Document Type: Article

References (27)

1. Application of FISH for in situ detection and quantification of DNA breakage
2. Application of FISH to detect DNA damage: DNA breakage detection-FISH (DBD-FISH)
3. The rate of strand separation in alkali of DNA of irradiated mammalian cells
4. DNA breakage detection-FISH (DBD-FISH): Effect of unwinding time
5. DNA breakage detection-FISH (DBD-FISH) in human spermatozoa: Technical variants evidence different structural features
6. Abundant alkali-sensitive sites in DNA of human and mouse sperm
7. Evidence of abundant constitutive alkali-labile sites in human 5 bp classical satellite DNA loci by DBD-FISH
8. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates
9. Human chromosome-specific repetitive DNA sequences: Novel markers for genetic analysis
10. Mouse major (γ) satellite DNA is highly conserved and organized into extremely long tandem arrays: Implications for recombination between non-homologous chromosomes
11. Mouse minor satellite DNA genetically maps to the centromere and is physically linked to the proximal telomere
12. Mammalian chromosome structure
13. Highly sensitive apurinic/apyrimidinic site assay can detect spontaneous and chemically induced depurination under physiological conditions
14. A method for detecting abasic sites in living cells: Age dependent changes in base excision repair
15. Repair of chromosomal abasic sites in vivo involves at least three different repair pathways
16. Depurination of DNA as a possible mutagenic pathway for cells
17. Mutational specificity of depurination
18. Spontaneous DNA lesions poison human topoisomerase II alpha and stimulate cleavage proximal to leukemic 11q23 breakpoints
19. Breakpoints in Robertsionan translocations are localized to satellite III DNA by fluorescence in situ hybridization
20. Alkali-labile sites are prevalent in kidney tissue DNA
21. Centromeres: Proteins, protein complexes, and repeated domains at centromeres of simple eukaryotes
22. New insights into the structure of abasic DNA from molecular dynamics simulations