TH2 lymphocytes secrete functional VIP upon antigen stimulation

Archives of Physiology and Biochemistry

Volumn 109, Issue 4, 2001, Pages 365-368

  Vassiliou, E ^a   Jiang, X ^a   Delgado, M ^a   Ganea, D ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

Atigen stimulation; TH2 cells; Vasoactive intestinal peptide

Indexed keywords

CYCLIC AMP; CYTOCHROME C; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE RECEPTOR; MESSENGER RNA; MONOCLONAL ANTIBODY; OVALBUMIN; RECOMBINANT GAMMA INTERFERON; RECOMBINANT INTERLEUKIN 2; RECOMBINANT INTERLEUKIN 4; T LYMPHOCYTE RECEPTOR; VASOACTIVE INTESTINAL POLYPEPTIDE;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; MOUSE; NONHUMAN; NORTHERN BLOTTING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; TH1 CELL; TH2 CELL; TRANSGENIC MOUSE;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS; CELL SEPARATION; CYCLIC AMP; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; OVALBUMIN; PEPTIDES; RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE; RECEPTORS, VASOACTIVE INTESTINAL POLYPEPTIDE, TYPE I; TH1 CELLS; TH2 CELLS; VASOACTIVE INTESTINAL PEPTIDE;

ANIMALIA; COLUMBA; MUS MUSCULUS;

EID: 0035496990     PISSN: 13813455     EISSN: None     Source Type: Journal    
DOI: 10.1076/apab.109.4.365.4245     Document Type: Article

References (14)

1. Delgado M, Ganea D (2001): Cutting Edge: Is Vasoactive Intestinal peptide a Type 2 Cytokine? J Immunol 166: 2907-2912.
2. Delgado M, Leceta J, Gomariz RP, Ganea D (1999a): VIP and PACAP stimulate the induction of Th2 responses by up-regulating B7.2 expression. J Immunol 163: 3629-3635.
3. Delgado M, Martinez C, Leceta J, Garrido E, Gomariz RP (1996b): Differential VIP and VIP1 receptor gene expression in rat thymocyte subsets. Peptides 17: 803-807.
4. Delgado M, Pozo D, Martinez C, Garrido E, Leceta J, Calvo JR, Gomariz RP (1996a): Characterization of gene expression of VIP and VIP1-receptor in rat peritoneal lymphocytes and macrophages. Regul Pept 62: 161-166.
5. Delgado M, Munoz-Elias EJ, Gomariz RP, Ganea D (1999b): VIP and PACAP inhibit IL-12 production in LPS-stimulated macrophages. Subsequent effect on IFNγ synthesis by T Cells. J Neuroimmunol 96: 167-181.
6. Ganea D, Delgado M (2001): Inhibitory neuropeptide receptors on macrophages. Microbes and Infection 3: 141-147.
7. Goetzl EJ, Sreedharan SP, Turck DW (1988): Structurally distinctive vasoactive intestinal peptides from rat basophilic leukemia cells. J Biol Chem 263: 9083-9086.
8. Gomariz RP, Leceta J, Garrido E, Garrido T, Delgado M (1994): Vasoactive intestinal peptide (VIP) mRNA expression in rat T and B lymphocytes. Regul Pept 50: 177-184.
9. Leceta J, Martinez C, Delgado M, Garrido E, Gomariz RP (1994): Lymphoid cell subpopulations containing vasoactive intestinal peptide in rat. Peptides 15: 791-797.
10. Leceta J, Martinez C, Delgado M, Garrido E, Gomariz RP (1996): Expression of vasoactive intestinal peptide in lymphocytes: A possible endogenous role in the regulation of the immune system. Adv Neuroimmunol 6: 29-36.
11. Martinez C, Delgado M, Abad C, Gomariz RP, Ganea D, Leceta J (1999): Regulation of VIP production and secretion by murine lymphocytes. J Neuroimmunol 93: 126-138.
12. Seder RA, Paul WE, David MM, Fazekas S, Groth B (1992): The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. d J Exp Med 176: 1091-1098.
13. Swain SL (1994): Generation and in vivo persistence of polarized Thl and Th2 memory cells. Immunity 1: 543-552.
14. Weinstock JV, Blum AM (1990): Detection of vasoactive intestinal peptide and localization of its mRNA within granulomas of murine schistosomiasis. Cell Immunol 125: 291-300.