Inhibition of the neutrophil NADPH oxidase and associated H+ channel by diethyl pyrocarbonate (DEPC), a histidine-modifying agent: Evidence for at least two target sites

Biochemical Journal

Volumn 358, Issue 2, 2001, Pages 315-324

  Mankelow, T J ^a   Henderson, L M ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Proton channel; Superoxide; Therapeutic

Indexed keywords

ENZYME INHIBITION; PROTEINS; PROTONS; REDUCTION;

TARGET SITES;

BIOCHEMISTRY;

CYTOCHROME B; DIETHYL PYROCARBONATE; GLYCOPROTEIN; GLYCOPROTEIN GP 91; HISTIDINE; HYDROGEN; IODONITROTETRAZOLIUM VIOLET; PROTEIN P47; PROTEIN P67; PROTON; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL MEMBRANE; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME MECHANISM; GENE TRANSLOCATION; HUMAN; HUMAN CELL; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN BINDING; PROTON TRANSPORT; REDUCTION;

CYTOCHROME B GROUP; DIETHYL PYROCARBONATE; HEME; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; INDICATORS AND REAGENTS; ION CHANNELS; ION TRANSPORT; NADPH OXIDASE; NEUTROPHILS; OXIDATION-REDUCTION; PROTONS; SUBCELLULAR FRACTIONS; SUPEROXIDES; TETRAZOLIUM SALTS;

EID: 0035448083     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3580315     Document Type: Article

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