Testicular toxicity in F344 rats by aminophenylnorharman, formed from norharman and aniline

Toxicology and Applied Pharmacology

Volumn 175, Issue 2, 2001, Pages 169-175

  Totsuka, Yukari ^a   Kawamori, Toshihiko ^a   Hisada, Shigeru ^b   Mitsumori, Kunitoshi ^c   Ishihara, Junko ^a   Sugimura, Takashi ^a   Wakabayashi, Keiji ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b Grelan Pharmaceutical Co Ltd   (Japan)

^c TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

Aminophenylnorharman; Aniline; F344 rat; Heterocyclic amine; Norharman; Sertoli cell; Testicular toxicity

Indexed keywords

AMINOPHENYLNORHARMAN; ANILINE; BETA CARBOLINE; BETA CARBOLINE DERIVATIVE; INDOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLADDER DISEASE; MALE; NONHUMAN; RAT; REPRODUCTIVE TOXICITY; SEMINIFEROUS TUBULE; SERTOLI CELL; SPERMATOGENESIS; TESTIS DISEASE; THYMUS ATROPHY;

ANIMALIA;

EID: 0035449766     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2001.9236     Document Type: Article

References (24)

1. Identification and quantitative determination of aniline and toluidines in human urine
2. A comparison of the effects on the three isomers of dinitrobenzene on the testis in the rat
3. The morphogenesis of testicular degeneration induced in rats by orally administered 2,5-hexanedione
4. The effects of feed restriction on reproductive function in Sprague-Dawley rats
5. Detection of monocyclic aromatic amines, possible mammary carcinogenesis, in human milk
6. Heterocyclic aromatic amine formation in grilled bacon, beef and fish and in grill scrapings
7. Acute effects and long-term sequelae of 1,3-dinitrobenzene on male reproduction in the rat. II. Quantitative and qualitative histopathology of the testis
8. Aniline and aniline hydrochloride
9. Sertoli cell toxicants
10. Primary aromatic amines from side-stream cigarette smoke are common contaminants of indoor air
11. A novel quantitative morphometry of germ cells for the histopathological evaluation of rat testicular toxicity
12. Formation of DNA adducts by the co-mutagen norharman with aromatic amines
13. Demonstration of mutagenicity of aniline and o-toluidine by norharman
14. Differences in effects of norharman with various classes of chemical mutagens and amounts of S-9
15. The isolation of harmane and norharmane from tobacco and cigarette smoke
16. Biomonitoring of urinary aromatic amines and arylamine hemoglobin adducts in exposed workers and nonexposed control persons
17. Short-term morphological response of the rat testis to administration of five chemotherapeutic agents
18. Reproductive tract lesions resulting from subchronic administration (63 days) of tri-o-cresyl phosphate in male rats
19. Mutagenic principle(s) in tryptophan and phenylalanine pyrolysis products
20. Metabolic aspects of the comutagenic action of norharman
21. Structural determination of a mutagenic aminophenylnorharman produced by the co-mutagen norharman with aniline
22. Quantification of the co-mutagenic β-carbolines, norharman and harman, in cigarette smoke condensates and cooked foods
23. Norharman and harman in human urine
24. Food-derived mutagens and carcinogens