Mass spectral analysis of asymmetric hemoglobin hybrids: Demonstration of Hb FS (α2 γβs) in sickle cell disease

Analytical Biochemistry

Volumn 298, Issue 1, 2001, Pages 76-82

  Ofori Acquah, Solomon F ^a   Green, Brian N ^b   Davies, Sally C ^c   Nicolaides, Kypros H ^a   Serjeant, Graham R ^d   Layton, D Mark ^c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b MICROMASS UK LTD   (United Kingdom)

^c IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^d MRC Laboratories   (Jamaica)

Author keywords

Asymmetric hemoglobin hybrids; Fetal hemoglobin; Mass spectrometry; Noncovalent association; Sickle cell disease

Indexed keywords

BLOOD; CYTOLOGY; DIMERS; ELECTRODEPOSITION; ELECTROPHORESIS; ELECTROSPRAY IONIZATION; HEMOGLOBIN; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SPECTRUM ANALYSIS;

ASYMMETRIC HEMOGLOBIN HYBRIDS; CONVENTIONAL METHODS; ELECTROSPRAY IONIZATION MASS SPECTROMETRY; MASS-SPECTRAL ANALYSIS; NONCOVALENT ASSOCIATION; PHYSIOLOGICAL CONDITION; PROTECTIVE EFFECTS; SICKLE CELL DISEASE;

CELLS;

HEMOGLOBIN F; HEMOGLOBIN S; HYBRID PROTEIN; UNCLASSIFIED DRUG;

ADULT; APPARATUS; ARTICLE; CALCULATION; CHILD; COMPLEX FORMATION; DISSOCIATION; FEMALE; FETUS; HEMOGLOBIN FS; HEMOLYSATE; HUMAN; HUMAN TISSUE; MALE; MASS SPECTROMETER; MASS SPECTROMETRY; MOLECULAR WEIGHT; PREDICTION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SICKLE CELL ANEMIA;

EID: 0035499482     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1006/abio.2001.5358     Document Type: Article

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