Sex-dependent dietary obesity, induction of UCPs, and leptin expression in rat adipose tissues

Obesity Research

Volumn 9, Issue 9, 2001, Pages 579-588

  Rodríguez, Ana M ^a   Quevedo Coli, Santiago ^a   Roca, Pilar ^a   Palou, Andreu ^a  

^a UNIVERSITAT DE LES ILLES BALEARS   (Spain)

Author keywords

Postcafeteria fed; Sex associated differences; Thermogenesis; 2 adrenergic receptor; 3 adrenergic receptor

Indexed keywords

CAFETERIA; RATTUS NORVEGICUS;

ALPHA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; CARRIER PROTEIN; ION CHANNEL; LEPTIN; MEMBRANE PROTEIN; MESSENGER RNA; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN;

ADIPOSE TISSUE; ANIMAL; ARTICLE; BROWN ADIPOSE TISSUE; DIET; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; OBESITY; RAT; SEX DIFFERENCE; THERMOGENESIS; THERMOREGULATION; WISTAR RAT;

ADIPOSE TISSUE; ADIPOSE TISSUE, BROWN; ANIMALS; BODY TEMPERATURE REGULATION; CARRIER PROTEINS; DIET; FEMALE; GENE EXPRESSION REGULATION; ION CHANNELS; LEPTIN; MALE; MEMBRANE PROTEINS; MITOCHONDRIAL PROTEINS; OBESITY; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, ADRENERGIC, BETA-3; RNA, MESSENGER; SEX FACTORS; THERMOGENESIS;

EID: 0035459640     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2001.75     Document Type: Article

References (54)

1. Palou A, Picó C, Bonet ML, Oliver P. The uncoupling protein, thermogenin. Int J Biochem Cell Biol. 1998;30:7-11.
2. Ricquier D, Bouillaud F. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Biochem J. 2000;345:161-79.
3. Boss O, Samec S, Paoloni-Giacobino A, et al. Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Lett. 1997;408:39-42.
4. Fleury C, Neverova M, Collins S, et al. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet. 1997;15:269-72.
5. Gimeno RE, Dembski M, Weng X, et al. Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. Diabetes. 1997; 46:900-6.
6. Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB. UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem Biophys Res Commun. 1997;235:79-82.
7. Arsenijevic D, Onuma H, Pecqueur C, et al. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet. 2000;26:435-9.
8. Bouillaud F, Couplan E, Pecqueur C, Ricquier D. Homologues of the uncoupling protein from brown adipose tissue (UCP1): UCP2, UCP3, BMCP1 and UCP4. Biochim Biophys Acta. 2001;1504:107-19.
9. Gong DW, Monemdjou S, Gavrilova O, et al. Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3. J Biol Chem. 2000;275: 16251-7.
10. Vidal-Puig AJ, Grujic D, Zhang CY, et al. Energy metabolism in uncoupling protein 3 gene knockout mice. J Biol Chem. 2000;275:16258-66.
11. Clapham JC, Arch JR, Chapman H, et al. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean. Nature. 2000;406:415-8.
12. Roca P, Rodriguez AM, Oliver P, et al. Brown adipose tissue response to cafeteria diet-feeding involves induction of the UCP2 gene and is impaired in female rats as compared to males. Pflugers Arch. 1999;438:628-34.
13. Oliver P, Picó C, Palou A. Differential expression of uncoupling protein 1, 2 and 3 genes during rat development in 3 brown and white adipose tissue depots. Cell Mol Life Sci. 2001;58:470-6.
14. Puigserver P, Lladó I, Palou A, Gianotti M. Evidence for masking of brown adipose tissue mitochondrial GDP-binding sites in response to fasting in rats made obese by dietary manipulation: effects of reversion to standard diet. Biochem J. 1991;279:575-9.
15. Matamala JC, Gianotti M, Pericàs J, et al. Changes induced by fasting and dietetic obesity in thermogenic parameters of rat brown adipose tissue mitochondrial subpopulations. Biochem J. 1996;319:529-34.
16. Bronnikov G, Houstek J, Nedergaard J. β-adrenergic, cAMP-mediated stimulation of proliferation of brown fat cells in primary culture: mediation via β1 but not via β3 adrenoceptors. J Biol Chem. 1992;267:2006-13.
17. Cannon B, Nedergaard J. Adrenergic regulation of brown adipocyte differentiation. Biochem Soc Trans. 1996;24: 407-12.
18. Lindquist JM, Rehnmark S. Ambient temperature regulation of apoptosis in brown adipose tissue: erk1/2 promotes norepinephrine-dependent cell survival. J Biol Chem. 1998; 273:30147-56.
19. Giacobino JP. β3-adrenoceptor: an update. Eur J Endocrinol. 1995;132:377-85.
20. Puigserver P, Pico C, Stock MJ, Palou A. Effect of selective β-adrenoceptor stimulation on UCP synthesis in primary cultures of brown adipocytes. Mol Cell Endocrinol. 1996;117:7-16.
21. Lafontan M, Barbe P, Galitzky J, et al. Adrenergic regulation of adipocyte metabolism. Hum Reprod. 1997;12(suppl 1): 6-20.
22. Chaudhry A, Granneman JG. Differential regulation of functional responses by β-adrenergic receptor subtypes in brown adipocytes. Am J Physiol. 1999;277:R147-R53.
23. Valet P, Grujic D, Wade J, et al. Expression of human α2-adrenergic receptors in adipose tissue of β3-adrenergic receptor deficient mice promotes diet-induced obesity. J Biol Chem. 2000;275:34797-802.
24. Palou A, Serra F, Bonet ML, Picó C. Obesity: molecular bases of a multifactorial problem. Eur J Nutr. 2000;39: 127-44.
25. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 1998;395:763-70.
26. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425-32.
27. Giacobino JP. Role of the β3-adrenoceptor in the control of leptin expression. Horm Metab Res. 1996;28:633-7.
28. Quevedo S, Roca P, Picó C, Palou A. Sex-associated differences in cold-induced UCP1 synthesis in rodent brown adipose tissue. Pflugers Arch. 1998;436:689-95.
29. Lladó I, Proenza AM, Serra F, Palou A, Pons A. Dietary induced permanent changes in brown and white adipose tissue composition in rats. Int J Obes Relat Metab Disord. 1991;15: 415-9.
30. Lladó I, Estrany ME, Rodríguez E, Amengual B, Roca P, Palou A. Effects of cafeteria diet feeding on β3-adrenoceptor expression and lipolytic activity in white adipose tissue of male and female rats. Int J Obes Relat Metab Disord. 2000; 24:1-9.
31. Picó C, Pons A, Gianotti M, Palou A. Sustained changes in blood alpha amino nitrogen compartmentation during recovery from cafeteria feeding in rats. Arch Int Physiol Biochim Biophys. 1991;99:345-8.
32. Serra F, Bonet L, Palou A. Amino-acid-enzyme activities in brown and white adipose tissues and in the liver of cafeteria rats: effects of 24 hours starving. Arch Int Physiol Biochim. 1987;95:263-8.
33. Lladó I, Picó C, Palou A, Pons A. Protein and amino acid intake in cafeteria fed obese rats. Physiol Behav. 1995;58: 513-9.
34. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-54.
35. Nedergaard J, Cannon B. [3H]GDP binding and thermogenin amount in brown adipose tissue mitochondria from cold-exposed rats. Am J Physiol. 1985;248:C365-C71.
36. Wharton DC, Tzagoloff A. Cytochrome oxidase from beef heart mitochondria. In: Colowick SP, Kaplan NO, eds. Methods in Enzymology. Orlando, FL: Academic Press; 1967, pp. 245-50.
37. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227: 680-5.
38. Cervantes-Olivier P, Durieu-Trautmann O, Delavier-Klutchko C, Strosberg AD. The oligosaccharide moiety of the β1-adrenergic receptor from turkey erythrocytes has a biantennary, N-acetyllactosamine-containing structure. Biochemistry. 1985;24:3765-70.
39. Jacobsson A, Stadler U, Glotzer MA, Kozak LP. Mitochondrial uncoupling protein from mouse brown fat: molecular cloning, genetic mapping, and mRNA expression. J Biol Chem. 1985;260:16250-4.
40. Xu X, De Pergola G, Björntorp P. The effects of androgens on the regulation of lipolysis in adipose precursor cells. Endocrinology. 1990;126:1229-34.
41. Xu XF, De Pergola G, Björntorp P. Testosterone increases lipolysis and the number of β-adrenoceptors in male rat adipocytes. Endocrinology. 1991;128:379-82.
42. Xu X, De Pergola G, Eriksson PS, et al. Postreceptor events involved in the up-regulation of β-adrenergic receptor mediated lipolysis by testosterone in rat white adipocytes. Endocrinology. 1993;132:1651-7.
43. De Pergola G, Holmang A, Svedberg J, Giorgino R, Björntorp P. Testosterone treatment of ovariectomized rats: effects on lipolysis regulation in adipocytes. Acta Endocrinol (Copenh). 1990;123:61-6.
44. Giudicelli Y, Dieudonne MN, Lacasa D, Pasquier YN, Pecquery R. Modulation by sex hormones of the membranous transducing system regulating fatty acid mobilization in adipose tissue. Prostaglandins Leukot Essent Fatty Acids. 1993; 48:91-100.
45. Lafontan M, Berlan M. Fat cell adrenergic receptors and the control of white and brown fat cell function. J Lipid Res. 1993;34:1057-91.
46. Mauriege P, Prud'homme D, Lemieux S, Tremblay A, Després JP. Regional differences in adipose tissue lipolysis from lean and obese women: existence of postreceptor alterations. Am J Physiol. 1995;269:E341-E50.
47. Berman DM, Nicklas BJ, Rogus EM, Dennis KE, Goldberg AP. Regional differences in adrenoceptor binding and fat cell lipolysis in obese, postmenopausal women. Metabolism. 1998;47:467-73.
48. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 1998;92: 829-39.
49. Sears IB, MacGinnitie MA, Kovacs LG, Graves RA. Differentiation-dependent expression of the brown adipocyte uncoupling protein gene: regulation by peroxisome proliferator-activated receptor-γ. Mol Cell Biol. 1996;16: 3410-9.
50. Tcherepanova I, Puigserver P, Norris JD, Spiegelman BM, McDonnell DP. Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1. J Biol Chem. 2000;275:16302-8.
51. Oliver P, Picó C, Palou A. Ontogenesis of leptin expression in different adipose tissue depots in the rat. Pflugers Arch. 2001;442:383-90.
52. Zheng D, Jones JP, Usala SJ, Dohm GL. Differential expression of ob mRNA in rat adipose tissues in response to insulin. Biochem Biophys Res Commun. 1996;218:434-7.
53. Machinal F, Dieudonne MN, Leneveu MC, Pecquery R, Giudicelli Y. In vivo and in vitro ob gene expression and leptin secretion in rat adipocytes: evidence for a regional specific regulation by sex steroid hormones. Endocrinology. 1999;140:1567-74.
54. Nonogaki K. Obesity: autonomic circuits versus feeding. Nat Med. 1999;5:742-3.