Biodistribution of charged F(ab')2 photoimmunoconjugates in a xenograft model of ovarian cancer

British Journal of Cancer

Volumn 75, Issue 6, 1997, Pages 837-844

  Duska, L R ^a   Hamblin, M R ^a   Bamberg, M P ^a   Hasan, T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Chlorin; Monoclonal antibody; Photodynamic therapy; Photoimmunotherapy; Photosensitizer; Polylysine

Indexed keywords

ANTIBODY CONJUGATE; CATION; CHLORIN; IMMUNOGLOBULIN F(AB) FRAGMENT; IODINE 125; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 125; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER IMMUNOTHERAPY; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CONJUGATION; DRUG DEGRADATION; DRUG DISTRIBUTION; DRUG LIVER LEVEL; DRUG SELECTIVITY; DRUG TISSUE LEVEL; DRUG TUMOR LEVEL; ENDOCYTOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOREACTIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; ISOTOPE LABELING; LYSOSOME; MOUSE; NONHUMAN; NUDE MOUSE; OVARY CANCER; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; XENOGRAFT;

EID: 0031039913     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.149     Document Type: Article

References (38)

1. Abernethy NJ, Chin W, Hay JB, Rodela H, Oreopoulos D and Johnston MG (1991) Lymphatic drainage of the peritoneal cavity in sheep. Am J Physiol 260: F353-F358
2. Beck E, Hofmann M, Bernhardt G, Jager W, Wildt L and Lang N (1994) In vitro activity of immunoconjugates between cisplatin and an anti-CA125 monoclonal antibody on ovarian cancer cell lines. Cell Biophys 25: 163-173
3. 2 fragments are more efficient and less toxic than intact anti-CEA antibodies in radioimmunotherapy of large human colon carcinoma grafted in nude mice. J Nucl Med 31: 1035-1044
4. Carroll SF, Bernhard SL, Goff DA, Bauer RJ, Leach W and Kung AH (1994) Enhanced stability in vitro and in vivo of immunoconjugates prepared with 5-methyl-2-iminothiolane. Bioconjug Chem 5: 248-256
5. Delaney TF, Sindelar WF, Tochner Z, Smith PD, Friauf WS, Thomas G, Dachowski L, Cole JW, Steinberg SM and Glatstein E (1993) Phase I study of debulking surgery and photodynamic therapy for disseminated intraperitoneal tumours. Int J Radiat Oncol Biol Phys 25: 445-457
6. Fisher AM, Murphree AL and Gomer CJ (1995) Clinical and preclinical photodynamic therapy. Lasers Surg Med 17: 2-31
7. Flessner MF and Dedrick RL (1994) Monoclonal antibody delivery to intraperitoneal tumors in rats: effects of route of administration and intraperitoneal solution osmolality. Cancer Res 54: 4376-4384
8. Goff BA, Bamberg M and Hasan T (1991) Photoimmunotherapy of human ovarian carcinoma cells ex vivo. Cancer Res 51: 4762-4767
9. Goff BA, Bamberg M and Hasan T (1992) Experimental photodynamic treatment of ovarian carcinoma cells with immunoconjugates. Antibody Immunoconj Radiopharm 5: 191-199
10. Goff BA, Hermanto U, Rumbaugh J, Blake J, Bamberg M and Hasan T (1994) Photoimmunotherapy and biodistribution with an OC125-chlorin immunoconjugate in an in vivo murine ovarian cancer model. Br J Cancer 70: 474-480
11. Haisma HJ, Moseley KR, Battaile AI, Griffiths TC, Zurawski VR and Knapp RC (1988) Biodistribution, pharmacokinetics and imaging of 1311-labelled OC125 in ovarian cancer. Int J Cancer 2 (suppl.): 109-113
12. Hamblin MR, Miller JL and Hasan T (1996) The effect of charge on the interaction of site-specific photosensitizer immunoconjugates with human ovarian cancer cells. Cancer Res 56: 5205-5210
13. Hamblin MR and Newman EL (1994) Photosensitizer targeting in photodynamic therapy. II. Conjugates of haematoporphyrin with serum lipoproteins. J Photochem Photobiol B 26: 147-157
14. Hansen SH, Sandvig K and Van Deurs B (1993) Molecules internalized by clathrin-independent endocytosis are delivered to endosomes containing transferrin receptors. J Cell Biol 123: 89-97
15. Hasan T (1992) Photosensitizer delivery mediated by macromolecular carrier systems. In Photodynamic Therapy: Basic Principles and Clinical Applications, Henderson B and Dougherty T (eds) pp. 187-200. Marcel Dekker: New York
16. Hasan T and Parrish JA (1996) Photodynamic therapy of cancer. In Cancer Medicine, 4th edn. Holland JF, Frei E, Bast RC, Kufe DW, Morton DL and Weichselbaum RR (eds.), pp. 739-751. Williams & Wilkins: Baltimore (in press)
17. Henderson BW and Dougherty TJ (1992) How does photodynamic therapy work? Photochem Photobiol 55: 145-157
18. Hosono MN, Endo K, Sakahara H, Watanabe Y, Saga T, Nakai T, Hosono M, Nakajima T, Onoyama Y and Konishi J (1992) Different antigenic nature in apparently healthy women with high serum CA 125 levels compared with typical patients with ovarian cancer. Cancer 70: 2851-2856
19. Karlan BY, Amin W, Casper SE and Littlefield BA (1988) Hormonal regulation of CA125 tumor marker expression in human ovarian carcinoma cells: inhibition by glucocorticoids. Cancer Res, 48: 3502-3506
20. Molpus KL, Kato D, Hamblin MR, Lilge L, Bamberg M and Hasan T (1996a) Intraperitoneal photodynamic therapy of human epithelial ovarian carcinomatosis in a xenograft murine model. Cancer Res, 56: 1075-1082
21. Molpus KL, Koelliker D, Atkins L, Kato D, Buczek-Thomas J, Fuller AFJ and Hasan T (1996b) Characterization of a xenograft model of human ovarian carcinoma which produces intraperitoneal carcinomatosis and metastases in mice. Int J Cancer 67: 588-595
22. Muto MG, Finkler NJ, Kassis AI, Howes AE, Anderson LL, Lau CC, Zurawski VR, Jr. Weadock K, Tumeh SS, Lavin P and Knapp RC (1992) Intraperitoneal radioimmunotherapy of refractory ovarian carcinoma utilizing iodine-131-labeled monoclonal antibody OC125. Gynecol Oncol. 45: 265-272
23. Ozols RF (1995) Carboplatin and paclitaxel in ovarian cancer. Semin Oncol, 22: 78-83
24. Pardridge WM, Bickel U, Buciak J, Yang J and Diagne A (1994a) Enhanced endocytosis and anti-humun immunodeficiency virus type 1 activity of anti-rev antibodies after cationization. J Infect Dis, 169: 55-61
25. Pardridge WM, Bickel U, Buciak J, Yang J, Diagne A and Aepinus C (1994b) Cationization of a monoclonal antibody to the human immunodeficiency virus REV protein enhances cellular uptake but does not impair antigen binding of the antibody. Immunol Lett 42: 191-195
26. Parker SE, Tong T, Bolden S and Wingo PA (1996) Cancer statistics 1996. CA Cancer J Clin, 46: 5-28
27. Press OW, Hansen JA, Farr A and Martin PJ (1988) Endocytosis and degradation of murine anti-human CD3 monoclonal antibodies by normal and malignant T-lymphocytes. Cancer Res, 48: 2249-2257
28. Press OW, Desantes K, Anderson SK and Geissler F (1990) Inhibition of catabolism of radiolabeled antibodies by tumor cells using lysosomotropic amines and carboxylic ionophores. Cancer Res, 50: 1243-50
29. Ryser HJ, Drummond I and Shen WC (1982) The cellular uptake of horseradish peroxidase and its poly(lysine) conjugate by cultured fibroblasts is qualitatively similar despite a 400-fold difference in rate. J Cell Physiol, 113: 167-178
30. Salacinski PR, Mclean C, Sykes JE, Clement-Jones VV and Lowry PJ (1981) Iodination of proteins, glycoproteins, and peptides using a solid-phase oxidizing agent, 1,3,4,6-tetrachloro-3 alpha, 6 alpha-diphenyl glycoluril (Iodogen). Anal Biochem, 117: 136-146
31. Smith A, Alberto R, Blaeuenstein P, Novak-Hofer I, Maecke HR and Schubiger PA (1993) Preclinical evaluation of 67Cu-labeled intact and fragmented anti-colon carcinoma monoclonal antibody MAb35. Cancer Res, 53: 5727-5733
32. Smith A, Alberto R and Shubiger PA (1994) Influence of radiolabel on the in vivo processing of intact and fragmented anti-tumour monoclonal antibody. J Nucl Biol Med 38: 54-58
33. Thedrez P, Sacca Vini JC, Nolibe D, Simoen JP, Guerreau D, Gestin JF, Kremer M and Chatal JF (1989) Biodistribution of indium-111-labeled OC 125 monoclonal antibody after intraperitoneal injection in nude mice intraperitoneally grafted with ovarian carcinoma. Cancer Res, 49: 3081-3086
34. Tochner Z, Mitchell JB, Smith P, Harrington F, Glatstein E, Russo D and Russo A (1986) Photodynamic therapy of ascites tumours within the peritoneal cavity. Br J Cancer 53: 733-736
35. Triguero D, Buciak JL and Pardridge WM (1991) Cationization of immunoglobulin G results in enhanced organ uptake of the protein after intravenous administration in rats and primate. J Pharmacol Exp Ther 258: 186-192
36. Veenhuizen RB, Ruevekamp-Helmers MC, Helmerhorst TJ, Kenemans P, Mooi WJ, Marijnissen JP and Stewart FA (1994) Intraperitoneal photodynamic therapy in the rat: comparison of toxicity profiles for photofrin and MTHPC. Int J Cancer 59: 830-836
37. Weagle G, Paterson PE, Kennedy J and Pottier R (1988) The nature of the chromophore responsible for naturally occurring fluorescence in mouse skin. J Photochem Photobiol B 2: 313-320
38. Yarmush ML, Thorpe WP, Strong L, Rakestraw SL, Toner M and Tompkins RG (1993) Antibody targeted photolysis. Crit Rev Ther Drug Carrier Syst 10: 197-252