Cytochrome P450s: Coupling development and environment

Trends in Genetics

Volumn 17, Issue 11, 2001, Pages 629-632

  Stoilov, Ivaylo ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; DIOXIN; MORPHOGEN; XENOBIOTIC AGENT;

CELL DIFFERENTIATION; CELL GROWTH; EMBRYO DEVELOPMENT; GENETIC TRANSCRIPTION; HUMAN; LIGAND BINDING; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW;

EID: 0035499065     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(01)02444-1     Document Type: Review

References (34)

1. Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21
2. Sequence analysis and homology modeling suggests that primary congenital glaucoma on 2p21 results from mutations disrupting either the hinge region or the conserved core structures of cytochrome P4501B1
3. Mutations in CYP1B1, the gene for cytochrome P450 1B1, are the predominant cause of primary congenital glaucoma in Saudi Arabia
4. Identification of a single ancestral CYP1B1 mutation in Slovak Gypsies (Roms) affected with primary congenital glaucoma
5. Proposed role of drug-metabolizing enzymes: Regulation of steady state levels of the ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions
6. The Drosophila disembodied gene controls late embryonic morphogenesis and codes for a cytochrome P450 enzyme that regulates embryonic ecdysone levels
7. Changes in the shapes of leaves and flowers upon overexpression of cytochrome P450 in Arabidopsis
8. A mutation in the eln2 gene encoding a cytochrome P450 of Coprinus cinereus affects mushroom morphogenesis
9. Biosynthesis of all-trans-retinoic acid from all-trans retinol: Catalysis of all-trans-retinol oxidation by human P-450 cytochromes
10. The role of retinoic acid in embryonic and post-embryonic development
11. A genetic dissection of the retinoid signaling pathway in the mouse
12. Ecdysone pathway is required for furrow progression in the developing Drosophila eye
13. The distribution of endogeneous retinoic acid in the chick embryo: Implications for developmental mechanisms
14. Complementary domains of retinoic acid production and degradation in the early chick embryo
15. Molecular identification of a major retinoic-acid-synthesizing enzyme, a retinaldehyde-specific dehydrogenase
16. Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase
17. Regionalized metabolic activity establishes boundaries of retinoic acid signaling
18. Expression of retinoic acid 4-hydroxylase (CYP26) during mouse and Xenopus laevis embryogenesis
19. Dorsal and ventral territories defined by retinoic acid synthesis break-down and nuclear receptor expression
20. Positional information and the spatial pattern of cellular differentiation
21. Diffusion in embryogenesis
22. Morphogens and pattern formation
23. The relation of maternal vitamin A deficiency to microphthalmia in pigs
24. Calcium influx factor, further evidence it is 5,6-epoxyeicosatrienoic acid
25. s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids
26. 11,12-Epoxyeicosatrienoic acid stimulates tyrosine kinase activity in porcine aortic endothelial cells
27. Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids
28. Differentiating keratinocytes express a novel cytochrome P450 enzyme, CYP2B19, having arachidonate monooxygenase activity
29. Overexpression of C-terminal Src kinase blocks 14,15-epoxyeicosatrienoic acid-induced tyrosine phosphorylation and mitogenesis
30. Molecular cloning, enzymatic characterization, developmental expression, and cellular localization of a mouse cytochrome P450 highly expressed in kidney
31. Cytochrome P450 CYP2J9, a new mouse arachidonic acid ω-1 hydroxylase predominantly expressed in brain
32. Regio and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase
33. Current status of teratology
34. Two novel sites of expression of NADPH cytochrome P450 reductase during murine embryogenesis: Limb mesenchyme and developing olfactory neuroepithelia