Hibiscus Acid as an Inhibitor of Starch Digestion in the Caco-2 Cell Model System

Bioscience, Biotechnology and Biochemistry

Volumn 65, Issue 9, 2001, Pages 2087-2089

  Hansawasdi, Chanida ^a   Kawabata, Jun ^a   Kasai, Takanori ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Caco 2; Hibiscus acid; Hibiscus sabdariffa; Roselle tea; Starch digestion inhibitor

Indexed keywords

HIBISCUS; HIBISCUS SABDARIFFA;

ALPHA GLUCOSIDASE; AMYLASE; CITRIC ACID; GLUCOSE; HYDROXYCITRIC ACID; STARCH;

ANIMAL; ARTICLE; CELL STRAIN CACO 2; DIGESTION; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HUMAN; IC 50; METABOLISM; PANCREAS; SWINE;

ALPHA-AMYLASE; ALPHA-GLUCOSIDASES; ANIMALS; CACO-2 CELLS; CITRATES; CITRIC ACID; DIGESTION; GLUCOSE; HUMANS; INHIBITORY CONCENTRATION 50; PANCREAS; STARCH; SWINE;

EID: 0035464463     PISSN: 09168451     EISSN: None     Source Type: Journal    
DOI: 10.1271/bbb.65.2087     Document Type: Article

References (20)

1. Puls, W., Keup, U., Krause, H. P., Thomas, G., and Hoffmeister, F., Glucosidase inhibition: A new approach to the treatment of diabetes, obesity, and hyperlipoproteinaemia. Naturwissenschaften, 64, 536-537 (1977).
2. Watanabe, J., Kawabata, J., Kurihara, H., and Niki, R., Isolation and identification of α-glucosidase inhibitors from Tochu-cha (Eucommia ulmoides). Biosci. Biotechnol. Biochem., 61, 177-178 (1997).
3. Matsui, T., Yoshimoto, C., Osajima, K., Oki, T., and Osajima, Y., In vitro survey of α-glucosidase inhibitory food components. Biosci. Biotechnol. Biochem., 60, 2019-2022 (1996).
4. Nishioka, T., Watanabe, J., Kawabata, J., and Niki, R., Isolation and activity of N-p-coumaroyltyramine, an α-glucosidase inhibitor in welsh onion (Allium fistutosum). Biosci. Biotechnol. Biochem., 61, 1138-1141 (1997).
5. Jenkins, D. J. A., Taylor, R. H., Goff, D. V., Fielden, H., Misiewicz, J. J., Sarson, D. L., Bloom, S. R., and Alberti, K. G. M. M., Scope and specificity of acarbose in slowing carbohydrate absorption in man. Diabetes, 30, 951-954 (1981).
6. Hirsh, A. J., Yao, S. Y. M., Young, J. D., and Cheeseman, C. I., Inhibition of glucose absorption in the rat jejunum: A novel action of α-D-glucosidase inhibitors. Gastroenterology, 113, 205-211 (1997).
7. Breitmeier, D., Günther, S., and Heymann, H., Acarbose and 1-deoxynojirimycin inhibit maltose and maltooligosaccharide hydrolysis of human small intestinal glucoamylase-maltase in two different substrate-induced modes. Arch. Biochem. Biophys., 346, 7-14 (1997).
8. Hansawasdi, C., Kawabata, J., and Kasai, T., α-Amylase inhibitors from roselle (Hibiscus sabdariffa Linn.) tea. Biosci. Biotechnol. Biochem., 64, 1041-1043 (2000).
9. Pinto, M., Robine, R. S., Appay, M. D., Kedinger, M., Triadou, N., Dussaulx, E., Lacroix, B., Simon, P., Haffen, K., Fogh, J., and Zweibaum, A., Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture. Biol. Cell., 47, 323-330 (1983).
10. Chantret, I., Barbat, A., Dussaulx, E., Brattain, M. G., and Zweibaum, A., Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: A survey of twenty cell lines. Cancer Res., 48, 1936-1942 (1988).
11. Hilger, A. R., Conradi, R. A., and Burton, P. S., Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa. Pharmaceut. Res., 7, 902-910 (1990).
12. Boulenc, X., Marti, E., Joyeux, H., Roques, C., Berger, Y., and Fabre, G., Importance of the paracellular pathway for the transport of a new bisphosphonate using the human Caco-2 monolayers model. Biochem. Pharmacol., 46, 1591-1600 (1993).
13. Cogburn, J. N., Donovan, M. G., and Schasteen, C. S., A model of human small intestinal absorptive cells. 1. Transport Barrier. Pharmaceut. Res., 8, 210-216 (1991).
14. Nishioka, T., Kawabata, J., and Aoyama, Y., Baicalein, an α-glucosidase inhibitor from Scutellaria baicalensis. J. Nat. Prod., 61, 1413-1415 (1998).
15. Toda, M., Kawabata, J., and Kasai, T., α-Glucosidase inhibitors from Clove (Syzgium aromaticum). Biosci. Biotechnol. Biochem., 64, 294-298 (2000).
16. Hidalgo, I. J., Raub, T. J., and Borchardt, R. T., Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology, 96, 736-749 (1989).
17. Jenkins, D. J. A., Taylor, R. H., Goff, D. V., Fielden, H., Misiewicz, J. J., Sarson, D. L., Bloom, S. R., and Alberti, K. G. M. M., Scope and specificity of acarbose in slowing carbohydrate absorption in man. Diabetes, 30, 951-954 (1981).
18. Bischoff, H., Pharmacology of α-glucosidase inhibition. Eur. J. Clin. Invest., 24, 3-10 (1994).
19. Breitmeier, D., Gunther, S., and Heymann, H., Acarbose and 1-deoxynojirimycin inhibit maltose and maltooligosaccharide hydrolysis of human small intestinal glucoamylase-maltase in two different substrate-induced modes. Arch. Biochem. Biophys., 346, 7-14 (1997).
20. Hansawasdi, C., Kawabata, J., and Kasai, T., unpublished result.