Suramin inhibits respiration and induces membrane permeability transition in isolated rat liver mitochondria

Toxicology

Volumn 169, Issue 1, 2001, Pages 17-23

  Bernardes, Celene F ^a,b   Fagian, Marcia M ^a   Meyer Fernandes, José R ^c   Castilho, Roger F ^a   Vercesi, Anibal E ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b PONTIFÍCIA UNIVERSIDADE CATÓLICA DE CAMPINAS   (Brazil)

^c FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Ca2+; Isolated rat liver mitochondria; Mitochondrial membrane permeability transition; Suramin; Thiol oxidation

Indexed keywords

2 OXOGLUTARIC ACID; ADENOSINE DIPHOSPHATE; CALCIUM ION; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; CYCLOSPORIN A; FLAVINE ADENINE NUCLEOTIDE; ISOCITRIC ACID; MAGNESIUM ION; MALIC ACID; N,N,N',N' TETRAMETHYL 1,4 PHENYLENEDIAMINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; S 2671; SUCCINIC ACID; SURAMIN; THIOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREATHING; CONTROLLED STUDY; DOSE RESPONSE; LIVER MITOCHONDRION; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; MITOCHONDRION SWELLING; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT;

ADENOSINE DIPHOSPHATE; ANIMALS; CARBONYL CYANIDE P-TRIFLUOROMETHOXYPHENYLHYDRAZONE; CELL MEMBRANE PERMEABILITY; CELL RESPIRATION; CHELATING AGENTS; CYCLOSPORINE; DRUG INTERACTIONS; EGTAZIC ACID; ENZYME INHIBITORS; ETHYLMALEIMIDE; INTRACELLULAR MEMBRANES; MAGNESIUM; MEMBRANE POTENTIALS; MITOCHONDRIA, LIVER; MITOCHONDRIAL SWELLING; OXYGEN CONSUMPTION; RATS; RATS, WISTAR; SULFHYDRYL REAGENTS; SURAMIN; TRYPANOCIDAL AGENTS;

EID: 0035499068     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(01)00477-2     Document Type: Article

References (32)

1. 2+-dependent permeabilization of the inner mitochondrial membrane by 4,4′-diisothyocyanatostilbene-2,2′-disulfonic acid (DIDS)
2. Inhibition of succinic dehydrogenase and F0F1-ATP synthase by 4,4′-diisothyocyanatostilbene-2,2′-disulfonic acid (DIDS)
3. The permeability transition pore: Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death
4. Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria
5. Inhibition by suramin of mitochondrial ATP synthesis
6. 2+ ions is stumulated by t-butyl hydroperoxide and mediated by reactive oxygen species generated by mitochondria
7. 2+ plus prooxidants is determined by the extent of membrane protein thiol cross-linking
8. 2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress
9. 2+ plus prooxidants
10. Uptake of the trypanocidal drug suramin by bloodstream forms of Trypanosoma brucei and its effect on respiration and growth rate in vivo
11. Determination of serum proteins by means of biuret reaction
12. Mitochondrial non-specific pores remain closed during cardiac isquemia but open upon reperfusion
13. Mechanisms by which mitochondria transport calcium
14. Oxidative stress, thiol reagents and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase
15. 2+ acting at the external side of the inner mitochondrial membrane can stimulate mitochondrial permeability transition induced by phenylarsine oxide
16. Mitochondrial damage induced by conditions of oxidative stress
17. 2+ ions. A proposed model for phosphate-stimulated lipid peroxidation
18. 2+: Correlation with mitochondrial permeability transition
19. The thiol-specific antioxidant enzyme prevents mitochondrial permeability transition: Evidence for the involvement of reactive oxygen species in this mechanism
20. Calcium in ischemic cell death
21. Phenylarsine oxide induced the cyclosporin A-sensitive membrane permeability transition in rat liver mitochondria
22. 2+ homeostasis in hearts reperfused after prolonged episodes of ischemia
23. Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A
24. Cyclosporin and carnitine prevent the anoxic death of culture hepatocytes by inhibiting the mitochondrial permeability transition
25. Disruption of cellular energy balance by suramin in intact human prostatic carcinoma cells, a likely antiproliferative mechanism
26. Disruption of mitochondrial function by suramin measured by rhodamine 123 retention and oxygen consumption in intact DU145 prostate carcinoma cells
27. Inhibition by suramin of oxidative phosphorylation in Crithidia fasciculata
28. The participation of reactive oxygen species and protein thiols in the mechanism of mitochondrial inner membrane permeabilization by calcium plus prooxidants
29. +-induced alterations of rat liver and hepatoma mitochondrial membrane permeability
30. Recent research on the biological activity of suramin
31. The redox state of endogenous pyridine nucleotides can determine both the degree of mitochondrial oxidative stress and the solute selectivity of the permeability transition pore
32. The mitochondrial permeability transition