Glutamine potentiates TNF-α-induced tumor cytotoxicity

Free Radical Biology and Medicine

Volumn 31, Issue 5, 2001, Pages 642-650

  Obrador, Elena ^a   Carretero, Julian ^a   Esteve, Juan M ^a   Pellicer, José A ^a   Pascual, Antonio ^a   Petschen, Ignacio ^b   Estrela, José M ^a,c  

^a UNIVERSITY OF VALENCIA   (Spain)

^b HOSPITAL UNIVERSITARIO LA FE   (Spain)

^c UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Apoptosis; Cancer growth; Free radicals; Glutamine; Glutathione; Mitochondria; Necrosis; Oxidative stress; TNF

Indexed keywords

BUTHIONINE SULFOXIMINE; CYTOCHROME C; FREE RADICAL; GLUTAMINE; GLUTATHIONE; NITROGEN; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DEATH; CELL LEVEL; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; EHRLICH ASCITES TUMOR; ELEMENTAL DIET; ENZYME DEFICIENCY; ENZYME INHIBITION; ENZYME SYNTHESIS; GENE EXPRESSION; MALE; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NECROSIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TUMOR CELL CULTURE;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELL DIVISION; CELL SURVIVAL; CYTOCHROME C GROUP; DIET; DRUG SYNERGISM; FREE RADICALS; GLUTAMINE; GLUTATHIONE; HYDROGEN PEROXIDE; MALE; MEMBRANE POTENTIALS; MICE; MITOCHONDRIA; NECROSIS; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXYGEN; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SUPEROXIDES; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035451231     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00622-0     Document Type: Article

References (53)

1. The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells
2. Glutamine and cancer
3. Mitochondrial glutathione depletion by glutamine in growing tumor cells
4. Mitochondrion as a novel target of anticancer chemotherapy
5. Mitochondrial control of cell death
6. High affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function
7. Redox regulation of apoptosis: Impact of thiol oxidation status on mitochondrial function
8. The role of glutathione in the regulation of apoptosis
9. Regulation of glutathione metabolism in Ehrlich ascites tumor cells
10. Protein metabolism in the tumor-bearing mouse. Rates of protein synthesis in host tissues and in an Ehrlich ascites tumor at different stages in tumor growth
11. Glutathione and the rate of cellular proliferation determine tumor cell sensitivity to tumor necrosis factor in vivo
12. Mitochondrial damage in muscle occurs after marked depletion of glutathione and is prevented by giving glutathione mono ester
13. Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples
14. A high-performance liquid chromatography method for measurement of oxidized glutathione in biological samples
15. Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL
16. Bioenergetic consequences of accumulating the common 4977-bp mitochondrial DNA deletions
17. Changes in mitochondrial membrane potential during staurosporine-induced apoptosis in Jurkat cells
18. Altered mitochondrial functions in fibroblasts containing MELAS or MERRF mitochondrial DNA mutations
19. 2 production by macrophages and neutrophiles with homovanillic acid and horse-radish peroxidase
20. Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2′,7′-dichlorofluorescin
21. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein dye binding
22. Quantitation of bcl-2 protein in bladder cancer tissue by enzyme immunoassay: Comparison with western blot and immunochemistry
23. Inhibition of target cell mitochondrial electron transfer by tumour necrosis factor
24. Tumor necrosis factor-alpha induces superoxide anion generation in mitochondria of L929 cells
25. Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity
26. Recombinant human tumor necrosis factor-α: Effects on proliferation of normal and transformed cells
27. Signal transduction by tumor necrosis factor
28. A death-domain-containing receptor that mediates apoptosis
29. Selective species specificity of tumor necrosis factor for toxicity in the mouse
30. Glutathione defiency produced by inhibition of its synthesis, and its reversal: Applications in research and therapy
31. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic proteolytic cascade
32. Redox regulation of the caspases during apoptosis
33. Thioltransferase (glutaredoxin) is detected within HIV-1 and can regulate the activity of glutathionylated HIV-1 protease in vitro
34. Inhibition of cancer growth and selective glutathione depletion in Ehrlich ascites tumor cells in vivo by extracellular ATP
35. Glutathione mnoethyl ester; preparation, uptake by tissues, and conversion to glutathione
36. Resistance to radiation-induced apoptosis in Bcl-2 expressing cells by depleting cellular thiols
37. The proto-oncogene Bcl-2 and its role in regulating apoptosis
38. Expression of BCL-2 protein enhances the survival of mouse fibrosarcoid cells in tumor necrosis factor-mediated cytotoxicity
39. Bcl-2 expression causes redistribution of glutathione to the nucleus
40. DNA damage induced by tumor necrosis factor-alpha in L929 cells is mediated by mitochondrial oxygen radical formation
41. Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation
42. Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites
43. The mitochondrial death/life regulator in apoptosis and necrosis
44. The thiol crosslinking agent diamide overcomes the apoptosis-inhibitory effect of Bcl-2 by enforcing mitochondrial permeability transition
45. Bcl-2 inhibition of neural death: Decreased generation of reactive oxygen species
46. Rescue of cells from apoptosis by inhibition of active GSH extrusion
47. Mitochondrial phospholipid hydroperoxide glutathione peroxidase plays a major role in preventing oxidative injury to cells
48. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione
49. Activation of the OxyR transcription factor by reversible disulfide bond formation
50. Redox regulation of transcriptional activators
51. Hormones, glutathione status and protein S-thiolation
52. Elimination of Ehrlich tumours by ATP-induced growth inhibition, glutathione depletion and X-rays