Influence of the replacement of the oxo function with the thioxo group on the antimycobacterial activity of 3-aryl-6,8-dichloro-2H-1,3-benzoxazine-2,4(3H)-diones and 3-arylquinazoline-2,4(1H,3H)-diones

Farmaco

Volumn 56, Issue 10, 2001, Pages 803-807

  Waisser, Karel ^a   Gregor, Jiří ^a   Dostál, Hynek ^a   Kuneš, Jioí ^a   Kubicová, Lenka ^a   Klimešová, Věra ^a   Kaustová, Jarmila ^b  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b Regional Institute of Hygiene   (Czech Republic)

Author keywords

Antimycobacterial activity; Benzoxazines; Mycobacteria; Quinazolines; Tubeculostatics

Indexed keywords

3 (3 CHLOROPHENYL) 6,8 DICHLORO 2H 1,3 BENZOXAZINE 2,4(3H) DITHIONE; 3 (3,4 DICHLOROPHENYL)QUINAZOLINE 2,4(1H,3H) DITHIONE; 3 (4 BROMOPHENYL) 6,8 DICHLORO 2H 1,3 BENZOXAZINE 2,4(3H) DITHIONE; 3 (4 BROMOPHENYL)QUINAZOLINE 2,4(1H,3H) DITHIONE; 3 (4 CHLOROPHENYL) 6,8 DICHLORO 2H 1,3 BENZOXAZINE 2,4(3H) DITHIONE; 3 (4 CHLOROPHENYL)QUINAZOLINE 2,4(1H,3H) DITHIONE; 3 (4 METHYLPHENYL) 6,8 DICHLORO 2H 1,3 BENZOXAZINE 2,4(3H) DITHIONE; 3 (4 METHYLPHENYL)QUINAZOLINE 2,4(1H,3H) DITHIONE; 3 PHENYL 6,8 DICHLORO 2H 1,3 BENZOXAZINE 2,4(3H) DITHIONE; 3 PHENYLQUINAZOLINE 2,4(1H,3H) DITHIONE; 6,8 DICHLORO 2H 1,3 BENZOXAZINE 2,4(3H) DIONE DERIVATIVE; OXYGEN; QUINAZOLINE 2,4(1H,3H) DIONE DERIVATIVE; QUINAZOLINE 2,4(1H,3H) DITHIONE DERIVATIVE; SULFUR; T 2299; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; MYCOBACTERIUM AVIUM; MYCOBACTERIUM KANSASII; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN;

ANTITUBERCULAR AGENTS; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM; OXAZINES; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035445139     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(01)01134-X     Document Type: Article

References (10)

1. Synthesis of 2-benzylthiopyridine-4-carbothioamide derivatives and their antimycobacterial, antifungal and photosynthesis-inhibiting activity
2. New pyridine derivatives as potential antimicrobial agents
3. Relationships between the chemical structure of antimycobacterial substances and their activity against atypical strains. Part 14: 3-Aryl-6,8-dihalogeno-2H-1,3-benzoxazine-2,4(3H)-diones
4. Relationships between the chemical structure of substances and their antimycobacterial activity against atypical strains. Part 18. 3-Phenyl-2,4-benzoxazine-2,4(3H)-diones and isosteric 3-phenylquinazoline-2,4(1H,3H)-diones
5. Quinazoline derivatives with antitubercular activity
6. Quinoxaline derivatives as potential antitubercular agents
7. Synthesis of N,N′-diarylalkyldiamines and their antimycobacterial and antialgal activity
8. Some antimycobacterial thiolactams
9. New groups of antimycobacterial agents: 6-chloro-3-phenyl-4-thioxo-2H-1,3-benzoxazine-2(3H)-ones and 6-chloro-3-phenyl-2H-1,3-benzoxazine-2,4(3H)-dithiones
10. Syntheses von 2,4-Dithioxo-1,2,3,4-tetrahydrochinazolinen