Apoptosis and proliferative activity in mature and immature teratomas of the mediastinum

Cancer

Volumn 92, Issue 7, 2001, Pages 1798-1806

  Hiroshima, Kenzo ^a   Toyozaki, Tetsuya ^a   Iyoda, Akira ^a   Yusa, Toshikazu ^b   Fujisawa, Takehiko ^a   Ohwada, Hidemi ^a  

^a CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b CHIBA ROSAI HOSPITAL   (Japan)

Author keywords

Apoptosis; Bax; Bcl 2; Mediastinum; p53; Teratoma; fetoprotein

Indexed keywords

ALPHA FETOPROTEIN; CYCLINE; DNA; FORMALDEHYDE; PARAFFIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

ADOLESCENT; ADULT; APOPTOSIS; ARTICLE; CANCER DIAGNOSIS; CANCER GROWTH; CANCER SURGERY; CELL PROLIFERATION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; FEMALE; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MALIGNANT TERATOMA; MEDIASTINUM CANCER; MEDIASTINUM TUMOR; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TERATOMA; TREATMENT OUTCOME; TUMOR GROWTH;

ADOLESCENT; ADULT; ALPHA-FETOPROTEINS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL DIVISION; CHILD; DNA, NEOPLASM; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MEDIASTINAL NEOPLASMS; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROGNOSIS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TERATOMA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035476972     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0142(20011001)92:7<1798::AID-CNCR1696>3.0.CO;2-V     Document Type: Article

References (41)

1. Germ cell tumors of the mediastinum
2. Malignant germinal neoplasms of the mediastinum
3. Malignant mediastinal teratoma in a 15-year-old girl
4. Alpha-fetoprotein-producing immature mediastinal teratoma showing rapid and massive recurrent growth in an adult
5. Results of modern therapy for patients with mediastinal nonseminomatous germ cell tumors
6. p53 Tumor suppressor gene: From the basic research laboratory to the clinic - An abridged historical perspective
7. Mutations of the p53 gene do not occur in testis cancer
8. No germline TP53 mutations detected in familial and bilateral testicular cancer
9. Human male germ cell tumor resistance to cisplatin is linked to TP53 gene mutation
10. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
11. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax
12. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
13. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
14. p53 Mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines
15. A new method for sequencing DNA
16. Tumor markers in testicular cancer-an update
17. Mixed germ cell tumors of the ovary
18. Alpha-fetoprotein in malignant germ cell tumors of the ovary
19. Mediastinal growing teratoma syndrome
20. Alpha-fetoprotein localization in pure ovarian teratoma
21. Solid teratomas and mixed Müllerian tumors of the ovary: A clinical, histological, and immunocytochemical comparative study
22. Pathology of germ cell tumors of testis: A progress report
23. p53 Protein alterations in human testicular cancer including pre-invasive intratubular germ-cell neoplasia
24. Immunohistochemical expression of P53 tumor suppressor gene protein in adult germ cell testis tumors: Clinical correlation in Stage I disease
25. High incidence of p53 gene mutation in human ovarian cancer and its association with nuclear accumulation of p53 protein and tumor DNA aneuploidy
26. p53 Mutation in carcinomas arising in ovarian cystic teratomas
27. Quantitation and characterization of a species-specific and embryo stage-dependent 55-kilo-dalton phosphoprotein also present in cells transformed by simian virus 40
28. The phospho-protein p53 is down-regulated post-transcriptionally during embryogenesis in vertebrates
29. Extent of apoptosis in relation to p53 and bcl-2 expression in germ cell tumors
30. Bcl-2 protein in non-small-cell lung carcinoma
31. Bcl-2 protein: A prognostic factor inversely correlated to p53 in non-small-cell lung cancer
32. Bcl-2 protein expression and long-term survival in breast cancer
33. Expression and prognostic significance of Bcl-2 in ovarian tumours
34. Bcl-2 expression and its association with cell kinetics in human gastric carcinomas and intestinal metaplasia
35. The prognostic significance of p53 and bcl-2 expression in lung adenocarcinoma and its correlation with Ki-67 growth fraction
36. Apoptosis, cell proliferation and expression of Bcl-2 and Bax in gastric carcinomas: Immunohistochemical and clinicopathological study
37. BAX protein expression and clinical outcome in epithelial ovarian cancer
38. Immature teratoma in children
39. Primary mediastinal germ cell tumors in children and adolescents: Results of the German cooperative protocols MAKEI 83/86, 89, and 96
40. Benign clinical behavior of immature mediastinal teratoma in infancy and childhood: Report of two cases and review of the literature